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00073369cfbb2c967215
Therapeutic use of vancomycin is characterized by decreased susceptibilities and increasing reports of clinical failures. Few studies have examined the clinical outcomes of patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia treated with vancomycin. The primary objective was to compare clinical...
000863a953c6943997f2
To investigate whether there is an association between HLA class II and distal interphalangeal osteoarthritis (DIP OA). The study group consisted of consecutive patients with and without DIP OA aged between 40 and 70 years. DIP OA was diagnosed by radiology. These patients were referred to an "Early Arthritis Clinic" (...
0009327ec147709dc736
Tumor necrosis factor (TNF) signaling protects against ischemia/reperfusion-induced cardiomyocyte death, in vitro, ex vivo, and in vivo. TNF-receptor-associated factor 2 (TRAF2), an E3 ubiquitin ligase, coordinates cytoprotective signaling downstream of both TNF receptors, via unclear mechanisms. Noting that TRAF2 is r...
0009f1fe32c8bf00d126
We sought to evaluate the long-term impact of post-cardiac surgery atrial fibrillation on the risk of stroke and survival. Patients undergoing isolated CABG surgery from April 1, 1995 to March 31, 2007 were identified (n = 8058). Long-term stroke data were compiled using Cox modeling adjusted for clinical characteristi...
000c3ba4a12dd5f86d12
Cost effective next generation sequencing technologies now enable the production of genomic datasets for many novel planktonic eukaryotes, representing an understudied reservoir of genetic diversity. O. tauri is the smallest free-living photosynthetic eukaryote known to date, a coccoid green alga that was first isolate...
000cbff6b4b201222d65
The purpose of this study was to determine if endogenous heparin release would modulate the hemostatic response to hemorrhagic shock in rabbits. Anesthetized rabbits (n = 13) underwent hemorrhagic shock (MAP 30-40 mm Hg) for 60 minutes. Blood samples obtained before and 60 minutes after hemorrhagic shock had thrombelas...
000df7dedaca7038e037
Commensal bacteria can activate signaling by the Toll-like and interleukin-1 receptors (TLR and IL-1R) to mediate pathogenesis of inflammatory bowel diseases and colitis-associated cancer. We investigated the role of the single immunoglobulin IL-1 receptor-related (SIGIRR) molecule, a negative regulator of TLR and IL-1...
000e2f25bdcc4c432a2f
Pitt-Hopkins syndrome is characterized by severe mental retardation, characteristic dysmorphic features, and susceptibility to childhood-onset seizures and intermittent episodes of hyperventilation. This syndrome is caused by haploinsufficiency of TCF4, which encodes a basic helix-loop-helix transcription factor. Misse...
00108297baa464a17489
Myocardial ischemia plays a central role in the development of right ventricular failure after acute pulmonary embolism. This study investigates whether pulmonary mediators act specifically on coronary tone and cardiac contractile function in acute pulmonary microembolization and whether such effects are altered in the...
0010ca6d4096b98abdea
The challenge of resident education in urologic surgery programs is to overcome disparity imparted by diverse patient populations, limited training times, and inequalities in the availability of expert surgical educators. Specifically, in the area of prosthetic urology, only a small proportion of programs have full-tim...
00116cb84818dbf689ba
There has been no definitive randomized study to identify the optimal therapeutic regimen for treating squamous cell carcinoma of tonsil. The purpose of this study was to retrospectively evaluate the treatment outcome according to various combinations of surgery, radiation therapy and chemotherapy. Fifty-six patients w...
0011d200e2608e8293fd
There is a high prevalence of low testosterone and dyslipidaemia in men with type 2 diabetes. The androgen receptor CAG repeat polymorphism (AR CAG) affects receptor transcriptional activity (the shorter repeats the more sensitive AR) and is associated with androgenic parameters and obesity. This study describes the re...
0012d32439087a18fc15
Measurements of both arterial compliance and endothelium-dependent vasodilation have previously been related to coronary risk factors, but not in the same study. In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, we studied the interplay between arterial compliance and endothelium-dep...
0012e73efad2d01d4a14
Diabetes induces great alterations in female reproductive function. We analyzed the effects of tungstate, an anti-diabetic agent, on the reproductive function of healthy and diabetic female rats. Healthy and streptozotocin-induced diabetic rats were treated with sodium tungstate (2 mg/ml in their drinking water) for 12...
00140ef19402bfb18bf1
Childhood sexual abuse (CSA) has been associated with alterations in brain morphology using region of interest analyses that have focused on stress-sensitive target regions. This study was designed to ascertain the effects on gray matter volume (GMV) of exposure to CSA in healthy young adult college students selected b...
00172410f337b9ee666f
Metabolic syndrome (Met.S) consists of a conglomeration of obesity, hypertension, glucose intolerance, and dislipidemia. Frontal-subcortical geriatric syndrome (FSCS) is caused by ischemic disruption of the frontal-subcortical network. It is unknown if Met.S is associated with FSCS. We evaluated 422 community-dwelling ...
0017a38a4695d0cd2260
Little information exists about successful brace treatment of progressive early onset scoliosis. Even less information is available about the early treatment of scoliosis patients with Marfan's syndrome at age < 6 years. Purpose of this case report is to demonstrate the possibility of successful brace treatment in a pa...
