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# **ProtGPT2**
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ProtGPT2 ([peer-reviewed paper](https://www.nature.com/articles/s41467-022-32007-7)) is a language model that speaks the protein language and can be used for de novo protein design and engineering. ProtGPT2 generated sequences conserve natural proteins' critical features (amino acid propensities, secondary structural content, and globularity) while exploring unseen regions of the protein space.
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<div style="background-color:#fff3cd; border-left:6px solid #ffcc00; padding:12px; border-radius:6px;">
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**💥 IMPORTANT INFORMATION**
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We have released ProtGPT3! The models show much higher performance across tasks, so we strongly recommend updating your current protocols and starting to use our newer versions. See the related paper [here](https://www.biorxiv.org/content/10.64898/2026.06.04.730041v1), and download the models [here](https://huggingface.co/collections/AI4PD/protgpt3-family). Let us know if you have any questions!
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</div>
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# **ProtGPT2**
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ProtGPT2 ([peer-reviewed paper](https://www.nature.com/articles/s41467-022-32007-7)) is a language model that speaks the protein language and can be used for de novo protein design and engineering. ProtGPT2 generated sequences conserve natural proteins' critical features (amino acid propensities, secondary structural content, and globularity) while exploring unseen regions of the protein space.
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