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No woman treated with acyclovir had a cesarean for herpes , compared with nine of 25 ( 36 % ) of those treated with placebo ( OR 0.04 , CI 0.002-0 .745 ; P = .002 ) . | RESULTS | {"id": "8532270:6", "pmid": "8532270", "sentence_index": 6, "split_group_id": "8532270"} |
No patient in either treatment group experienced asymptomatic genital viral shedding at delivery . | RESULTS | {"id": "8532270:7", "pmid": "8532270", "sentence_index": 7, "split_group_id": "8532270"} |
No neonate had evidence of herpes infection or adverse effects from acyclovir . | RESULTS | {"id": "8532270:8", "pmid": "8532270", "sentence_index": 8, "split_group_id": "8532270"} |
Suppressive acyclovir therapy reduced the need for cesarean for recurrent herpes in women whose first clinical episode of genital HSV occurred during pregnancy . | CONCLUSIONS | {"id": "8532270:9", "pmid": "8532270", "sentence_index": 9, "split_group_id": "8532270"} |
Suppressive acyclovir treatment did not increase asymptomatic viral shedding and was not harmful to the term fetus . | CONCLUSIONS | {"id": "8532270:10", "pmid": "8532270", "sentence_index": 10, "split_group_id": "8532270"} |
To compare the tolerance , efficacy , and pharmacokinetics of amphotericin deoxycholate ( Fungizone ) prepared in a parenteral fat emulsion ( Intralipid 20 % ) or glucose in HIV patients with candidiasis . | OBJECTIVE | {"id": "1458072:0", "pmid": "1458072", "sentence_index": 0, "split_group_id": "1458072"} |
Non-blind randomised controlled trial . | METHODS | {"id": "1458072:1", "pmid": "1458072", "sentence_index": 1, "split_group_id": "1458072"} |
University hospital ; tertiary clinical care . | METHODS | {"id": "1458072:2", "pmid": "1458072", "sentence_index": 2, "split_group_id": "1458072"} |
22 HIV positive patients with oral candidiasis . | METHODS | {"id": "1458072:3", "pmid": "1458072", "sentence_index": 3, "split_group_id": "1458072"} |
Amphotericin 1 mg/kg/day given on four consecutive days as a one hour infusion dissolved in either 5 % glucose ( amphotericin-glucose ) or parenteral fat emulsion at a final concentration of 2 g/l fat emulsion ( amphotericin-fat emulsion ) . | METHODS | {"id": "1458072:4", "pmid": "1458072", "sentence_index": 4, "split_group_id": "1458072"} |
Clinical tolerance ( fever , chills , sweats , nausea , arterial pressure , and pulse rate ) ; biological tolerance ( serum creatinine , electrolyte , and magnesium values ) ; clinical score of candidiasis ; and serum concentrations of amphotericin . | METHODS | {"id": "1458072:5", "pmid": "1458072", "sentence_index": 5, "split_group_id": "1458072"} |
11 patients were enrolled in each group . | RESULTS | {"id": "1458072:6", "pmid": "1458072", "sentence_index": 6, "split_group_id": "1458072"} |
All the amphotericin-fat emulsion infusions were given without serious problem whereas four amphotericin-glucose infusions were stopped because of renal impairment ( n = 3 ) or severe chills ( n = 2 ) , or both . | RESULTS | {"id": "1458072:7", "pmid": "1458072", "sentence_index": 7, "split_group_id": "1458072"} |
For patients completing the amphotericin-glucose treatment creatine concentration increased by 42 mumol/l ; four of seven patients had at least one creatinine value > or = 133 mumol/l versus one of 11 receiving amphotericin-fat emulsion . | RESULTS | {"id": "1458072:8", "pmid": "1458072", "sentence_index": 8, "split_group_id": "1458072"} |
Magnesium concentration fell significantly with amphotericin-glucose but not with amphotericin-fat emulsion . | RESULTS | {"id": "1458072:9", "pmid": "1458072", "sentence_index": 9, "split_group_id": "1458072"} |