001804b6883425a1411f
In patients with acute liver failure loss of cerebral blood flow autoregulation may result from cerebral vasodilatation. Since arterial hypocapnia induces cerebral vasoconstriction, we investigated whether cerebral blood flow autoregulation could be reestablished by mechanical hyperventilation. Seven consecutive patien...
0018cd547d7462b51559
Despite the advances made in immunosuppression therapy, episodes of acute cellular rejection may affect graft function and survival. We investigated the role of RANTES in cellular recruitment and in cardiac allograft rejection. Endomyocardial biopsies (n = 65) from 30 patients were taken at various times after transpla...
001ae616d1c66346d6d7
c-Met is a receptor tyrosine kinase involved in cell growth, invasion, metastases, and angiogenesis. In this study, we investigated the role of c-Met in melanoma biology using a novel small-molecule tyrosine kinase inhibitor SU11274 and small interfering (si) RNA against the receptor. The effects of SU11274 and c-Met s...
001f3bcf8bdd1c45d314
A functionally intact endothelial monolayer is thought to be critical for the adaptive process of vascular remodeling. This study was undertaken to examine the hypothesis that endothelial restoration is a critical determinant of remodeling after balloon angioplasty. Rabbits (N=12) were fed a cholesterol-supplemented di...
001f95f06f043f39d94e
The genetic variants of xenobiotic-metabolizing enzymes, such as those encoded by glutathione-S-transferase (GST) genes, may be associated with the risk of coronary artery disease (CAD). To investigate the genetic factors for CAD, we examined the GSTM1, GSTT1, GSTP1, and GSTA1 genotypes in a CAD cohort in Taiwan. Our s...
0020d8a0c73368d4d621
Traumatic brain injury (TBI) initiates a neuroinflammatory response that increases the risk of TBI-related mortality. Acute alcohol intoxication at the time of TBI is associated with improved survival. Ethanol is recognized as a systemic immunomodulator that may also impart neuroprotection. The effects of alcohol on TB...
00214f340b46e9c56665
Cardiac ischemia-reperfusion (I-R) injury represents a major cause of cardiac tissue injury. Adenosine signaling dampens inflammation during cardiac I-R. The authors investigated the role of the adenosine A2b-receptor (Adora2b) on inflammatory cells during cardiac I-R. To study Adora2b signaling on inflammatory cells, ...
0022e2b2cc4d12889286
Gingival cells respond to periodontal pathogens by generating reactive oxygen species, and such a condition would increase circulating oxidative stress. Improvement of gingival inflammation by toothbrushing may offer clinical benefits on not only periodontal health but also the circulatory conditions. We examined the e...
0022f6dee4ec5c42539f
The immediate assistance of a cytologist during EUS-guided FNA is not universal. The optimal number of fine needle passes during EUS-guided FNA has not been determined in a prospective study. The aim of this study was to determine the optimal number of passes required to obtain a correct diagnosis. Seven or more passes...
0024f107cdc8478cfa16
After shallow bolus inhalation of radiolabeled aerosols, gamma camera imaging has shown a left-right asymmetry, with a higher fraction of deposited particles in the left lung. It was not clear, however, whether this phenomenon was an effect of asymmetry in lung ventilation or aerosol deposition efficiency. Lung ventila...
00259192cdb208705adf
There is a recent trend toward performing most hand surgery procedures under local and/or regional anesthesia without sedation. However, little evidence exists regarding the postoperative complications associated with local/regional anesthesia without sedation, especially compared with local/regional anesthesia with se...
0026bb9815a9b52fd671
Metastatic breast cancer cells frequently and ectopically express the transcription factor RUNX2, which normally attenuates proliferation and promotes maturation of osteoblasts. RUNX2 expression is inversely regulated with respect to cell growth in osteoblasts and deregulated in osteosarcoma cells. Here, we addressed w...
002938d7938fcec2ceef
Chromosome 9p21 single nucleotide polymorphisms (SNPs) have been shown to be associated with coronary heart disease in multiple studies. The aim of the present study was to identify whether these SNPs are associated with recurrent myocardial infarction (MI), revascularization, or death in acute coronary syndrome (ACS) ...
0029b84a5111b10d9392
Epidermal growth factor (EGF) inhibits bombesin-induced activation of phosphoinositide-specific phospholipase C (PLC) in pancreatic acini. The aim of this study was to investigate the mechanism by which EGF inhibits bombesin-induced activation of PLC. Intact pancreatic acini were pretreated with pertussis toxin to stud...
002a79ab6d05df9d29fc
The purpose of this study was to examine the relationship between gestational age and outcomes of outborn versus inborn preterm infants. Multivariable logistic regression analysis was used to examine gestational age-specific, risk-adjusted outcomes of 2962 singleton infants who were born at <32 weeks of gestation who w...
002cf77616a991074fcd
Rift Valley fever (RVF) is a severe mosquito-borne disease affecting humans and domestic ruminants. Mosquito saliva contains compounds that counteract the hemostatic, inflammatory, and immune responses of the host. Modulation of these defensive responses may facilitate virus infection. Indeed, Aedes mosquito saliva pla...
002d794aa6fc26cb5a91
