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['PMC8253860'] | ['34215730'] | ['Tab1', 'MOESM1', 'MOESM1', 'Fig1', 'Fig1', 'Fig1', 'Fig1', 'MOESM1', 'MOESM1', 'MOESM1', 'MOESM1', 'MOESM1', 'MOESM1'] | To determine how the TCR repertoire of TIL/Tc influenced PD1 CPB outcome, we analyzed pre-treatment biopsies from 16 metastatic melanoma patients who received anti-PD1 agents in Manchester, Padova, and Meldola (Table1). There were no differences in total TIL/Tc numbers, the number of TIL/Tc clones, or the diversity and... | PMC8253860 | Article | null | 34,215,730 | The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival | Valpione S, Mundra PA, Galvani E, Campana LG, Lorigan P, De Rosa F, Gupta A, Weightman J, Mills S, Dhomen N, Marais R. | Nat Commun. 2021 Jul 2;12(1):4098. doi: 10.1038/s41467-021-24343-x. | Valpione S | Nat Commun | 2,021 | 2021/07/03 | PMC8253860 | null | 10.1038/s41467-021-24343-x | oa_comm/txt/all/PMC8253860.txt | e274a0dfd85bc286f7cf65b296798129 | Nat Commun. 2021 Jul 2; 12:4098 | 2021-09-04 06:53:28 | CC BY | no |
['PMC8253860'] | ['34215730'] | [] | ASurvival curves for our metastatic melanoma training cohort of patients treated with anti-PD1 drugs with high (green) or low (orange) pre-treatment TIL/Tc clonality (n= 16, cut-off = 0.06, log-rankP= 0.0003),Bpredictive effect of TIL/Tc clonality on the relative hazard for death in the same cohort asA.Y-axis: log of r... | PMC8253860 | Article | null | 34,215,730 | The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival | Valpione S, Mundra PA, Galvani E, Campana LG, Lorigan P, De Rosa F, Gupta A, Weightman J, Mills S, Dhomen N, Marais R. | Nat Commun. 2021 Jul 2;12(1):4098. doi: 10.1038/s41467-021-24343-x. | Valpione S | Nat Commun | 2,021 | 2021/07/03 | PMC8253860 | null | 10.1038/s41467-021-24343-x | oa_comm/txt/all/PMC8253860.txt | e274a0dfd85bc286f7cf65b296798129 | Nat Commun. 2021 Jul 2; 12:4098 | 2021-09-04 06:53:28 | CC BY | no |
['PMC8253860'] | ['34215730'] | ['Fig2', 'MOESM1', 'MOESM1', 'Fig2', 'Fig2', 'MOESM1'] | To test whether high TIL/Tc TCR clonality also correlated to prognosis in melanoma patients who did not receive PD1 CPB, we analyzed the TIL/Tc TCR repertoire in The Cancer Genome Atlas (TCGA) melanoma cohort11, because the data-lock for these samples predated approval of anti-PD1 inhibitors. As expected, in multivaria... | PMC8253860 | Article | null | 34,215,730 | The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival | Valpione S, Mundra PA, Galvani E, Campana LG, Lorigan P, De Rosa F, Gupta A, Weightman J, Mills S, Dhomen N, Marais R. | Nat Commun. 2021 Jul 2;12(1):4098. doi: 10.1038/s41467-021-24343-x. | Valpione S | Nat Commun | 2,021 | 2021/07/03 | PMC8253860 | null | 10.1038/s41467-021-24343-x | oa_comm/txt/all/PMC8253860.txt | e274a0dfd85bc286f7cf65b296798129 | Nat Commun. 2021 Jul 2; 12:4098 | 2021-09-04 06:53:28 | CC BY | no |
['PMC8253860'] | ['34215730'] | ['MOESM1'] | Analyses of TCGA skin melanoma cohort (n= 412):Aforest plot showing HR and 95% CI for significant covariates retained in the multivariate Cox regression prognostic model calculated using the fast-backward method and the Akaike Information Criterion as a stopping rule (events = 147, model for OS globalP< 0.001, concorda... | PMC8253860 | Article | null | 34,215,730 | The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival | Valpione S, Mundra PA, Galvani E, Campana LG, Lorigan P, De Rosa F, Gupta A, Weightman J, Mills S, Dhomen N, Marais R. | Nat Commun. 2021 Jul 2;12(1):4098. doi: 10.1038/s41467-021-24343-x. | Valpione S | Nat Commun | 2,021 | 2021/07/03 | PMC8253860 | null | 10.1038/s41467-021-24343-x | oa_comm/txt/all/PMC8253860.txt | e274a0dfd85bc286f7cf65b296798129 | Nat Commun. 2021 Jul 2; 12:4098 | 2021-09-04 06:53:28 | CC BY | no |
['PMC8253860'] | ['34215730'] | ['Fig3', 'MOESM1', 'MOESM1', 'Fig3', 'MOESM1'] | Since PD1 CPB is now standard of care for melanoma in the adjuvant and metastatic settings, prospective analysis of anti-PD1 naive melanoma patients who will not receive CPB in their clinical history is no longer feasible, so we examined TIL/Tc TCR diversity and clonality in other TCGA cancer cohorts. This also allowed... | PMC8253860 | Article | null | 34,215,730 | The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival | Valpione S, Mundra PA, Galvani E, Campana LG, Lorigan P, De Rosa F, Gupta A, Weightman J, Mills S, Dhomen N, Marais R. | Nat Commun. 2021 Jul 2;12(1):4098. doi: 10.1038/s41467-021-24343-x. | Valpione S | Nat Commun | 2,021 | 2021/07/03 | PMC8253860 | null | 10.1038/s41467-021-24343-x | oa_comm/txt/all/PMC8253860.txt | e274a0dfd85bc286f7cf65b296798129 | Nat Commun. 2021 Jul 2; 12:4098 | 2021-09-04 06:53:28 | CC BY | no |
['PMC8253860'] | ['34215730'] | [] | A–LAnalyses of the TCGA cancer cohorts.AEstimated total number of tumor-infiltrating T cells (TIL/Tc) in the cancer cohorts; the cohorts above the upper quartile of TIL/Tc are highlighted in blue;B–Gsurvival curves for the cancer cohorts with abundant TIL/Tc fromAof patients with high (blue) or low (pink) TIL diversity... | PMC8253860 | Article | null | 34,215,730 | The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival | Valpione S, Mundra PA, Galvani E, Campana LG, Lorigan P, De Rosa F, Gupta A, Weightman J, Mills S, Dhomen N, Marais R. | Nat Commun. 2021 Jul 2;12(1):4098. doi: 10.1038/s41467-021-24343-x. | Valpione S | Nat Commun | 2,021 | 2021/07/03 | PMC8253860 | null | 10.1038/s41467-021-24343-x | oa_comm/txt/all/PMC8253860.txt | e274a0dfd85bc286f7cf65b296798129 | Nat Commun. 2021 Jul 2; 12:4098 | 2021-09-04 06:53:28 | CC BY | no |
['PMC8253860'] | ['34215730'] | [] | Our data shows that, as in melanoma, in various other cancers TIL/Tc diversity is prognostic for OS in the absence of PD1 blockade, whereas pre-treatment TIL/Tc clonality is predictive of response to anti-PD1 treatment. This is consistent with observations that on-treatment TIL/Tc clonality anticipates radiological res... | PMC8253860 | Article | null | 34,215,730 | The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival | Valpione S, Mundra PA, Galvani E, Campana LG, Lorigan P, De Rosa F, Gupta A, Weightman J, Mills S, Dhomen N, Marais R. | Nat Commun. 2021 Jul 2;12(1):4098. doi: 10.1038/s41467-021-24343-x. | Valpione S | Nat Commun | 2,021 | 2021/07/03 | PMC8253860 | null | 10.1038/s41467-021-24343-x | oa_comm/txt/all/PMC8253860.txt | e274a0dfd85bc286f7cf65b296798129 | Nat Commun. 2021 Jul 2; 12:4098 | 2021-09-04 06:53:28 | CC BY | no |