Clinical side effects were noted in 36/38 infusions with amphotericin-glucose but 10/44 with amphotericin-fat emulsion . | RESULTS | {"id": "1458072:10", "pmid": "1458072", "sentence_index": 10, "split_group_id": "1458072"} |
Oral candidiasis score was reduced similarly in both groups . | RESULTS | {"id": "1458072:11", "pmid": "1458072", "sentence_index": 11, "split_group_id": "1458072"} |
Serum amphotericin concentrations were significantly lower and the volume of distribution of the drug higher after infusion of amphotericin-fat emulsion than after amphotericin-glucose . | RESULTS | {"id": "1458072:12", "pmid": "1458072", "sentence_index": 12, "split_group_id": "1458072"} |
Clinical and renal toxicity of amphotericin are reduced when the drug is prepared in fat emulsion . | CONCLUSIONS | {"id": "1458072:13", "pmid": "1458072", "sentence_index": 13, "split_group_id": "1458072"} |
Preparation is simple and cost effective . | CONCLUSIONS | {"id": "1458072:14", "pmid": "1458072", "sentence_index": 14, "split_group_id": "1458072"} |
Its efficacy is similar to that of conventional amphotericin . | CONCLUSIONS | {"id": "1458072:15", "pmid": "1458072", "sentence_index": 15, "split_group_id": "1458072"} |
Rate control of atrial fibrillation ( AF ) has become a main treatment modality , but we need more knowledge regarding the different drugs used for this purpose . | OBJECTIVE | {"id": "24135831:0", "pmid": "24135831", "sentence_index": 0, "split_group_id": "24135831"} |
In this study , we aimed to compare the effect of four common rate-reducing drugs on exercise capacity and levels of N-terminal pro-B-type natriuretic peptide ( NT-proBNP ) in patients with permanent AF . | OBJECTIVE | {"id": "24135831:1", "pmid": "24135831", "sentence_index": 1, "split_group_id": "24135831"} |
We included 60 patients ( mean age 71 9 years , 18 women ) with permanent AF and normal left ventricular function in a randomized , cross-over , investigator-blind study . | RESULTS | {"id": "24135831:2", "pmid": "24135831", "sentence_index": 2, "split_group_id": "24135831"} |
Diltiazem 360 mg , verapamil 240 mg , metoprolol 100 mg , and carvedilol 25 mg were administered o.d. for 3 weeks . | RESULTS | {"id": "24135831:3", "pmid": "24135831", "sentence_index": 3, "split_group_id": "24135831"} |
At baseline and on the last day of each treatment period , the patients underwent a maximal cardiopulmonary exercise test and blood samples were obtained at rest and at peak exercise . | RESULTS | {"id": "24135831:4", "pmid": "24135831", "sentence_index": 4, "split_group_id": "24135831"} |
The exercise capacity ( peak VO2 ) was significantly lower during treatment with metoprolol and carvedilol compared with baseline ( no treatment ) or treatment with diltiazem and verapamil ( P < 0.001 for all ) . | RESULTS | {"id": "24135831:5", "pmid": "24135831", "sentence_index": 5, "split_group_id": "24135831"} |
Compared with baseline , treatment with diltiazem and verapamil significantly reduced the NT-proBNP levels both at rest and at peak exercise , whereas treatment with metoprolol and carvedilol increased the levels ( P < 0.05 for all ) . | RESULTS | {"id": "24135831:6", "pmid": "24135831", "sentence_index": 6, "split_group_id": "24135831"} |
Rate-reducing treatment with diltiazem or verapamil preserved exercise capacity and reduced levels of NT-proBNP compared with baseline , whereas treatment with metoprolol or carvedilol reduced the exercise capacity and increased levels of NT-proBNP . | CONCLUSIONS | {"id": "24135831:7", "pmid": "24135831", "sentence_index": 7, "split_group_id": "24135831"} |