Lymphotoxin alpha (LTα) is expressed in human atherosclerotic lesions and genetic variations in the LTα pathway have been linked to myocardial infarction. Activation of the P2Y2 nucleotide receptor (P2Y2R) regulates the production of LTα. in vitro. We aimed to uncover a potential pathway linking purinergic receptor to ...
002de07620f976f7b7b1
Seroma formation, a common complication of abdominoplasty, can cause patient discomfort and inconvenience. This study aimed to compare seroma rates after ligation and diathermy of large abdominal perforating vessels during abdominoplasty. Consecutive patients undergoing abdominoplasty with epigastric undermining betwee...
002ffaa2b92300eda071
Most lung transplant (LTx) recipients recover sufficient functional status to resume working, yet unemployment is common after LTx. Weak local labor markets may limit employment opportunities for LTx recipients. United Network for Organ Sharing data on first-time LTx recipients 18-60 years old who underwent transplant ...
003061a1a44be3234b9d
The authors determined whether the trophic effects of bombesin (BBS) on the small bowel mucosa are mediated by either nonluminal factors or endogenous luminal secretion. The gut hormone bombesin stimulates growth of small bowel mucosa. The mechanisms responsible for this trophic effect are not known. Rats underwent con...
0030b3675fecd2d5c64a
To examine whether age-related increase in concentrations of circulating inflammatory mediators is due to concurrent increases in cardiovascular risk factors or is independent of these. Cytokines (IL-6, IL-18), chemokines (6Ckine, MCP-1, IP-10), soluble adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) and adipokines ...
00341269ff4bdf8465f2
We studied the effect of pregnancy on atazanavir pharmacokinetics in the presence and absence of tenofovir. This was a non-randomized, open-label, multicentre Phase IV study in HIV-infected pregnant women recruited from European HIV treatment centres. HIV-infected pregnant women treated with boosted atazanavir (300/100...
0034996c5771873062ef
Systemic adiponectin is reduced in patients with cardiovascular disease (CVD) and low adiponectin may contribute to the pathogenesis of atherosclerosis. However, circulating adiponectin is elevated in type 1 diabetes (T1D) patients, who have also a higher incidence to develop CVD. Because monocytes play an important ro...
0035688e81093469df61
To evaluate mechanisms involved in mevastatin-induced inhibition of proliferation of ovarian theca-interstitial cells. In vitro study. Academic laboratory. Immature Sprague-Dawley female rats. Ovarian theca-interstitial cells were cultured without and with mevastatin in the presence and absence of serum, mevalonic acid...
0038116f22e4c1aaaa05
We compared patient opinions concerning reservoir/bladder function as well as quality of life (QOL) after cystectomy for bladder carcinoma and continent cutaneous urinary diversion or orthotopic bladder reconstruction. Fifteen patients with Kock reservoirs (11 females, 4 males) and 11 men with orthotopic bladders answe...
00390ca87f7bc20e27a6
Apple polyphenols could represent a novel nutritional approach in the management and control of blood glucose, especially in type 2 diabetics. The aim of this study was to test the therapeutic potential of an apple polyphenol extract (APE) in an insulin-resistant rat model and to determine the molecular basis of insuli...
003a47abfb22f39bceca
Asthma and rhinitis often co-exist and there are data to suggest that they may be two ends of the same disease spectrum. Immunohistochemical studies have shown that eosinophilia in the airways is a feature of rhinitic patients without asthma. The aim of our study was to examine whether cellular infiltration exists in t...
003c825ec98f808fb231
Several noninvasive measures of cardiac risk such as heart rate variability (HRV) cannot be used in patients with atrial fibrillation (AF). One promising exception is the measure of ventricular cycle length entropy (VCLE) where initial data suggest that a reduction in VCLE portends an increased risk of cardiac death in...
003cfd40f80dfa4247b4
It is unclear whether plastic or metal stents are more suitable for preoperative biliary decompression in pancreatic cancer. The objective of this study was to compare the rate of endoscopic reinterventions in patients with pancreatic cancer undergoing plastic or self-expandable metal stent (SEMS) placements for preope...
003dda93f64cabb21d28
Hypoxic cell death follows interruption of blood supply to tissues. Although successful restoration of blood flow is mandatory for salvage of ischemic tissues, reperfusion can paradoxically place tissues at risk of further injury. Brief periods of ischemia applied at the onset of reperfusion have been shown to reduce i...
003e859a6cbc9b100f9b
We investigated whether color-coded Doppler sonography combined with an ultrasound contrast medium would improve the assessment of liver-supplying vessels after orthotopic liver transplantation. Forty-seven patients after orthotopic liver transplantation participated. Examinations were done without and then with the ul...
00404ddda08c68f095a0
In mice, melanoma inhibitory activity (MIA) is a chondrocyte-specific molecule with similar regulation to collagen type II. As MIA is a small secreted protein, its value as cartilage biomarker in human inflammatory arthritis was assessed. MIA tissue distribution was studied by quantitative PCR and immunohistochemistry....
0040ed78705e63e7c0c9
to investigate the effects cannabidiol (CBD) on delayed-type hypersensitivity (DTH) reactions and antigen-induced T-cell cytokine expression. DTH was induced by subcutaneous ovalbumin (OVA) challenge to the footpads of mice sensitized with OVA. Inflammatory reactions were measured by footpad swelling and histological a...
004307f3f26d44fdfcb8