['PMC8253860'] | ['34215730'] | [] | The training cohort patient samples do not involve clinical trials/clinical trial-associated data, as patient samples were collected prior to standard-of-care treatment. Biopsy pre-treatment samples from Manchester patients were prospectively collected under the Manchester Cancer Research Centre (MCRC) Biobank ethics a... | PMC8253860 | Article | null | 34,215,730 | The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival | Valpione S, Mundra PA, Galvani E, Campana LG, Lorigan P, De Rosa F, Gupta A, Weightman J, Mills S, Dhomen N, Marais R. | Nat Commun. 2021 Jul 2;12(1):4098. doi: 10.1038/s41467-021-24343-x. | Valpione S | Nat Commun | 2,021 | 2021/07/03 | PMC8253860 | null | 10.1038/s41467-021-24343-x | oa_comm/txt/all/PMC8253860.txt | e274a0dfd85bc286f7cf65b296798129 | Nat Commun. 2021 Jul 2; 12:4098 | 2021-09-04 06:53:28 | CC BY | no |
['PMC8253860'] | ['34215730'] | [] | RNA was extracted from pre-treatment human fresh frozen tumor samples using the AllPrep DNA/RNA Kit (Qiagen, Manchester, UK) according to the manufacturer’s instructions: briefly, tissue samples were first lysed and homogenized in a highly denaturing guanidineisothiocyanate-containing buffer to inactivate DNases and RN... | PMC8253860 | Article | null | 34,215,730 | The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival | Valpione S, Mundra PA, Galvani E, Campana LG, Lorigan P, De Rosa F, Gupta A, Weightman J, Mills S, Dhomen N, Marais R. | Nat Commun. 2021 Jul 2;12(1):4098. doi: 10.1038/s41467-021-24343-x. | Valpione S | Nat Commun | 2,021 | 2021/07/03 | PMC8253860 | null | 10.1038/s41467-021-24343-x | oa_comm/txt/all/PMC8253860.txt | e274a0dfd85bc286f7cf65b296798129 | Nat Commun. 2021 Jul 2; 12:4098 | 2021-09-04 06:53:28 | CC BY | no |
['PMC8253860'] | ['34215730'] | [] | CDR3 TCR sequence data generated by Bo Li et al.11for the 29 TCGA cohorts were kindly made available by the authors; the clinical data for the cohorts were downloaded from cBioportal in February 2018. CDR3 TCR sequences were inferred from RNA Seq data from pre-treatment biopsies for the training cohort samples using Im... | PMC8253860 | Article | null | 34,215,730 | The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival | Valpione S, Mundra PA, Galvani E, Campana LG, Lorigan P, De Rosa F, Gupta A, Weightman J, Mills S, Dhomen N, Marais R. | Nat Commun. 2021 Jul 2;12(1):4098. doi: 10.1038/s41467-021-24343-x. | Valpione S | Nat Commun | 2,021 | 2021/07/03 | PMC8253860 | null | 10.1038/s41467-021-24343-x | oa_comm/txt/all/PMC8253860.txt | e274a0dfd85bc286f7cf65b296798129 | Nat Commun. 2021 Jul 2; 12:4098 | 2021-09-04 06:53:28 | CC BY | no |
['PMC8253860'] | ['34215730'] | [] | Mutational signatures for TCGA SKCM cohort were determined by fitting somatic SNVs with tri-nucleotide context to the 30 COSMIC mutational signatures using deconstructSigs12package using default parameters. Signatures with contribution weights <6% were excluded. | PMC8253860 | Article | null | 34,215,730 | The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival | Valpione S, Mundra PA, Galvani E, Campana LG, Lorigan P, De Rosa F, Gupta A, Weightman J, Mills S, Dhomen N, Marais R. | Nat Commun. 2021 Jul 2;12(1):4098. doi: 10.1038/s41467-021-24343-x. | Valpione S | Nat Commun | 2,021 | 2021/07/03 | PMC8253860 | null | 10.1038/s41467-021-24343-x | oa_comm/txt/all/PMC8253860.txt | e274a0dfd85bc286f7cf65b296798129 | Nat Commun. 2021 Jul 2; 12:4098 | 2021-09-04 06:53:28 | CC BY | no |
['PMC8253860'] | ['34215730'] | [] | Pre-treatment biopsy samples were fixed in 10% neutral buffered formalin (Sigma-Aldrich), processed, and embedded in paraffin wax. Samples were sectioned (4 μm) and stained with hematoxylin and eosin using standard protocols. Formalin-fixed paraffin-embedded sections were deparaffinized using xylene and rehydrated pass... | PMC8253860 | Article | null | 34,215,730 | The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival | Valpione S, Mundra PA, Galvani E, Campana LG, Lorigan P, De Rosa F, Gupta A, Weightman J, Mills S, Dhomen N, Marais R. | Nat Commun. 2021 Jul 2;12(1):4098. doi: 10.1038/s41467-021-24343-x. | Valpione S | Nat Commun | 2,021 | 2021/07/03 | PMC8253860 | null | 10.1038/s41467-021-24343-x | oa_comm/txt/all/PMC8253860.txt | e274a0dfd85bc286f7cf65b296798129 | Nat Commun. 2021 Jul 2; 12:4098 | 2021-09-04 06:53:28 | CC BY | no |
['PMC8253860'] | ['34215730'] | ['Fig3', 'Fig2', 'Fig3'] | All tests were two-sided andPvalues < 0.05 were retained as significant. Unless otherwise specified, multivariate Cox regression was used to calculate the hazard of death; fast-backward method was applied to select the covariates retained in the multivariate models (fastbwfunction inrmsR package,type=“individual”). The... | PMC8253860 | Article | null | 34,215,730 | The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival | Valpione S, Mundra PA, Galvani E, Campana LG, Lorigan P, De Rosa F, Gupta A, Weightman J, Mills S, Dhomen N, Marais R. | Nat Commun. 2021 Jul 2;12(1):4098. doi: 10.1038/s41467-021-24343-x. | Valpione S | Nat Commun | 2,021 | 2021/07/03 | PMC8253860 | null | 10.1038/s41467-021-24343-x | oa_comm/txt/all/PMC8253860.txt | e274a0dfd85bc286f7cf65b296798129 | Nat Commun. 2021 Jul 2; 12:4098 | 2021-09-04 06:53:28 | CC BY | no |
['PMC8253860'] | ['34215730'] | ['MOESM3'] | Further information on research design is available in theNature Research Reporting Summarylinked to this article. | PMC8253860 | Article | null | 34,215,730 | The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival | Valpione S, Mundra PA, Galvani E, Campana LG, Lorigan P, De Rosa F, Gupta A, Weightman J, Mills S, Dhomen N, Marais R. | Nat Commun. 2021 Jul 2;12(1):4098. doi: 10.1038/s41467-021-24343-x. | Valpione S | Nat Commun | 2,021 | 2021/07/03 | PMC8253860 | null | 10.1038/s41467-021-24343-x | oa_comm/txt/all/PMC8253860.txt | e274a0dfd85bc286f7cf65b296798129 | Nat Commun. 2021 Jul 2; 12:4098 | 2021-09-04 06:53:28 | CC BY | no |
['PMC10954323'] | ['37882611'] | ['ciad656-B15', 'ciad656-B15', 'ciad656-B15', 'ciad656-B16'] | This was a 2-arm, open-label, nonrandomized, multicenter pharmacokinetic substudy with descriptive safety and efficacy analysis of the EMPIRICAL randomized, controlled trial (NCT03915366) that aims to determine whether empirical treatment for cytomegalovirus and TB improves the survival of infants with HIV who are admi... | PMC10954323 | Major Article; HIV/AIDs; AcademicSubjects/MED00290 | null | 37,882,611 | Twice-Daily Dosing of Dolutegravir in Infants on Rifampicin Treatment: A Pharmacokinetic Substudy of the EMPIRICAL Trial | Jacobs TG, Mumbiro V, Cassia U, Zimba K, Nalwanga D, Ballesteros A, Domínguez-Rodríguez S, Tagarro A, Madrid L, Mutata C, Chitsamatanga M, Bwakura-Dangarembizi M, Passanduca A, Buck WC, Nduna B, Chabala C, Najjingo E, Musiime V, Moraleda C, Colbers A, Mujuru HA, Rojo P, Burger DM; EMPIRICAL Clinical Trial Group. | Clin Infect Dis. 2024 Mar 20;78(3):702-710. doi: 10.1093/cid/ciad656. | Jacobs TG | Clin Infect Dis | 2,024 | 2023/10/26 | PMC10954323 | null | 10.1093/cid/ciad656 | oa_comm/txt/all/PMC10954323.txt | 7b161aded446bfee04adef90e2bb4fe3 | Clin Infect Dis. 2023 Oct 26; 78(3):702-710 | 2024-07-20 23:20:26 | CC BY | no |