Post-exposure prophylaxis for rabies with cell culture vaccines by the conventional intramuscular regimen is very expensive . | BACKGROUND | {"id": "11467142:0", "pmid": "11467142", "sentence_index": 0, "split_group_id": "11467142"} |
The World Health Organization has advocated two cost-effective intradermal regimens with cell culture vaccines for use in developing countries . | BACKGROUND | {"id": "11467142:1", "pmid": "11467142", "sentence_index": 1, "split_group_id": "11467142"} |
We evaluated these two regimens -- the 2-site and the 8-site regimens -- in terms of immunogenicity , safety and tolerance in people with category I exposure to rabies . | BACKGROUND | {"id": "11467142:2", "pmid": "11467142", "sentence_index": 2, "split_group_id": "11467142"} |
Eighty-two subjects who had mild category I exposure to rabies were immunized using a purified chick embryo cell vaccine . | METHODS | {"id": "11467142:3", "pmid": "11467142", "sentence_index": 3, "split_group_id": "11467142"} |
The first regimen given to 43 subjects , consisted of intradermal administration of 0.2 ml of vaccine at 2 sites on days 0 , 3 and 7 and at one site on days 28 and 90 . | METHODS | {"id": "11467142:4", "pmid": "11467142", "sentence_index": 4, "split_group_id": "11467142"} |
The second regimen , given to 39 subjects , consisted of intradermal administration of 0.1 ml of vaccine at 8 sites on day 0 , at 4 sites on day 7 and at one site on days 28 and 90 . | METHODS | {"id": "11467142:5", "pmid": "11467142", "sentence_index": 5, "split_group_id": "11467142"} |
The mouse neutralization test was used to estimate titres of rabies neutralizing antibody in these subjects on different days after vaccination . | METHODS | {"id": "11467142:6", "pmid": "11467142", "sentence_index": 6, "split_group_id": "11467142"} |
The subjects were followed up for 1 year . | METHODS | {"id": "11467142:7", "pmid": "11467142", "sentence_index": 7, "split_group_id": "11467142"} |
Both regimens produced adequate neutralizing antibody titres from day 14 onwards , though the second regimen produced a more rapid antibody response and significantly higher titres ( p < 0.001 ) on all days tested . | RESULTS | {"id": "11467142:8", "pmid": "11467142", "sentence_index": 8, "split_group_id": "11467142"} |
There were minimal side-effects and both regimens were well tolerated . | RESULTS | {"id": "11467142:9", "pmid": "11467142", "sentence_index": 9, "split_group_id": "11467142"} |
Both the 2-site and 8-site intradermal regimens with purified chick embryo cell vaccine produce adequate levels of neutralizing antibodies but the 8-site regimen appears to be more immunogenic . | CONCLUSIONS | {"id": "11467142:10", "pmid": "11467142", "sentence_index": 10, "split_group_id": "11467142"} |
The feasibility of using these cost-effective regimens in routine practice needs to be further evaluated under the field conditions prevalent in India . | CONCLUSIONS | {"id": "11467142:11", "pmid": "11467142", "sentence_index": 11, "split_group_id": "11467142"} |
Discrete-choice experiments are based on the premise that any good or service can be described by its characteristics ( or attributes ) , and the extent to which an individual values a good or service depends on the levels of these characteristics . | BACKGROUND | {"id": "21766893:0", "pmid": "21766893", "sentence_index": 0, "split_group_id": "21766893"} |
Little is known about patient preferences for treatment of chronic musculoskeletal pain such as Achilles tendinopathy . | BACKGROUND | {"id": "21766893:1", "pmid": "21766893", "sentence_index": 1, "split_group_id": "21766893"} |