To determine whether captopril (CAP) therapy had an effect on the minute ventilation/carbon dioxide output (VE/VCO2) ratio at submaximal levels of exercise in asymptomatic patients with reduced left ventricular function after myocardial infarction. Double blinded, randomized, prospective, repeated measures. One hundred...
00440f361ba053b24a61
To evaluate the association between metastasis-inducing protein S100A4 and disease activity in patients with RA, and to demonstrate the effect of TNF-alpha blocking therapy on plasma levels of S100A4 in these patients. Plasma levels of the S100A4 protein were analysed in 40 anti-TNF-alpha naive patients with active RA....
00451e0fce44dfec0e35
Obesity has an important impact on the future of total joint arthroplasty; however, the definition and influence of obesity on surgical risks and outcomes remain controversial. Our hypothesis was that percent body fat was better than body mass index (BMI) at identifying clinical risks and patient-reported functional ou...
004655dbaa3d7372fffc
D. melanogaster is an excellent animal model to study how the circadian (≅24-h) timing system and sleep regulate daily wake-sleep cycles. Splicing of a temperature-sensitive 3'-terminal intron (termed dmpi8) from the circadian clock gene period (per) regulates the distribution of daily activity in Drosophila. The role ...
004765e52c40bcde446f
Platinum drugs are the most powerful chemotherapeutic agents in the treatment of ovarian cancer. We demonstrated previously that unexpectedly ovarian cancer cells are sensitised to cisplatin (CDDP) by the hepatocyte growth factor (HGF), usually considered an anti-apoptotic factor. We used quantitative polymerase chain ...
00480a4f68e0e9fb7a7a
Regulation of N-methyl-d-aspartate (NMDA) subunits NR2A and NR2B expression during status epilepticus (SE) remains incompletely understood. Here we explored the role of brain-enriched microRNA (miR)-139-5p in this process. miRNA microarray was performed to examine changes in miRNA expression in the rat pilocarpine mode...
0048191cf48d80e4b780
Although it has been postulated that liver injury results in impaired clearance of bacteria from the blood, no prior study has evaluated hepatic bacterial clearance during sepsis. We hypothesized that liver injury during the evolution of sepsis would result in impaired hepatic bacterial clearance. Mild and severe bacte...
00482c74c7bcc34a7e24
Progesterone is essential for the proliferation and differentiation of mammary gland epithelium. Studies of breast cancer cells have demonstrated a biphasic progesterone response consisting of an initial proliferative burst followed by sustained growth arrest. However, the transcriptional factors acting with the proges...
00497b01e226c1183b10
Interest in the biology of endogenous progenitor cells (EPCs) continues to grow as evidence of their role in vascular repair mounts. EPC enumeration requires specialized laboratory techniques and is performed immediately after sample acquisition, limiting the clinical contexts in which EPC enumeration can be performed ...
0049cd7f8dbb4bc39b55
Thrombosis occurs at sites of vascular injury when platelets adhere to subendothelial matrix proteins and to each other. Platelets express many surface receptor proteins, the function of several of these remains poorly characterized. Cadherin 6 is expressed on the platelet surface and contains an arginine-glycine-aspar...
004b0dc5579883fbf5a9
To investigate the level of interleukin-6 in advanced non-small cell lung cancer and to analyze the relationship with malnutrition and survival. Seventy-one newly diagnosed advanced non-small cell lung cancer patients were enrolled in this prospective study. Malnutrition was defined by using subjective global assessmen...
004c5d6916b15fc80b70
Modified digestive reconstruction during pancreaticoduodenectomy (PD) may affect the postoperative incidence of delayed gastric emptying (DGE). The purpose of this study is to investigate whether Braun enteroenterostomy following PD can reduce the incidence of DGE. Four hundred seven patients who received PD with child...
004dc465ef0a920f6a69
Evidence suggests that glutamatergic systems may be involved in the pathophysiology of major depression and the mechanism of action of antidepressants. We have investigated the effects of amitriptyline, a tricyclic antidepressant, on the activity of the excitatory amino acid transporter type 3 (EAAT3), a protein that c...
004f3dd8263c9d8c8985
The objective of this study was to determine whether down-regulation of pyruvate dehydrogenase phosphatase (PDP) is responsible for poorly active pyruvate dehydrogenase (PDH) in circulating lymphocytes (CLs) of obese subjects (ObS), and if so, whether it improves when their plasma insulin rises. PDH activity was compar...
0055bc57987b4a06bf7e
This study evaluated mothers with diabetes to determine whether prepregnancy body mass index (BMI), BMI on delivery or gestational weight gain (GWG) had the greatest impact on maternal and neonatal outcomes. We retrospectively examined the medical charts of 634 full-term infants born to mothers with gestational diabete...
005755ee7064157f575d
Resveratrol (RV), a naturally occurring phytoalexin, exerts manifold biological effects against a variety of human tumor cell lines. In this study, the cytotoxic and biological effects of novel RV derivatives were investigated in prostate cancer cells. Cytotoxicity of the compounds was assessed by clonogenic assays in ...
00578645017428226586
FOXC1 mutations result in Axenfeld-Rieger syndrome, a disorder characterized by a broad spectrum of malformations of the anterior segment of the eye and an elevated risk for glaucoma. A novel FOXC1 W152G mutation was identified in a patient with aniridia. Molecular analysis was conducted to determine the functional con...