['PMC10954323'] | ['37882611'] | ['ciad656-B6', 'ciad656-B17', 'ciad656-B18', 'ciad656-B19', 'ciad656-B14'] | All infants received dolutegravir 10 mg scored DTs with abacavir/lamivudine, following national guidelines. Dosing of dolutegravir followed the WHO weight bands; children weighing 3 to <6 kg and 6 to <10 kg were administered 0.5 and 1.5 dolutegravir 10 mg DTs, respectively, with the dose frequency increased from OD to ... | PMC10954323 | Major Article; HIV/AIDs; AcademicSubjects/MED00290 | null | 37,882,611 | Twice-Daily Dosing of Dolutegravir in Infants on Rifampicin Treatment: A Pharmacokinetic Substudy of the EMPIRICAL Trial | Jacobs TG, Mumbiro V, Cassia U, Zimba K, Nalwanga D, Ballesteros A, Domínguez-Rodríguez S, Tagarro A, Madrid L, Mutata C, Chitsamatanga M, Bwakura-Dangarembizi M, Passanduca A, Buck WC, Nduna B, Chabala C, Najjingo E, Musiime V, Moraleda C, Colbers A, Mujuru HA, Rojo P, Burger DM; EMPIRICAL Clinical Trial Group. | Clin Infect Dis. 2024 Mar 20;78(3):702-710. doi: 10.1093/cid/ciad656. | Jacobs TG | Clin Infect Dis | 2,024 | 2023/10/26 | PMC10954323 | null | 10.1093/cid/ciad656 | oa_comm/txt/all/PMC10954323.txt | 7b161aded446bfee04adef90e2bb4fe3 | Clin Infect Dis. 2023 Oct 26; 78(3):702-710 | 2024-07-20 23:20:26 | CC BY | no |
['PMC10954323'] | ['37882611'] | ['ciad656-B11', 'ciad656-B20', 'ciad656-B21', 'ciad656-B22', 'ciad656-B23'] | Dolutegravir and dolutegravir-glucuronide pharmacokinetic parameters were determined with noncompartmental pharmacokinetic analysis using WinNonlin (Phoenix 64 v8.3, Certara) and were described as geometric mean with an associated coefficient of variance. Similar to previous studies, pharmacokinetic profiles were consi... | PMC10954323 | Major Article; HIV/AIDs; AcademicSubjects/MED00290 | null | 37,882,611 | Twice-Daily Dosing of Dolutegravir in Infants on Rifampicin Treatment: A Pharmacokinetic Substudy of the EMPIRICAL Trial | Jacobs TG, Mumbiro V, Cassia U, Zimba K, Nalwanga D, Ballesteros A, Domínguez-Rodríguez S, Tagarro A, Madrid L, Mutata C, Chitsamatanga M, Bwakura-Dangarembizi M, Passanduca A, Buck WC, Nduna B, Chabala C, Najjingo E, Musiime V, Moraleda C, Colbers A, Mujuru HA, Rojo P, Burger DM; EMPIRICAL Clinical Trial Group. | Clin Infect Dis. 2024 Mar 20;78(3):702-710. doi: 10.1093/cid/ciad656. | Jacobs TG | Clin Infect Dis | 2,024 | 2023/10/26 | PMC10954323 | null | 10.1093/cid/ciad656 | oa_comm/txt/all/PMC10954323.txt | 7b161aded446bfee04adef90e2bb4fe3 | Clin Infect Dis. 2023 Oct 26; 78(3):702-710 | 2024-07-20 23:20:26 | CC BY | no |
['PMC10954323'] | ['37882611'] | ['ciad656-F1', 'ciad656-T1'] | A total of 30 infants were recruited between August 2021 and August 2022 (seeFigure 1for the study profile). Of these, 27 had evaluable pharmacokinetic profiles with a median (interquartile range) age of 7.1 months (6.1–9.9), weighing 6.3 kg (5.6–7.2), and 11 of 27 (41%) were female. Nonevaluable pharmacokinetic profil... | PMC10954323 | Major Article; HIV/AIDs; AcademicSubjects/MED00290 | null | 37,882,611 | Twice-Daily Dosing of Dolutegravir in Infants on Rifampicin Treatment: A Pharmacokinetic Substudy of the EMPIRICAL Trial | Jacobs TG, Mumbiro V, Cassia U, Zimba K, Nalwanga D, Ballesteros A, Domínguez-Rodríguez S, Tagarro A, Madrid L, Mutata C, Chitsamatanga M, Bwakura-Dangarembizi M, Passanduca A, Buck WC, Nduna B, Chabala C, Najjingo E, Musiime V, Moraleda C, Colbers A, Mujuru HA, Rojo P, Burger DM; EMPIRICAL Clinical Trial Group. | Clin Infect Dis. 2024 Mar 20;78(3):702-710. doi: 10.1093/cid/ciad656. | Jacobs TG | Clin Infect Dis | 2,024 | 2023/10/26 | PMC10954323 | null | 10.1093/cid/ciad656 | oa_comm/txt/all/PMC10954323.txt | 7b161aded446bfee04adef90e2bb4fe3 | Clin Infect Dis. 2023 Oct 26; 78(3):702-710 | 2024-07-20 23:20:26 | CC BY | no |
['PMC10954323'] | ['37882611'] | ['ciad656-F2', 'ciad656-F3', 'ciad656-T2', 'ciad656-T2', 'sup1'] | The dolutegravir plasma concentration-time curves for the 2 study groups are displayed inFigure 2. One of 21 infants receiving rifampicin and none of 6 infants without rifampicin had a dolutegravir Ctroughbelow the EC90target (dolutegravir, 0.32 mg/L), and none of the participants had a Ctroughbelow the IC90target (dol... | PMC10954323 | Major Article; HIV/AIDs; AcademicSubjects/MED00290 | null | 37,882,611 | Twice-Daily Dosing of Dolutegravir in Infants on Rifampicin Treatment: A Pharmacokinetic Substudy of the EMPIRICAL Trial | Jacobs TG, Mumbiro V, Cassia U, Zimba K, Nalwanga D, Ballesteros A, Domínguez-Rodríguez S, Tagarro A, Madrid L, Mutata C, Chitsamatanga M, Bwakura-Dangarembizi M, Passanduca A, Buck WC, Nduna B, Chabala C, Najjingo E, Musiime V, Moraleda C, Colbers A, Mujuru HA, Rojo P, Burger DM; EMPIRICAL Clinical Trial Group. | Clin Infect Dis. 2024 Mar 20;78(3):702-710. doi: 10.1093/cid/ciad656. | Jacobs TG | Clin Infect Dis | 2,024 | 2023/10/26 | PMC10954323 | null | 10.1093/cid/ciad656 | oa_comm/txt/all/PMC10954323.txt | 7b161aded446bfee04adef90e2bb4fe3 | Clin Infect Dis. 2023 Oct 26; 78(3):702-710 | 2024-07-20 23:20:26 | CC BY | no |
['PMC10954323'] | ['37882611'] | ['ciad656-T3', 'sup1', 'ciad656-F4'] | During the 180-day follow-up period, 82 AEs were reported (summarized inTable 3). Four of 21 infants (19%) experienced an AE, of which 2 were SAEs (liver abnormalities) that were potentially related to rifampicin, and 1 of 27 infants (4%) experienced an AE that was possibly related to dolutegravir. All 5 successfully r... | PMC10954323 | Major Article; HIV/AIDs; AcademicSubjects/MED00290 | null | 37,882,611 | Twice-Daily Dosing of Dolutegravir in Infants on Rifampicin Treatment: A Pharmacokinetic Substudy of the EMPIRICAL Trial | Jacobs TG, Mumbiro V, Cassia U, Zimba K, Nalwanga D, Ballesteros A, Domínguez-Rodríguez S, Tagarro A, Madrid L, Mutata C, Chitsamatanga M, Bwakura-Dangarembizi M, Passanduca A, Buck WC, Nduna B, Chabala C, Najjingo E, Musiime V, Moraleda C, Colbers A, Mujuru HA, Rojo P, Burger DM; EMPIRICAL Clinical Trial Group. | Clin Infect Dis. 2024 Mar 20;78(3):702-710. doi: 10.1093/cid/ciad656. | Jacobs TG | Clin Infect Dis | 2,024 | 2023/10/26 | PMC10954323 | null | 10.1093/cid/ciad656 | oa_comm/txt/all/PMC10954323.txt | 7b161aded446bfee04adef90e2bb4fe3 | Clin Infect Dis. 2023 Oct 26; 78(3):702-710 | 2024-07-20 23:20:26 | CC BY | no |