A discrete-choice experiment was conducted in 58 adults with a history of Achilles tendon pain at the conclusion of a three-arm randomized clinical trial . | METHODS | {"id": "21766893:2", "pmid": "21766893", "sentence_index": 2, "split_group_id": "21766893"} |
Participants were asked to complete a questionnaire consisting of ten hypothetical treatment scenarios and some sociodemographic questions . | METHODS | {"id": "21766893:3", "pmid": "21766893", "sentence_index": 3, "split_group_id": "21766893"} |
For each scenario , participants were asked to choose which option they would prefer if seeking treatment for their painful Achilles tendon . | METHODS | {"id": "21766893:4", "pmid": "21766893", "sentence_index": 4, "split_group_id": "21766893"} |
A mixed logit model was estimated to quantify subject preferences and marginal willingness to pay for the treatment attributes . | METHODS | {"id": "21766893:5", "pmid": "21766893", "sentence_index": 5, "split_group_id": "21766893"} |
A response rate of 62 % was achieved . | RESULTS | {"id": "21766893:6", "pmid": "21766893", "sentence_index": 6, "split_group_id": "21766893"} |
A significant positive impact on utility was observed for chance of treatment success . | RESULTS | {"id": "21766893:7", "pmid": "21766893", "sentence_index": 7, "split_group_id": "21766893"} |
A significant negative impact on utility was observed for cost , weeks before exercise can be completed free of pain , chance of side effects ( p = 0.06 ) , and injections as a stand-alone treatment . | RESULTS | {"id": "21766893:8", "pmid": "21766893", "sentence_index": 8, "split_group_id": "21766893"} |
Respondents were willing to pay Australian dollars ( $ A ) 238 ( 95 % CI -312 , 788 ) for a 10 % increase in the chance of treatment success . | RESULTS | {"id": "21766893:9", "pmid": "21766893", "sentence_index": 9, "split_group_id": "21766893"} |
Study participants with Achilles tendon pain who had either participated or expressed an interest in participating in a randomized trial prefer a treatment that costs less , has a greater chance of success , has a shorter duration before being able to exercise free of pain , and has less likelihood of side effects . | CONCLUSIONS | {"id": "21766893:10", "pmid": "21766893", "sentence_index": 10, "split_group_id": "21766893"} |
On average , participants preferred exercises over injections as a stand-alone treatment . | CONCLUSIONS | {"id": "21766893:11", "pmid": "21766893", "sentence_index": 11, "split_group_id": "21766893"} |
Further research is required to confirm the findings in patients outside of the trial setting . | CONCLUSIONS | {"id": "21766893:12", "pmid": "21766893", "sentence_index": 12, "split_group_id": "21766893"} |
Nevertheless , this study contributes to an area that is deficient in research by identifying priorities and marginal willingness to pay for attributes related to Achilles tendinopathy . | CONCLUSIONS | {"id": "21766893:13", "pmid": "21766893", "sentence_index": 13, "split_group_id": "21766893"} |
Whether prasugrel plus bivalirudin is a superior strategy to unfractionated heparin plus clopidogrel in patients with ST-segment elevation myocardial infarction ( STEMI ) undergoing primary percutaneous coronary intervention ( PCI ) has never been assessed in specifically designed randomized trials . | OBJECTIVE | {"id": "24816809:0", "pmid": "24816809", "sentence_index": 0, "split_group_id": "24816809"} |
The Bavarian Reperfusion Alternatives Evaluation ( BRAVE ) 4 study is an investigator-initiated , randomized , open-label , multicentre trial , designed to test the hypothesis that in STEMI patients with planned primary PCI a strategy based on prasugrel plus bivalirudin is superior to a strategy based on clopidogrel pl... | RESULTS | {"id": "24816809:1", "pmid": "24816809", "sentence_index": 1, "split_group_id": "24816809"} |