005791994e1f16bca58e
Human milk provides a multitude of glycoproteins, including highly glycosylated α-1-acid glycoprotein (AGP), which elicits anti-inflammatory and immunomodulatory properties. The milk AGP glycoforms may provide the breastfed infant with a wide range of biological benefits. Here, we analyzed the reactivity of O-linked su...
005a0e10482ab8f7dbf5
Three-dimensional (3D) computer graphics are increasingly used to supplement the teaching of anatomy. While most systems consist of a program which produces 3D renderings on a workstation with a standard screen, the Dextrobeam virtual reality VR environment allows the presentation of spatial neuroanatomical models to l...
005b168092e2457c2ec0
Temporary, ablation-mediated effects such as oedema may cause reversible pulmonary vein (PV) isolation. To investigate this, point-by-point circumferential ablation was performed to achieve acute electrical PV isolation with an incomplete circumferential ablation line. Then, the impact of this intentional 'visual gap' ...
005b9445d230624a7957
Antipsychotic drugs have been shown to modulate the expression of ATP-binding cassette transporter A1 (ABCA1), a key factor in the anti-atherogenic reverse cholesterol transport process, in vitro. Here we evaluated the potential of the typical antipsychotic drug haloperidol to modulate the cholesterol efflux function o...
005f22e60b8f64b80d24
Coronary calcification detected by electron beam tomography may improve cardiovascular risk prediction. The technique is particularly promising in the elderly because the predictive power of cardiovascular risk factors weakens with age. We investigated the prognostic value of coronary calcification for cardiovascular e...
0060158ca8530f196f7c
Patterns of concerted fluctuation in populations-synchrony-can reveal impacts of climatic variability on disease dynamics. We examined whether malaria transmission has been synchronous in an area with a common rainfall regime and sensitive to the Indian Ocean Dipole (IOD), a global climatic phenomenon affecting weather...
006120334e613fd4457e
This study aimed to investigate whether different types of memory stimulus provide different information during the Wada or intracarotid amytal procedure (IAP) in patients with refractory medial temporal lobe epilepsy (MTLE). Eighty nine surgical candidates with documented MTLE and selected for left hemispheric languag...
0061f1cad49033af0913
The impact of high physician workload and job stress on quality and outcomes of healthcare delivery is not clear. Our study explored whether high workload and job stress were associated with lower performance in general practices in the Netherlands. Secondary analysis of data from 239 general practices, collected in pr...
0063fc48b29748ad2aee
We have previously hypothesized that obsessive-compulsive (OC) tendencies are associated with a general lack of subjective conviction regarding internal states, which leads to compensatory seeking of and reliance on more discernible substitutes (proxies) for these states (Lazarov, A., Dar, R., Oded, Y., & Liberman, N. ...
006456a596a52fd99590
To test the effectiveness of combining conventional antineoplastic drugs (cisplatin and etoposide) with metformin in the treatment of non-small cell lung cancer in the NCI-H460 cell line, in order to develop new therapeutic options with high efficacy and low toxicity. We used the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphen...
00648d226483f13bc440
Hypoxic-ischemic injury (HI) to preterm brain results in white matter loss. The endogenous oligodendroglial response to perinatal HI is characterized by increased oligodendroglial progenitor cells (OPCs). MicroRNAs (miRs) are important post-transcriptional regulators of gene expression, and a few miRs have been shown t...
0064f60a6d7e15b777a3
To identify novel variants associated with anthracycline-induced cardiotoxicity and to assess these in a genotype-guided risk prediction model. Two cohorts treated for childhood cancer (n = 344 and 218, respectively) were genotyped for 4578 SNPs in drug ADME and toxicity genes. Significant associations were identified ...
00679d293d57365e6627
To investigate the relationship between relapse and the levels of the residual amount of HBV DNA in serum at cessation in chronic hepatitis B patients meeting 2008 Asian Pacific Association for the Study of the Liver (APASL) nucleos(t)ide analogs (NAs) cessation criteria. A total of 72 chronic hepatitis B patients who ...
00680222afec0de2de87
The regulation of endometrial physiology and morphogenesis by the paracrine effectors has been well established using in vivo studies. A more complete understanding of the endometrial function has been delayed due, in part, to a lack of appropriate culture models. In this study, we aimed to simulate the in vivo three-d...
00688455975035dff6df
The aim of the study was to explore the potential role of myeloid differentiation factor 88 (MyD88), which acts as an adaptor in the TLR4 signalling pathway, in immune responses of the pancreatic duct during acute pancreatitis. Primary cultures of pancreatic duct epithelial cells from Wistar rats and cultures of the pa...
006aad7a2d41e17c9696
The aim of the study is to determine whether a biodegradable elastomeric device that uses an osmotic pressure delivery mechanism can release different therapeutic proteins at a nearly constant rate in nanomolar concentrations with high bioactivity, given the same formulation conditions. Vascular endothelial growth fact...
006d758645b27f905006