['PMC10954323'] | ['37882611'] | ['ciad656-B24', 'ciad656-B25', 'ciad656-B6', 'ciad656-B26', 'ciad656-B4', 'ciad656-B27', 'ciad656-B28', 'ciad656-B4', 'ciad656-B6', 'ciad656-B22', 'ciad656-B29', 'ciad656-B23', 'ciad656-B7', 'ciad656-B30', 'ciad656-B33', 'ciad656-B34', 'ciad656-B35', 'ciad656-B36', 'ciad656-B37', 'ciad656-B38', 'ciad656-B39', 'ciad656-... | To our knowledge, we are the first to report dolutegravir pharmacokinetic data and descriptive safety and efficacy for infants receiving concomitant rifampicin. Our findings showed that BID dosing of dolutegravir in the presence of rifampicin resulted in adequate dolutegravir exposure. The geometric mean Ctroughwas sim... | PMC10954323 | Major Article; HIV/AIDs; AcademicSubjects/MED00290 | null | 37,882,611 | Twice-Daily Dosing of Dolutegravir in Infants on Rifampicin Treatment: A Pharmacokinetic Substudy of the EMPIRICAL Trial | Jacobs TG, Mumbiro V, Cassia U, Zimba K, Nalwanga D, Ballesteros A, Domínguez-Rodríguez S, Tagarro A, Madrid L, Mutata C, Chitsamatanga M, Bwakura-Dangarembizi M, Passanduca A, Buck WC, Nduna B, Chabala C, Najjingo E, Musiime V, Moraleda C, Colbers A, Mujuru HA, Rojo P, Burger DM; EMPIRICAL Clinical Trial Group. | Clin Infect Dis. 2024 Mar 20;78(3):702-710. doi: 10.1093/cid/ciad656. | Jacobs TG | Clin Infect Dis | 2,024 | 2023/10/26 | PMC10954323 | null | 10.1093/cid/ciad656 | oa_comm/txt/all/PMC10954323.txt | 7b161aded446bfee04adef90e2bb4fe3 | Clin Infect Dis. 2023 Oct 26; 78(3):702-710 | 2024-07-20 23:20:26 | CC BY | no |
['PMC10954323'] | ['37882611'] | ['sup1'] | Supplementary materialsare available atClinical Infectious Diseasesonline. Consisting of data provided by the authors to benefit the reader, the posted materials are not copyedited and are the sole responsibility of the authors, so questions or comments should be addressed to the corresponding author. | PMC10954323 | Major Article; HIV/AIDs; AcademicSubjects/MED00290 | null | 37,882,611 | Twice-Daily Dosing of Dolutegravir in Infants on Rifampicin Treatment: A Pharmacokinetic Substudy of the EMPIRICAL Trial | Jacobs TG, Mumbiro V, Cassia U, Zimba K, Nalwanga D, Ballesteros A, Domínguez-Rodríguez S, Tagarro A, Madrid L, Mutata C, Chitsamatanga M, Bwakura-Dangarembizi M, Passanduca A, Buck WC, Nduna B, Chabala C, Najjingo E, Musiime V, Moraleda C, Colbers A, Mujuru HA, Rojo P, Burger DM; EMPIRICAL Clinical Trial Group. | Clin Infect Dis. 2024 Mar 20;78(3):702-710. doi: 10.1093/cid/ciad656. | Jacobs TG | Clin Infect Dis | 2,024 | 2023/10/26 | PMC10954323 | null | 10.1093/cid/ciad656 | oa_comm/txt/all/PMC10954323.txt | 7b161aded446bfee04adef90e2bb4fe3 | Clin Infect Dis. 2023 Oct 26; 78(3):702-710 | 2024-07-20 23:20:26 | CC BY | no |
['PMC7212579'] | ['32393349'] | ['CR1', 'CR2', 'CR3', 'CR4', 'CR5', 'CR6', 'CR7', 'CR8', 'CR9', 'CR11', 'CR12', 'CR13', 'CR16'] | Oral diseases constitute a major burden of chronic disease, collectively impacting half of the global population [1]. Leading causes of oral disease include dental caries, which affect a third of the population; gingivitis, a highly prevalent condition in children and adults; and severe periodontitis, a major cause of ... | PMC7212579 | Research Article | null | 32,393,349 | Feasibility of training community health workers to conduct periodontal examinations: a validation study in rural Nepal | Erchick DJ, Agrawal NK, Khatry SK, Katz J, LeClerq SC, Rai B, Reynolds MA, Mullany LC. | BMC Health Serv Res. 2020 May 11;20(1):412. doi: 10.1186/s12913-020-05276-5. | Erchick DJ | BMC Health Serv Res | 2,020 | 2020/05/13 | PMC7212579 | null | 10.1186/s12913-020-05276-5 | oa_comm/txt/all/PMC7212579.txt | 5f1f18b5ab62b9fed67d8ea3cd98e07f | BMC Health Serv Res. 2020 May 11; 20:412 | 2021-06-19 05:27:54 | CC BY | no |
['PMC7212579'] | ['32393349'] | ['Fig1'] | We recruited twenty-one pregnant women < 26 weeks gestation in a sub-area of Sarlahi District, Nepal, between January and November 2016. These women were enrolled in a community-based, prospective cohort study of maternal gingival inflammation and adverse pregnancy outcomes. Participants in this study were identified a... | PMC7212579 | Research Article | null | 32,393,349 | Feasibility of training community health workers to conduct periodontal examinations: a validation study in rural Nepal | Erchick DJ, Agrawal NK, Khatry SK, Katz J, LeClerq SC, Rai B, Reynolds MA, Mullany LC. | BMC Health Serv Res. 2020 May 11;20(1):412. doi: 10.1186/s12913-020-05276-5. | Erchick DJ | BMC Health Serv Res | 2,020 | 2020/05/13 | PMC7212579 | null | 10.1186/s12913-020-05276-5 | oa_comm/txt/all/PMC7212579.txt | 5f1f18b5ab62b9fed67d8ea3cd98e07f | BMC Health Serv Res. 2020 May 11; 20:412 | 2021-06-19 05:27:54 | CC BY | no |
['PMC7212579'] | ['32393349'] | ['Tab1', 'Tab2', 'Fig2', 'Tab3', 'MOESM1', 'Tab4', 'Tab5'] | Twenty-one pregnant women < 26 weeks gestation were enrolled in this study. The mean age of participants was 22 (SD: ±3) years (Table1). A majority of women (62%) were literate, 38% had no education, 38% 1–9 years of schooling, and 24% 10 or more years. Nearly three-quarters (71%) of participants lived in a house const... | PMC7212579 | Research Article | null | 32,393,349 | Feasibility of training community health workers to conduct periodontal examinations: a validation study in rural Nepal | Erchick DJ, Agrawal NK, Khatry SK, Katz J, LeClerq SC, Rai B, Reynolds MA, Mullany LC. | BMC Health Serv Res. 2020 May 11;20(1):412. doi: 10.1186/s12913-020-05276-5. | Erchick DJ | BMC Health Serv Res | 2,020 | 2020/05/13 | PMC7212579 | null | 10.1186/s12913-020-05276-5 | oa_comm/txt/all/PMC7212579.txt | 5f1f18b5ab62b9fed67d8ea3cd98e07f | BMC Health Serv Res. 2020 May 11; 20:412 | 2021-06-19 05:27:54 | CC BY | no |
['PMC7212579'] | ['32393349'] | ['CR9', 'CR10', 'CR17', 'CR12', 'CR18', 'CR19', 'CR20', 'CR21', 'CR22', 'CR23', 'CR24', 'CR25', 'CR26', 'CR27', 'CR28', 'CR29', 'CR30', 'CR31', 'CR27', 'CR32', 'CR33', 'CR36', 'CR37', 'CR38', 'CR37', 'CR39'] | Our results demonstrate that auxiliary nurse midwives with minimal training can satisfactorily conduct periodontal examinations at patient homes in rural Nepal. Percent agreement, weighted kappa scores, and intraclass correlation coefficients, with an allowance of ±1 mm, exceeded 99%, 0.7, and 0.9, respectively, indica... | PMC7212579 | Research Article | null | 32,393,349 | Feasibility of training community health workers to conduct periodontal examinations: a validation study in rural Nepal | Erchick DJ, Agrawal NK, Khatry SK, Katz J, LeClerq SC, Rai B, Reynolds MA, Mullany LC. | BMC Health Serv Res. 2020 May 11;20(1):412. doi: 10.1186/s12913-020-05276-5. | Erchick DJ | BMC Health Serv Res | 2,020 | 2020/05/13 | PMC7212579 | null | 10.1186/s12913-020-05276-5 | oa_comm/txt/all/PMC7212579.txt | 5f1f18b5ab62b9fed67d8ea3cd98e07f | BMC Health Serv Res. 2020 May 11; 20:412 | 2021-06-19 05:27:54 | CC BY | no |