Owing to slow recruitment , the trial was stopped prematurely after enrolment of 548 of 1240 planned patients . | RESULTS | {"id": "24816809:2", "pmid": "24816809", "sentence_index": 2, "split_group_id": "24816809"} |
At 30 days , the primary composite endpoint of death , myocardial infarction , unplanned revascularization of the infarct related artery , stent thrombosis , stroke , or bleeding was observed in 42 patients ( 15.6 % ) randomized to prasugrel plus bivalirudin and 40 patients ( 14.5 % ) randomized to clopidogrel plus hep... | RESULTS | {"id": "24816809:3", "pmid": "24816809", "sentence_index": 3, "split_group_id": "24816809"} |
The composite ischaemic endpoint of death , myocardial infarction , unplanned revascularization of the infarct-related artery , stent thrombosis , or stroke occurred in 13 patients ( 4.8 % ) in the prasugrel plus bivalirudin group and 15 patients ( 5.5 % ) in the clopidogrel plus heparin group ( relative risk , 0.89 ; ... | RESULTS | {"id": "24816809:4", "pmid": "24816809", "sentence_index": 4, "split_group_id": "24816809"} |
Bleeding according to the HORIZONS-AMI definition was observed in 38 patients ( 14.1 % ) in the prasugrel plus bivalirudin group and 33 patients ( 12.0 % ) in the clopidogrel plus heparin group ( relative risk , 1.18 ; 95 % CI 0.74-1 .88 , P = 0.543 ) . | RESULTS | {"id": "24816809:5", "pmid": "24816809", "sentence_index": 5, "split_group_id": "24816809"} |
Results were consistent across various subgroups of patients . | RESULTS | {"id": "24816809:6", "pmid": "24816809", "sentence_index": 6, "split_group_id": "24816809"} |
In this randomized trial of STEMI patients , we were unable to demonstrate significant differences in net clinical outcome between prasugrel plus bivalirudin and clopidogrel plus heparin . | CONCLUSIONS | {"id": "24816809:7", "pmid": "24816809", "sentence_index": 7, "split_group_id": "24816809"} |
Neither the composite of ischaemic complications nor bleeding were favourably affected by prasugrel plus bivalirudin compared with a regimen of clopidogrel plus unfractionated heparin . | CONCLUSIONS | {"id": "24816809:8", "pmid": "24816809", "sentence_index": 8, "split_group_id": "24816809"} |
However , the results must be interpreted in view of the premature termination of the trial . | CONCLUSIONS | {"id": "24816809:9", "pmid": "24816809", "sentence_index": 9, "split_group_id": "24816809"} |
Unique identifier NCT00976092 ( www.clinicaltrials.gov ) . | BACKGROUND | {"id": "24816809:10", "pmid": "24816809", "sentence_index": 10, "split_group_id": "24816809"} |
To evaluate the long-term recurrence rates and complication of different techniques of cervical ablation . | OBJECTIVE | {"id": "12551795:0", "pmid": "12551795", "sentence_index": 0, "split_group_id": "12551795"} |
A randomized trial of three techniques of conization ( cold knife , laser , and loop electrosurgical excisional procedure ( LEEP ) ) for cervical intraepithelial neoplasia ( CIN ) in which 110 patients had been recruited . | METHODS | {"id": "12551795:1", "pmid": "12551795", "sentence_index": 1, "split_group_id": "12551795"} |
Eighty-six patients were followed-up for more than 3 years . | RESULTS | {"id": "12551795:2", "pmid": "12551795", "sentence_index": 2, "split_group_id": "12551795"} |
Of these 28 had been treated with the cold knife , 29 with LEEP and 29 by laser . | RESULTS | {"id": "12551795:3", "pmid": "12551795", "sentence_index": 3, "split_group_id": "12551795"} |
Five recurrences were observed , one in the cold knife group , two in the LEEP group and two in the laser group ( P = NS ) . | RESULTS | {"id": "12551795:4", "pmid": "12551795", "sentence_index": 4, "split_group_id": "12551795"} |