Brevetoxin (PbTx), taken from the earlier species name Ptychodiscus brevis, is a red algae toxin. It has been associated with clinically observed bronchoconstriction in nonasthmatics. In asthmatics, similar exposures may produce severe transient effects, sometimes requiring emergency treatment, thus suggesting that ast...
006f391e7c7d055b08c1
MicroRNAs (miRNA) are a class of small noncoding RNA molecules that have been implicated in a wide variety of basic cellular functions through posttranscriptional regulations on their target genes. Compelling evidence has shown that miRNAs are involved in cancer initiation and progression. We hypothesized that genetic ...
0072e7f8107a5e985ba9
Angiotensin II type 1 (AT1) receptor overexpression may play a decisive role in endothelial dysfunction during oestrogen deficiency in spontaneously hypertensive rats (SHRs). Similarly, exaggerated production of angiotensin II and enhanced expression of AT1 receptor have been reported in vessels of SHRs compared with n...
0072fe812c8d85df4838
Despite the number of albinism-causing mutations identified in human patients and animal models, there remain a significant number of cases for which no mutation has been identified, suggesting that our understanding of melanogenesis is incomplete. Previously, we identified two oculocutaneous albinism mutations in zebr...
0075ee69394c32bbea2b
The appendage domain of the gammaCOP subunit of the COPI vesicle coat bears a striking structural resemblance to adaptin-family appendages despite limited primary sequence homology. Both the gammaCOP appendage domain and an equivalent region on betaCOP contain the FxxxW motif; the conservation of this motif suggested t...
00776268c734d9a9a881
Cryptococcus neoformans (C. neoformans) is a globally distributed fungal pathogen with the potential to cause serious disease, particularly among immune compromised hosts. Exposure to this organism is believed to occur by inhalation and may result in pneumonia and/or disseminated infection of the brain as well as other...
007adb72bf912a995cdb
Vascular remodeling diseases (VRD) are mainly characterized by inflammation and a vascular smooth muscle cells (VSMCs) proproliferative and anti-apoptotic phenotype. Recently, the activation of the advanced glycation endproducts receptor (RAGE) has been shown to promote VSMC proliferation and resistance to apoptosis in...
007b0ce20136fdf1b3aa
The sodium-glucose transporter 2 (SGLT2) inhibitors Canagliflozin and Dapagliflozin are recently approved medications for type 2 diabetes. Recent studies indicate that SGLT2 inhibitors may inhibit the growth of some cancer cells but the mechanism(s) remain unclear. Cellular proliferation and clonogenic survival were us...
007cf225adb06770034a
Matrix metalloproteinases are involved in tumor invasion and metastatic spread. Expression of metalloproteinases is induced by the extracellular matrix metalloproteinase inducer (EMMPRIN). Their activity can be inhibited by several tissue inhibitors of metalloproteinases (TIMP1-to-4). Whereas TIMP-1 expression is descr...
007e267ae7217a2377a8
The effects of deep brain stimulation of the subthalamic nucleus (DBS-STN) and L-dopa (LD) on cortical activity in Parkinson's disease (PD) are poorly understood. By combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG) we explored the effects of STN-DBS, either alone or in combination with...
007e852fa7e6dcfd78c3
Minocycline, a broad-spectrum tetracycline antibiotic, has shown anti-inflammatory and neuroprotective effects in ischemic brain injury. The present study seeks to determine whether monocyte chemotactic protein-induced protein 1 (MCPIP1), a recently identified modulator of inflammatory reactions, is involved in the cer...
007e8ca045c648294b54
To test, in a canine model of right ventricular ischemia with 15 cm H2O positive end-expiratory pressure, whether collateral perfusion through overlapping vessels from the left ventricle to the right ventricular free wall can reduce infarct size. Randomized, prospective, controlled, experimental study in dogs. Anesthes...
007f04bf080656bdc539
Thoracoscopically assisted anterior spinal arthrodesis and instrumentation is being used more widely to treat idiopathic scoliosis. However, harvesting autologous bone increases operative time and morbidity. The purpose of this study was to compare autologous iliac crest and rib graft with recombinant human bone morpho...
007f3774a86b59e5960f
To determine the clinically recognizable error rate with the use of quantitative polymerase chain reaction (qPCR)-based comprehensive chromosomal screening (CCS). Retrospective study. Multiple fertility centers. All patients receiving euploid designated embryos. Trophectoderm biopsy for CCS. Evaluation of the pregnancy...
007f9adda06340938174
Nitric oxide (NO), produced by normal vascular endothelial cells, reduces platelet aggregation and thrombus formation. NO-releasing biopolymers have the potential to prolong vascular graft and stent patency without adverse systemic vasodilation. 5-mm polyurethane vascular grafts coated with a polymer containing the NO-...
00813b26d4ed86563c36
Blau syndrome is a rare, autosomal-dominant, autoinflammatory disorder characterized by granulomatous arthritis, uveitis, and dermatitis. Genetics studies have shown that the disease is caused by single nonsynonymous substitutions in NOD-2, a member of the NOD-like receptor or NACHT-leucine-rich repeat (NLR) family of ...
00840858364c8f09d73d
There have been many studies suggesting that localized scleroderma has a strong autoimmune background, although the lesions are usually limited to the skin and subcutaneous tissue. Here we summarize previous data on the autoimmunity of localized scleroderma, mostly published in the last two decades, because there has n...
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PubMedQA — Training, unified schema

