question stringlengths 11 194 | answer stringlengths 1 934 | context_chunks sequence | document_id int64 187 2.68k | id int64 239 5.32k |
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What is the main cause of HIV-1 infection in children? | Mother-to-child transmission (MTCT) is the main cause of HIV-1 infection in children worldwide. | [
"BACKGROUND: Mother-to-child transmission MTCT is the main cause of HIV-1 infection in children worldwide. Given that the C-type lectin receptor, dendritic cell-specific ICAM-grabbing non-integrin-related DC-SIGNR, also known as CD209L or liver/lymph node–specific ICAM-grabbing non-integrin L-SIGN , can interact wi... | 630 | 262 |
What plays the crucial role in the Mother to Child Transmission of HIV-1 and what increases the risk | DC-SIGNR plays a crucial role in MTCT of HIV-1 and that impaired placental DC-SIGNR expression increases risk of transmission. | [
"BACKGROUND: Mother-to-child transmission MTCT is the main cause of HIV-1 infection in children worldwide. Given that the C-type lectin receptor, dendritic cell-specific ICAM-grabbing non-integrin-related DC-SIGNR, also known as CD209L or liver/lymph node–specific ICAM-grabbing non-integrin L-SIGN , can interact wi... | 630 | 276 |
How many children were infected by HIV-1 in 2008-2009, worldwide? | more than 400,000 children were infected worldwide, mostly through MTCT and 90% of them lived in sub-Saharan Africa. | [
"BACKGROUND: Mother-to-child transmission MTCT is the main cause of HIV-1 infection in children worldwide. Given that the C-type lectin receptor, dendritic cell-specific ICAM-grabbing non-integrin-related DC-SIGNR, also known as CD209L or liver/lymph node–specific ICAM-grabbing non-integrin L-SIGN , can interact wi... | 630 | 278 |
What is the role of C-C Motif Chemokine Ligand 3 Like 1 (CCL3L1) in mother to child transmission of HIV-1? | High copy numbers of CCL3L1, a potent HIV-1 suppressive ligand for CCR5, are associated with higher chemokine production and lower risk of MTCT of HIV-1 among South African infants | [
"BACKGROUND: Mother-to-child transmission MTCT is the main cause of HIV-1 infection in children worldwide. Given that the C-type lectin receptor, dendritic cell-specific ICAM-grabbing non-integrin-related DC-SIGNR, also known as CD209L or liver/lymph node–specific ICAM-grabbing non-integrin L-SIGN , can interact wi... | 630 | 316 |
What is DC-GENR and where is it expressed? | "Dendritic cell-specific ICAM-grabbing non-integrin-related (DC-SIGNR, also known as CD209L or liver(...TRUNCATED) | ["BACKGROUND: Mother-to-child transmission MTCT is the main cause of HIV-1 infection in children wor(...TRUNCATED) | 630 | 305 |
How does the presence of DC-SIGNR affect the MTCT of HIV-1? | "the presence of DC-SIGNR at the placental endothelial cell surface may protect infants from HIV-1 i(...TRUNCATED) | ["BACKGROUND: Mother-to-child transmission MTCT is the main cause of HIV-1 infection in children wor(...TRUNCATED) | 630 | 306 |
Why do low levels of DC-SIGNR enhance Mother to Child Transmission of HIV-1? | "in placenta containing low levels of DC-SIGNR, HIV-1 would preferentially binds CCR5 on endothelial(...TRUNCATED) | ["BACKGROUND: Mother-to-child transmission MTCT is the main cause of HIV-1 infection in children wor(...TRUNCATED) | 630 | 307 |
What is the percentage of Mother to Child Transmission of HIV-1, when there is no intervention? | "Without specific interventions, the rate of HIV-1 mother-tochild transmission (MTCT) is approximate(...TRUNCATED) | ["BACKGROUND: Mother-to-child transmission MTCT is the main cause of HIV-1 infection in children wor(...TRUNCATED) | 630 | 277 |
Does C-C chemokine receptor type 5 (CCR5) affect the transmission of HIV-1? | "Genetic variants in CCR5 have been shown to influence vertical transmission of HIV-1. CCR5 promoter(...TRUNCATED) | ["BACKGROUND: Mother-to-child transmission MTCT is the main cause of HIV-1 infection in children wor(...TRUNCATED) | 630 | 312 |
How does Mannanose Binding Lectin (MBL) affect elimination of HIV-1 pathogen? | "Mannose-binding lectin (MBL) is an innate immune receptor synthesised in the liver and secreted in (...TRUNCATED) | ["BACKGROUND: Mother-to-child transmission MTCT is the main cause of HIV-1 infection in children wor(...TRUNCATED) | 630 | 318 |
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