['PMC7212579'] | ['32393349'] | ['CR11'] | Our results suggest the potential to shift delivery of certain basic oral health services from dentists and other highly trained professionals to auxiliary nurse midwives or similar CHWs. Policy and programmatic decisions to task CHWs with provision of oral health care should be taken in the context of the multiple fac... | PMC7212579 | Research Article | null | 32,393,349 | Feasibility of training community health workers to conduct periodontal examinations: a validation study in rural Nepal | Erchick DJ, Agrawal NK, Khatry SK, Katz J, LeClerq SC, Rai B, Reynolds MA, Mullany LC. | BMC Health Serv Res. 2020 May 11;20(1):412. doi: 10.1186/s12913-020-05276-5. | Erchick DJ | BMC Health Serv Res | 2,020 | 2020/05/13 | PMC7212579 | null | 10.1186/s12913-020-05276-5 | oa_comm/txt/all/PMC7212579.txt | 5f1f18b5ab62b9fed67d8ea3cd98e07f | BMC Health Serv Res. 2020 May 11; 20:412 | 2021-06-19 05:27:54 | CC BY | no |
['PMC8292936'] | ['34255680'] | ['ref1', 'ref2', 'ref3', 'ref4', 'figure1', 'ref5', 'ref6', 'figure2', 'ref6', 'ref6', 'ref8', 'ref6', 'ref3', 'ref6', 'ref9', 'ref10', 'ref11', 'ref12', 'ref13', 'ref14'] | Arthrogryposis multiplex congenita (AMC) is an umbrella term used to describe more than 400 conditions characterized by congenital joint contractures present in at least two body areas and affecting 1 in 4300-5100 live births [1,2]. Amyoplasia and distal arthrogryposis are the most common types of AMC, representing app... | PMC8292936 | Original Paper; Original Paper | null | 34,255,680 | Using Telerehabilitation to Deliver a Home Exercise Program to Youth With Arthrogryposis: Single Cohort Pilot Study | Gagnon M, Marino Merlo G, Yap R, Collins J, Elfassy C, Sawatzky B, Marsh J, Hamdy R, Veilleux LN, Dahan-Oliel N. | J Med Internet Res. 2021 Jul 6;23(7):e27064. doi: 10.2196/27064. | Gagnon M | J Med Internet Res | 2,021 | 2021/07/13 | PMC8292936 | null | 10.2196/27064 | oa_comm/txt/all/PMC8292936.txt | 6deaa0d6340ab04886302541bec87f41 | J Med Internet Res. 2021 Jul 6; 23(7):e27064 | 2021-09-03 06:53:45 | CC BY | no |
['PMC8292936'] | ['34255680'] | ['ref15', 'ref16', 'ref17', 'ref18'] | Given the rarity, youths with AMC often require specialized care, but many of these individuals live far from subspecialized health care centers. Therefore, clinicians and researchers face challenges in developing adjunct therapies with frequent follow-ups, such as an exercise program. To overcome such challenges, nove... | PMC8292936 | Original Paper; Original Paper | null | 34,255,680 | Using Telerehabilitation to Deliver a Home Exercise Program to Youth With Arthrogryposis: Single Cohort Pilot Study | Gagnon M, Marino Merlo G, Yap R, Collins J, Elfassy C, Sawatzky B, Marsh J, Hamdy R, Veilleux LN, Dahan-Oliel N. | J Med Internet Res. 2021 Jul 6;23(7):e27064. doi: 10.2196/27064. | Gagnon M | J Med Internet Res | 2,021 | 2021/07/13 | PMC8292936 | null | 10.2196/27064 | oa_comm/txt/all/PMC8292936.txt | 6deaa0d6340ab04886302541bec87f41 | J Med Internet Res. 2021 Jul 6; 23(7):e27064 | 2021-09-03 06:53:45 | CC BY | no |
['PMC8292936'] | ['34255680'] | [] | This prospective interventional single-cohort pilot study was conducted between January 2019 and March 2020 at the Shriners Hospitals for Children (SHC)–Canada. The study was approved by the department of medical research at the SHC (CAN1806) in July 2018, and ethics approval was received from the institutional review ... | PMC8292936 | Original Paper; Original Paper | null | 34,255,680 | Using Telerehabilitation to Deliver a Home Exercise Program to Youth With Arthrogryposis: Single Cohort Pilot Study | Gagnon M, Marino Merlo G, Yap R, Collins J, Elfassy C, Sawatzky B, Marsh J, Hamdy R, Veilleux LN, Dahan-Oliel N. | J Med Internet Res. 2021 Jul 6;23(7):e27064. doi: 10.2196/27064. | Gagnon M | J Med Internet Res | 2,021 | 2021/07/13 | PMC8292936 | null | 10.2196/27064 | oa_comm/txt/all/PMC8292936.txt | 6deaa0d6340ab04886302541bec87f41 | J Med Internet Res. 2021 Jul 6; 23(7):e27064 | 2021-09-03 06:53:45 | CC BY | no |
['PMC8292936'] | ['34255680'] | ['ref19'] | To establish the 12-week HEP, an initial assessment was conducted by an occupational therapist and a physical therapist using a videoconferencing platform. This assessment included active ROM measurements of the upper and lower limb joints, an evaluation of overall function (mobility, transfers, and activities of daily... | PMC8292936 | Original Paper; Original Paper | null | 34,255,680 | Using Telerehabilitation to Deliver a Home Exercise Program to Youth With Arthrogryposis: Single Cohort Pilot Study | Gagnon M, Marino Merlo G, Yap R, Collins J, Elfassy C, Sawatzky B, Marsh J, Hamdy R, Veilleux LN, Dahan-Oliel N. | J Med Internet Res. 2021 Jul 6;23(7):e27064. doi: 10.2196/27064. | Gagnon M | J Med Internet Res | 2,021 | 2021/07/13 | PMC8292936 | null | 10.2196/27064 | oa_comm/txt/all/PMC8292936.txt | 6deaa0d6340ab04886302541bec87f41 | J Med Internet Res. 2021 Jul 6; 23(7):e27064 | 2021-09-03 06:53:45 | CC BY | no |
['PMC8292936'] | ['34255680'] | ['app1', 'figure3'] | All information gathered during the initial assessment was used to build an individualized HEP for each participant based on their goals and abilities. The therapists used Physiotec (Physiotec Québec Inc), a software program that easily creates an HEP and provides participants with access to detailed instructions and v... | PMC8292936 | Original Paper; Original Paper | null | 34,255,680 | Using Telerehabilitation to Deliver a Home Exercise Program to Youth With Arthrogryposis: Single Cohort Pilot Study | Gagnon M, Marino Merlo G, Yap R, Collins J, Elfassy C, Sawatzky B, Marsh J, Hamdy R, Veilleux LN, Dahan-Oliel N. | J Med Internet Res. 2021 Jul 6;23(7):e27064. doi: 10.2196/27064. | Gagnon M | J Med Internet Res | 2,021 | 2021/07/13 | PMC8292936 | null | 10.2196/27064 | oa_comm/txt/all/PMC8292936.txt | 6deaa0d6340ab04886302541bec87f41 | J Med Internet Res. 2021 Jul 6; 23(7):e27064 | 2021-09-03 06:53:45 | CC BY | no |
['PMC8292936'] | ['34255680'] | [] | Given that this was a pilot study with a small sample size and a heterogeneous population, nonparametric and descriptive statistics were used.Pvalue corrections for multiple comparisons were not used because of the exploratory purpose of this study. Statistical analyses were performed using IBM SPSS Statistics version ... | PMC8292936 | Original Paper; Original Paper | null | 34,255,680 | Using Telerehabilitation to Deliver a Home Exercise Program to Youth With Arthrogryposis: Single Cohort Pilot Study | Gagnon M, Marino Merlo G, Yap R, Collins J, Elfassy C, Sawatzky B, Marsh J, Hamdy R, Veilleux LN, Dahan-Oliel N. | J Med Internet Res. 2021 Jul 6;23(7):e27064. doi: 10.2196/27064. | Gagnon M | J Med Internet Res | 2,021 | 2021/07/13 | PMC8292936 | null | 10.2196/27064 | oa_comm/txt/all/PMC8292936.txt | 6deaa0d6340ab04886302541bec87f41 | J Med Internet Res. 2021 Jul 6; 23(7):e27064 | 2021-09-03 06:53:45 | CC BY | no |