The only observed complication was cervical stenosis : zero cases in the laser group , one case in the LEEP group and four cases in the cold knife group ( laser versus cold knife : P = 0.03 ; LEEP versus cold knife : P = 0.06 ) . | RESULTS | {"id": "12551795:5", "pmid": "12551795", "sentence_index": 5, "split_group_id": "12551795"} |
Fifty pregnancies were observed in 39 patients . | RESULTS | {"id": "12551795:6", "pmid": "12551795", "sentence_index": 6, "split_group_id": "12551795"} |
First and second trimester outcomes of pregnancy were without complications . | RESULTS | {"id": "12551795:7", "pmid": "12551795", "sentence_index": 7, "split_group_id": "12551795"} |
One patient treated with the LEEP presented with a premature rupture of membranes and premature labor at 36 weeks . | RESULTS | {"id": "12551795:8", "pmid": "12551795", "sentence_index": 8, "split_group_id": "12551795"} |
A total of nine cesarean sections were performed with two cases for cervical dystocia . | RESULTS | {"id": "12551795:9", "pmid": "12551795", "sentence_index": 9, "split_group_id": "12551795"} |
There is no major difference in obstetrical outcome between the three techniques . | CONCLUSIONS | {"id": "12551795:10", "pmid": "12551795", "sentence_index": 10, "split_group_id": "12551795"} |
To determine whether macronutrient composition of a hypocaloric diet can enhance its effectiveness and whether insulin sensitivity ( Si ) affects the response to hypocaloric diets . | OBJECTIVE | {"id": "15897479:0", "pmid": "15897479", "sentence_index": 0, "split_group_id": "15897479"} |
Obese nondiabetic insulin-sensitive ( fasting insulin < 10 microU/mL ; n = 12 ) and obese nondiabetic insulin-resistant ( fasting insulin > 15 microU/mL ; n = 9 ) women ( 23 to 53 years old ) were randomized to either a high carbohydrate ( CHO ) ( HC ) / low fat ( LF ) ( 60 % CHO , 20 % fat ) or low CHO ( LC ) / high f... | METHODS | {"id": "15897479:1", "pmid": "15897479", "sentence_index": 1, "split_group_id": "15897479"} |
Primary outcome measures after a 16-week dietary intervention were : changes in body weight ( BW ) , Si , resting metabolic rate , and fasting lipids . | METHODS | {"id": "15897479:2", "pmid": "15897479", "sentence_index": 2, "split_group_id": "15897479"} |
Insulin-sensitive women on the HC/LF diet lost 13.5 + / - 1.2 % ( p < 0.001 ) of their initial BW , whereas those on the LC/HF diet lost 6.8 + / - 1.2 % ( p < 0.001 ; p < 0.002 between the groups ) . | RESULTS | {"id": "15897479:3", "pmid": "15897479", "sentence_index": 3, "split_group_id": "15897479"} |
In contrast , among the insulin-resistant women , those on the LC/HF diet lost 13.4 + / - 1.3 % ( p < 0.001 ) of their initial BW as compared with 8.5 + / - 1.4 % ( p < 0.001 ) lost by those on the HC/LF diet ( p < 0.04 between two groups ) . | RESULTS | {"id": "15897479:4", "pmid": "15897479", "sentence_index": 4, "split_group_id": "15897479"} |
These differences could not be explained by changes in resting metabolic rate , activity , or intake . | RESULTS | {"id": "15897479:5", "pmid": "15897479", "sentence_index": 5, "split_group_id": "15897479"} |
Overall , changes in Si were associated with the degree of weight loss ( r = -0.57 , p < 0.05 ) . | RESULTS | {"id": "15897479:6", "pmid": "15897479", "sentence_index": 6, "split_group_id": "15897479"} |
The state of Si determines the effectiveness of macronutrient composition of hypocaloric diets in obese women . | CONCLUSIONS | {"id": "15897479:7", "pmid": "15897479", "sentence_index": 7, "split_group_id": "15897479"} |