A seeded sample of qiaojin/PubMedQA, config pqa_artificial, made into retrieval training pairs and reshaped into the strict schema shared by every dataset in this collection. One of the 15 domain sources (code, medical, science, finance, legal) added to the collection's general sources.

Source qiaojin/PubMedQA @ 9001f2853fb8, config pqa_artificial
Task biomedical question → abstract
Domain · languages medical · eng
Queries / documents / qrels 49,969 / 49,969 / 49,969
Qrels per query min 1 · mean 1.0 · max 1
Score values 2 ×49,969 (2: the first positive, 1: any other)
Layout queries · corpus · qrels · hard-negatives · teacher-scores, split train
Splits corpus: train · hard-negatives: train · judgments: train · qrels: train · queries: train · teacher-scores: train
Hard negatives sources: dense · 4,946,948 rows
Teacher scores jinaai/jina-reranker-v3.5 · 4,996,917 rows (positives included)
Judgments judgments: typesafe/jev-1.13.0 · 664,597 rows
Ids sha1(text)[:20]; identical texts collapse to one document / query
License mit

Schema

config columns rules
queries id: string, text: string ids unique and non-empty; every query has ≥ 1 qrel
corpus id: string, title: string, text: string title is always present ("" when the source has none)
qrels query-id: string, corpus-id: string, score: int32 referential integrity to both tables; no duplicate pairs; no floats
hard-negatives query-id: string, corpus-id: string, rank: int32, source: string one row per negative; (query-id, corpus-id, source) unique; never a labelled positive of the same query
teacher-scores query-id: string, corpus-id: string, teacher: string, score: float32 one row per scored pair (positives included); a row means scored — never a placeholder
judgments query-id: string, corpus-id: string, judge: string, role: string, p_yes: float64, round: int32 one row per judged pair; role is positive (the training positive) or candidate (a mined candidate, never a labelled positive or a labelled negative); p_yes in [0, 1]; round 0 the first request, 1.. the top-ups

Files are Parquet, sorted by id, zstd-compressed, sharded at 500 MB. Every rule above is checked before publishing; provenance.json records the source revision, what changed, and the output file hashes.

What changed from the source

  • sampled: a seeded random sample (seed 1) of up to 50,000 pairs
  • reshaped: the question is the query; the document is the abstract's context sentences (context.contexts) joined by spaces
  • decontaminated (exact): a pair was dropped when its normalised query equals any evaluation query, or a positive equals a document of a test or dev corpus; a repeated query keeps its first pair
  • decontaminated (near-duplicates): 31 passages that nearly copy an evaluation document some evaluation query judges relevant, and 0 queries that nearly copy an evaluation query (word 13-grams for passages, 8-grams for queries; at least half shared with one text of the 23 test sets (BEIR, RTEB, LitSearch) or the 6 dev sets) were removed, and with them 31 queries in total; near copies of evaluation-corpus documents that no evaluation query judges relevant were kept
  • text: leading and trailing whitespace stripped; otherwise as converted above
  • ids re-keyed to sha1(text)[:20]: 0 documents and 0 queries collapsed into identical texts
  • added a title column filled with "" (the source has none)

Hard negatives and teacher scores

Filled by the owner's annotation pipeline (annotation=jina35-u2) for the train split of the query set(s) below; queries without a labelled positive are left out.