['PMC8292936'] | ['34255680'] | ['box1', 'ref19', 'app2', 'table1', 'ref29', 'ref30'] | The feasibility was evaluated using different operationalization criteria. These operationalization criteria are listed inTextbox 1and defined in detail in the published protocol for this study [19]. Compliance to the HEP and the telerehabilitation meetings were described using summary statistics and compared with pre-... | PMC8292936 | Original Paper; Original Paper | null | 34,255,680 | Using Telerehabilitation to Deliver a Home Exercise Program to Youth With Arthrogryposis: Single Cohort Pilot Study | Gagnon M, Marino Merlo G, Yap R, Collins J, Elfassy C, Sawatzky B, Marsh J, Hamdy R, Veilleux LN, Dahan-Oliel N. | J Med Internet Res. 2021 Jul 6;23(7):e27064. doi: 10.2196/27064. | Gagnon M | J Med Internet Res | 2,021 | 2021/07/13 | PMC8292936 | null | 10.2196/27064 | oa_comm/txt/all/PMC8292936.txt | 6deaa0d6340ab04886302541bec87f41 | J Med Internet Res. 2021 Jul 6; 23(7):e27064 | 2021-09-03 06:53:45 | CC BY | no |
['PMC8292936'] | ['34255680'] | ['ref20', 'ref21', 'ref23', 'table2'] | The interrater reliability of using a virtual goniometer to measure active ROM has been shown to be feasible when compared with an in-person assessment with a goniometer on 10 healthy adults [20]. However, its reliability has not been assessed in children and adolescents with a musculoskeletal disorder such as AMC. The... | PMC8292936 | Original Paper; Original Paper | null | 34,255,680 | Using Telerehabilitation to Deliver a Home Exercise Program to Youth With Arthrogryposis: Single Cohort Pilot Study | Gagnon M, Marino Merlo G, Yap R, Collins J, Elfassy C, Sawatzky B, Marsh J, Hamdy R, Veilleux LN, Dahan-Oliel N. | J Med Internet Res. 2021 Jul 6;23(7):e27064. doi: 10.2196/27064. | Gagnon M | J Med Internet Res | 2,021 | 2021/07/13 | PMC8292936 | null | 10.2196/27064 | oa_comm/txt/all/PMC8292936.txt | 6deaa0d6340ab04886302541bec87f41 | J Med Internet Res. 2021 Jul 6; 23(7):e27064 | 2021-09-03 06:53:45 | CC BY | no |
['PMC8292936'] | ['34255680'] | ['ref24', 'ref25', 'ref26', 'ref27', 'ref28', 'table3', 'app3', 'app4', 'table4', 'ref31', 'ref32', 'ref33', 'ref34'] | Summary statistics, including the median and 95% CI for continuous variables and counts and proportions for categorical variables, were produced for all variables. As this was a pilot study on a rare disorder, statistical comparisons were produced only for exploratory purposes using a significance (α) level set a prior... | PMC8292936 | Original Paper; Original Paper | null | 34,255,680 | Using Telerehabilitation to Deliver a Home Exercise Program to Youth With Arthrogryposis: Single Cohort Pilot Study | Gagnon M, Marino Merlo G, Yap R, Collins J, Elfassy C, Sawatzky B, Marsh J, Hamdy R, Veilleux LN, Dahan-Oliel N. | J Med Internet Res. 2021 Jul 6;23(7):e27064. doi: 10.2196/27064. | Gagnon M | J Med Internet Res | 2,021 | 2021/07/13 | PMC8292936 | null | 10.2196/27064 | oa_comm/txt/all/PMC8292936.txt | 6deaa0d6340ab04886302541bec87f41 | J Med Internet Res. 2021 Jul 6; 23(7):e27064 | 2021-09-03 06:53:45 | CC BY | no |
['PMC8292936'] | ['34255680'] | ['figure4'] | Of the 114 patients with AMC followed at the SHC–Canada, 26 (22.8%) were eligible to participate and were able to be approached for participation. Of these, 10 individuals consented to the study, and an additional participant not actively followed at the SHC was recruited on social media. A total of 7 participants (5 b... | PMC8292936 | Original Paper; Original Paper | null | 34,255,680 | Using Telerehabilitation to Deliver a Home Exercise Program to Youth With Arthrogryposis: Single Cohort Pilot Study | Gagnon M, Marino Merlo G, Yap R, Collins J, Elfassy C, Sawatzky B, Marsh J, Hamdy R, Veilleux LN, Dahan-Oliel N. | J Med Internet Res. 2021 Jul 6;23(7):e27064. doi: 10.2196/27064. | Gagnon M | J Med Internet Res | 2,021 | 2021/07/13 | PMC8292936 | null | 10.2196/27064 | oa_comm/txt/all/PMC8292936.txt | 6deaa0d6340ab04886302541bec87f41 | J Med Internet Res. 2021 Jul 6; 23(7):e27064 | 2021-09-03 06:53:45 | CC BY | no |
['PMC8292936'] | ['34255680'] | [] | In this study on the use of telerehabilitation to deliver an HEP to youth with AMC, it was found that this approach is feasible and well accepted by participants. The GAS was a feasible measure in this pilot study because it provided the individualization of goals for the youths living with AMC who presented with varyi... | PMC8292936 | Original Paper; Original Paper | null | 34,255,680 | Using Telerehabilitation to Deliver a Home Exercise Program to Youth With Arthrogryposis: Single Cohort Pilot Study | Gagnon M, Marino Merlo G, Yap R, Collins J, Elfassy C, Sawatzky B, Marsh J, Hamdy R, Veilleux LN, Dahan-Oliel N. | J Med Internet Res. 2021 Jul 6;23(7):e27064. doi: 10.2196/27064. | Gagnon M | J Med Internet Res | 2,021 | 2021/07/13 | PMC8292936 | null | 10.2196/27064 | oa_comm/txt/all/PMC8292936.txt | 6deaa0d6340ab04886302541bec87f41 | J Med Internet Res. 2021 Jul 6; 23(7):e27064 | 2021-09-03 06:53:45 | CC BY | no |
['PMC8292936'] | ['34255680'] | [] | Most of the outcomes were standardized, although the HEP was based on individualized goals. The assessment provided did not always correspond to the needs of the participants because they did not provide objective information related to the individualized goals (eg, strength or endurance). For example, joint-specific R... | PMC8292936 | Original Paper; Original Paper | null | 34,255,680 | Using Telerehabilitation to Deliver a Home Exercise Program to Youth With Arthrogryposis: Single Cohort Pilot Study | Gagnon M, Marino Merlo G, Yap R, Collins J, Elfassy C, Sawatzky B, Marsh J, Hamdy R, Veilleux LN, Dahan-Oliel N. | J Med Internet Res. 2021 Jul 6;23(7):e27064. doi: 10.2196/27064. | Gagnon M | J Med Internet Res | 2,021 | 2021/07/13 | PMC8292936 | null | 10.2196/27064 | oa_comm/txt/all/PMC8292936.txt | 6deaa0d6340ab04886302541bec87f41 | J Med Internet Res. 2021 Jul 6; 23(7):e27064 | 2021-09-03 06:53:45 | CC BY | no |
['PMC8292936'] | ['34255680'] | [] | The results of this pilot study suggest that it is feasible to use telerehabilitation to deliver an HEP for youth with AMC having different functional levels, having various goals, and living across different geographical regions. This approach also holds promise regarding the effectiveness of an HEP. Lessons can be le... | PMC8292936 | Original Paper; Original Paper | null | 34,255,680 | Using Telerehabilitation to Deliver a Home Exercise Program to Youth With Arthrogryposis: Single Cohort Pilot Study | Gagnon M, Marino Merlo G, Yap R, Collins J, Elfassy C, Sawatzky B, Marsh J, Hamdy R, Veilleux LN, Dahan-Oliel N. | J Med Internet Res. 2021 Jul 6;23(7):e27064. doi: 10.2196/27064. | Gagnon M | J Med Internet Res | 2,021 | 2021/07/13 | PMC8292936 | null | 10.2196/27064 | oa_comm/txt/all/PMC8292936.txt | 6deaa0d6340ab04886302541bec87f41 | J Med Internet Res. 2021 Jul 6; 23(7):e27064 | 2021-09-03 06:53:45 | CC BY | no |