For maximal benefit , the macronutrient composition of a hypocaloric diet may need to be adjusted to correspond to the state of Si . | CONCLUSIONS | {"id": "15897479:8", "pmid": "15897479", "sentence_index": 8, "split_group_id": "15897479"} |
To compare the effects of dry needling of myofascial trigger points in the neck region to metoprolol in migraine prophylaxis . | OBJECTIVE | {"id": "8182401:0", "pmid": "8182401", "sentence_index": 0, "split_group_id": "8182401"} |
Randomized , group comparative study . | METHODS | {"id": "8182401:1", "pmid": "8182401", "sentence_index": 1, "split_group_id": "8182401"} |
patients , investigator and statistician were blinded as to treatment , the therapist was blinded as to results . | METHODS | {"id": "8182401:2", "pmid": "8182401", "sentence_index": 2, "split_group_id": "8182401"} |
Outpatient pain clinic in the northern Copenhagen area . | METHODS | {"id": "8182401:3", "pmid": "8182401", "sentence_index": 3, "split_group_id": "8182401"} |
Patients were referred by general practitioners or respondents to newspaper advertisements . | METHODS | {"id": "8182401:4", "pmid": "8182401", "sentence_index": 4, "split_group_id": "8182401"} |
Included were patients with a history of migraine with or without aura for at least 2 years . | METHODS | {"id": "8182401:5", "pmid": "8182401", "sentence_index": 5, "split_group_id": "8182401"} |
Excluded were persons with contraindications against treatment with beta blockers , chronic pain syndromes , pregnancy or previous experience with acupuncture or beta-blocking agents . | METHODS | {"id": "8182401:6", "pmid": "8182401", "sentence_index": 6, "split_group_id": "8182401"} |
A total of 85 patients were included ; 77 completed the study . | METHODS | {"id": "8182401:7", "pmid": "8182401", "sentence_index": 7, "split_group_id": "8182401"} |
After a 4-week run-in period , patients were allocated to a 17-week regimen either with acupuncture and placebo tablets or to placebo stimulation and metoprolol 100 mg daily . | METHODS | {"id": "8182401:8", "pmid": "8182401", "sentence_index": 8, "split_group_id": "8182401"} |
Both groups exhibited significant reduction in attack frequency ( P < 0.01 ) . | RESULTS | {"id": "8182401:9", "pmid": "8182401", "sentence_index": 9, "split_group_id": "8182401"} |
No difference was found between the groups regarding frequency ( P > 0.20 ) or duration ( P > 0.10 ) of attacks , whereas we found a significant difference in global rating of attacks in favour of metoprolol ( P < 0.05 ) . | RESULTS | {"id": "8182401:10", "pmid": "8182401", "sentence_index": 10, "split_group_id": "8182401"} |
Trigger point inactivation by dry needling is a valuable supplement to the list of migraine prophylactic tools , being equipotent to metoprolol in the influence on frequency and duration ( but not severity ) of attacks , and superior in terms of negative side-effects . | CONCLUSIONS | {"id": "8182401:11", "pmid": "8182401", "sentence_index": 11, "split_group_id": "8182401"} |
This study aimed to evaluate the effects of monophasic estrogen-progestogen therapy on the sexuality and climacteric symptoms of postmenopausal women . | OBJECTIVE | {"id": "17217318:0", "pmid": "17217318", "sentence_index": 0, "split_group_id": "17217318"} |
A prospective , randomised , double-blind , crossover , placebo-controlled , single-centre study was carried out over a total of 12 consecutive months in 40 postmenopausal women with an intact uterus who had no contraindications to hormone therapy . | METHODS | {"id": "17217318:1", "pmid": "17217318", "sentence_index": 1, "split_group_id": "17217318"} |
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