  • Candidates: dense retrieval with jinaai/jina-embeddings-v5-text-small over the full corpus to depth 1,000; 100 candidates per query drawn from the rank windows 1–30 (30), 31–100 (30), 101–300 (20), 301–1000 (20), the query's labelled positives excluded. rank is the dense rank; source is dense for a mined row and dataset for a negative the source labels itself (those are kept for every query of the split, sampled or not).
  • Teacher: jinaai/jina-reranker-v3.5, listwise: a query's positive and all of its candidates are scored together in one context of up to 32,768 tokens. score is the raw cosine score, one row per (query, positive) and per (query, candidate); a labelled negative that was also mined is scored once. Every document was cut to its first 1,024 reranker tokens before scoring (max_doc_tokens=1024). No filtering is applied to the tables.
configs queries hard negatives teacher scores
hard-negatives · teacher-scores 49,969 (all) 4,946,948 (4,946,948 dense) 4,996,917
from datasets import load_dataset
negatives = load_dataset("Hyukkyu/train-pubmedqa", "hard-negatives", split="train")
scores    = load_dataset("Hyukkyu/train-pubmedqa", "teacher-scores", split="train")

Jev judgments

judgments holds, for every query of the training sample (the queries with teacher scores), whether TypeSafe's Jev (jev-1.13.0) judged its training positive and its mined candidates relevant: p_yes is Jev's P(yes) for the source's question (e.g. does the passage answer the query?). They locate the false negatives among the mined candidates and the mislabelled positives.

  • Requests. One request per query (round 0): its training positive, its candidates whose teacher score taken as (cos + 1) / 2 is at least 0.85 × the positive's (at most 12, the highest scores) and 4 random candidates below that, shuffled under neutral ids, one yes/no question per passage. Queries left with fewer than 10 candidates under their source's cutoff got their next hardest unjudged candidates in rounds 1–8 (8 per request), those still under 10 in rounds 9–10 (24 per request). The dataset's own labelled negatives were never sent. Texts were cut to 512 (query) and 512 (passage) tokens of the jina-embeddings-v5 small tokenizer. Jev answers a request's passages in one context, so P(yes) is calibrated to these groups: the thresholds below apply to this table, not to single-pair calls.
  • Accuracy (an audit of 1237 pairs from the pilot's first requests (100 queries per source; the five long-query sources re-piloted at 512-token queries), labelled blind by an LLM (Claude), at the pilot's fixed thresholds 0.35 and 0.15): a candidate at P(yes) ≥ 0.35 was relevant 67% of the time inside the band (n = 350) and 45% below it (n = 87); one under 0.35 was relevant 6% (band, n = 387) and 1% (below the band, n = 210) of the time. A positive under 0.15 was mislabelled 100% of the time (n = 20) in the sources that keep the check; in dom-casehold, dom-clerc, dom-cornstack-py, dom-finqa10k, dom-gerlayqa, dom-investopedia, dom-lawse, dom-magicoder, dom-medmcqa, dom-pubmedqa, dom-s2orc, dom-tatqa, Jev's flags were right less often (0%–57% in this audit), under the 70% the check needs, so their positives are not checked.
  • Use (the SPARSE loader, annotation.filter.judge): a candidate at P(yes) ≥ its source's cutoff (below; fitted on 1,521 labelled pairs) is never a negative; a positive under 0.15 is replaced by the candidate Jev scores highest if that is ≥ 0.8, else the query is dropped; a candidate at ≥ 0.9 can become an extra positive. Compare p_yes as a float64 (it is stored as one).
config queries rows candidates per query top-up rows candidate cutoff positive check
judgments 49,969 664,597 12.3 402,728 0.35 skipped

Load it

from datasets import load_dataset
queries   = load_dataset("Hyukkyu/train-pubmedqa", "queries", split="train")
corpus    = load_dataset("Hyukkyu/train-pubmedqa", "corpus", split="train")
qrels     = load_dataset("Hyukkyu/train-pubmedqa", "qrels", split="train")
negatives = load_dataset("Hyukkyu/train-pubmedqa", "hard-negatives", split="train")
scores    = load_dataset("Hyukkyu/train-pubmedqa", "teacher-scores", split="train")
judgments = load_dataset("Hyukkyu/train-pubmedqa", "judgments", split="train")

License and attribution

The data is redistributed under the source's terms — mit. All credit belongs to the original authors; see the source repository (https://huggingface.co/datasets/qiaojin/PubMedQA). This repository is an independent repackaging.

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