['PMC9864789'] | ['36674229'] | ['B1-ijerph-20-01477', 'B2-ijerph-20-01477', 'B3-ijerph-20-01477', 'B4-ijerph-20-01477', 'B5-ijerph-20-01477', 'B6-ijerph-20-01477', 'B7-ijerph-20-01477', 'B8-ijerph-20-01477', 'B5-ijerph-20-01477', 'B6-ijerph-20-01477', 'B9-ijerph-20-01477', 'B5-ijerph-20-01477', 'B6-ijerph-20-01477', 'B9-ijerph-20-01477', 'B7-ijerph-... | Cognitive, especially executive, and motor functions, which tend to decline with age, are important in everyday life as the performance of some of the most basic activities requires the simultaneous involvement of both types of these functions [1,2,3]. Performing two activities at the same time (dual-task—DT) can pose ... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | ['B23-ijerph-20-01477', 'ijerph-20-01477-t001'] | Sixty-five participants (16 men and 48 women), over 65 years of age, without neurological, psychiatric, cardiological, or orthopedic diseases/disorders, moving independently, were recruited from senior community centers in Warsaw. Exclusion criteria were a score below 24 points in the Polish version of the Mini-Mental ... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | ['B19-ijerph-20-01477'] | Each examined person, after receiving a telephone notification, was randomly assigned by the project manager to one of four groups: Cognitive Motor Dual-Task Group (CM), Cognitive Task Group (CT), Motor Task Group (MT), or Control Group (C), and obtained a consecutive number from 1 to 20, in accordance with the simple ... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | ['ijerph-20-01477-f001'] | The participants were randomly assigned to one of three groups. The training in the CM group consisted in performing cognitive-motor tasks, the training in the CT group consisted in performing cognitive tasks, and the training in the MT group consisted in performing motor tasks. In the control group, the participants u... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | [] | Two DELL Inspiron (500 series) laptops (DELL LLC, Austin, TX, USA) with a 17.3″ screen and 2 Nintendo Wii Balance Board (Nintendo, Kioto, Japan) posturographic platforms of 30 × 50 cm, integrated for the OpenBCI services, were used in all training sessions. Moreover, an open-source DynamicCognition training on the basi... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | ['B24-ijerph-20-01477'] | The Mini-Mental State Examination [24] (the Polish adaptation and standardization) was used for screening the general cognitive ability. The test examines basic cognitive abilities grouped into 6 areas: orientation in time and place, memorization, attention and counting, recalling, language functions, construction prax... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | [] | Special indicators that measured the interference effect were elaborated for the purpose of this study. The game that was created as part of this study allowed for collecting the orientation and planning time and the number of errors data. | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | [] | In all three training groups, this indicator was related to the same time interval in seconds: from the moment the board was displayed until the first step was performed. However, due to the specificity of the training tasks, it measured slightly different functions in the CM and CT groups than in the MT group. In the ... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | [] | For the participants in the CM and CT groups, this indicator applies to a slightly different construct than in the MT group, due to the specificity of the training tasks. In the CM and CT groups, the number of errors actually indicated the errors made in the planning process, namely incorrect steps. Incorrectly perform... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | ['B25-ijerph-20-01477', 'B26-ijerph-20-01477', 'B27-ijerph-20-01477', 'B26-ijerph-20-01477', 'B28-ijerph-20-01477', 'B26-ijerph-20-01477', 'B26-ijerph-20-01477', 'B26-ijerph-20-01477', 'B29-ijerph-20-01477'] | In order to establish whether the data sets had a normal distribution, the Shapiro–Wilk test was used with the significance levelp< 0.05 [25] corrected for Bonferroni’s multiple comparisonsp= 0.0125 [26]. The test indicated the lack of normal distribution for the obtained results. Therefore, further analysis was carrie... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | ['ijerph-20-01477-f002', 'ijerph-20-01477-t002', 'ijerph-20-01477-t003'] | In the cognitive-motor and cognitive groups, the plot line had similar shapes compared to the single-motor group (Figure 2). The orientation and planning time successively increased to the 5th level and afterwards, it started to decrease. In the MT group, the subjects needed more time at the beginning of the training. ... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | ['ijerph-20-01477-f003', 'ijerph-20-01477-t002', 'ijerph-20-01477-t003'] | The results shown inFigure 3illustrate the similar dynamics of changes after cognitive-motor dual-task and cognitive single-training. The average number of errors increased to the 5th level, and after that, it gradually decreased till the end of the training in both groups. In a single-motor training group, the movemen... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | ['ijerph-20-01477-t004', 'ijerph-20-01477-t005'] | The data inTable 4suggest that the longest time for orientation and planning was required by the participants in the CT group compared to the CM and MT groups. The largest number of errors was made by participants in the CM group compared to the CT and MT groups. The correlation data inTable 5indicate that the orientat... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | [] | The study is of particular importance in the current literature because it shows the mechanism of reduction of the interference effect during dual-task training when compared to the single-task training. The novelty of this study is the analysis of the progress of dual-task and single-task training using two created in... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | ['B13-ijerph-20-01477', 'B14-ijerph-20-01477', 'B15-ijerph-20-01477', 'B16-ijerph-20-01477', 'B17-ijerph-20-01477'] | The obtained results have shown that the training in a dual-task condition was associated with a significantly greater number of errors, but not with a longer task planning time compared to a single-task condition training. The results of this study visibly differ from the classic studies about the Stroop interference ... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | ['B8-ijerph-20-01477', 'B9-ijerph-20-01477', 'B10-ijerph-20-01477', 'B11-ijerph-20-01477', 'B5-ijerph-20-01477', 'B6-ijerph-20-01477'] | There was a decrease in the time needed to plan a path in the mazes among the subjects training in the cognitive-motor, cognitive, and motor groups. From the 6th level of difficulty, an increase of the required time in cognitive-motor and cognitive tasks was obtained. In the MT group, a significant reduction in the tim... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | [] | In comparison to the neuropsychological studies mentioned above, the dual-task training presented in this paper was more cognitively demanding. The interference effect was visible, especially at the beginning of the training and it was present up to the 6th difficulty level, after that it decreased. In the context of f... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | [] | Several limitations of the study should be considered. One of these limitations is the sample blinding method. In the discussed paper, the double-blind standard was not maintained. The project assistants knew to which groups the participants were assigned. Another limitation is the cognitive material (the maze game wit... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC9864789'] | ['36674229'] | [] | Based on the collected data, it can be concluded that dual-task cognitive-motor training is more cognitively demanding than a training to perform single activities, which is visible concerning some of its characteristics. It manifests in a greater number of errors made throughout the training, but it does not extend th... | PMC9864789 | Article | null | 36,674,229 | The Characteristics of the Reduction of Interference Effect during Dual-Task Cognitive-Motor Training Compared to a Single Task Cognitive and Motor Training in Elderly: A Randomized Controlled Trial | Wiśniowska J, Łojek E, Olejnik A, Chabuda A. | Int J Environ Res Public Health. 2023 Jan 13;20(2):1477. doi: 10.3390/ijerph20021477. | Wiśniowska J | Int J Environ Res Public Health | 2,023 | 2023/01/21 | PMC9864789 | null | 10.3390/ijerph20021477 | oa_comm/txt/all/PMC9864789.txt | 4dfc5a4ae36d9ad9ef6ec89d7166eb3a | Int J Environ Res Public Health. 2023 Jan 13; 20(2):1477 | 2023-01-24 23:30:08 | CC BY | no |
['PMC10064342'] | [''] | ['B1', 'B2', 'B3', 'B4', 'B4', 'B5', 'B7', 'B8', 'B2', 'B9', 'B9', 'B10', 'B11'] | The EQ-5D-5L is a widely used preference-based generic instrument that measures today's self-rated health-related quality of life (HRQoL) (1). However, the health state can fluctuate from day to day in various chronic diseases such as Alzheimer's and other related dementia diseases (2,3). People living with dementia (P... | PMC10064342 | Public Health; Study Protocol | null | 37,006,562 | Fluctuations of health states in dementia diseases and their impact on the assessment of health today using the EQ-5D-5L: Protocol of a mixed-methods study | Weber N, Xie F, Kohlmann T, Mohr W, Platen M, Rädke A, Kilimann I, Engel L, Michalowsky B. | Front Public Health. 2023 Mar 16;11:1031978. doi: 10.3389/fpubh.2023.1031978. eCollection 2023. | Weber N | Front Public Health | 2,023 | 2023/04/03 | PMC10064342 | null | 10.3389/fpubh.2023.1031978 | oa_comm/txt/all/PMC10064342.txt | ff444f34bc9f1c8d1f84c594f28332ea | Front Public Health. 2023 Mar 16; 11:1031978 | 2023-04-01 23:19:31 | CC BY | no |
['PMC10064342'] | [''] | [] | This study aims to (i) quantify the occurrence, frequency and intensity of health state fluctuations and underlying health events over 14 days, (ii) identify which HRQoL dimensions may be affected by these fluctuations, and (iii) evaluate if past fluctuations are considered in the assessment of health today using the E... | PMC10064342 | Public Health; Study Protocol | null | 37,006,562 | Fluctuations of health states in dementia diseases and their impact on the assessment of health today using the EQ-5D-5L: Protocol of a mixed-methods study | Weber N, Xie F, Kohlmann T, Mohr W, Platen M, Rädke A, Kilimann I, Engel L, Michalowsky B. | Front Public Health. 2023 Mar 16;11:1031978. doi: 10.3389/fpubh.2023.1031978. eCollection 2023. | Weber N | Front Public Health | 2,023 | 2023/04/03 | PMC10064342 | null | 10.3389/fpubh.2023.1031978 | oa_comm/txt/all/PMC10064342.txt | ff444f34bc9f1c8d1f84c594f28332ea | Front Public Health. 2023 Mar 16; 11:1031978 | 2023-04-01 23:19:31 | CC BY | no |
['PMC10064342'] | [''] | ['T1'] | To understand and explore the impact of health state fluctuations in dementia on the EQ-5D-5L assessment of today's health, this study will be carried out as an explorative, single-group, observational study that combines quantitative and qualitative (mixed) methods over the following four main study phases (seeTable 1... | PMC10064342 | Public Health; Study Protocol | null | 37,006,562 | Fluctuations of health states in dementia diseases and their impact on the assessment of health today using the EQ-5D-5L: Protocol of a mixed-methods study | Weber N, Xie F, Kohlmann T, Mohr W, Platen M, Rädke A, Kilimann I, Engel L, Michalowsky B. | Front Public Health. 2023 Mar 16;11:1031978. doi: 10.3389/fpubh.2023.1031978. eCollection 2023. | Weber N | Front Public Health | 2,023 | 2023/04/03 | PMC10064342 | null | 10.3389/fpubh.2023.1031978 | oa_comm/txt/all/PMC10064342.txt | ff444f34bc9f1c8d1f84c594f28332ea | Front Public Health. 2023 Mar 16; 11:1031978 | 2023-04-01 23:19:31 | CC BY | no |
['PMC10064342'] | [''] | ['B12', 'F1'] | PlwD and their informal caregiver will be recruited in the primary care setting through specifically qualified study nurses who work with general practitioners (GP), neurologists, psychiatrists and memory clinics who are in ongoing collaborations and studies with the German Center for Neurodegenerative Diseases (DZNE) ... | PMC10064342 | Public Health; Study Protocol | null | 37,006,562 | Fluctuations of health states in dementia diseases and their impact on the assessment of health today using the EQ-5D-5L: Protocol of a mixed-methods study | Weber N, Xie F, Kohlmann T, Mohr W, Platen M, Rädke A, Kilimann I, Engel L, Michalowsky B. | Front Public Health. 2023 Mar 16;11:1031978. doi: 10.3389/fpubh.2023.1031978. eCollection 2023. | Weber N | Front Public Health | 2,023 | 2023/04/03 | PMC10064342 | null | 10.3389/fpubh.2023.1031978 | oa_comm/txt/all/PMC10064342.txt | ff444f34bc9f1c8d1f84c594f28332ea | Front Public Health. 2023 Mar 16; 11:1031978 | 2023-04-01 23:19:31 | CC BY | no |
['PMC10064342'] | [''] | ['B9', 'B2'] | The sample size in qualitative research is driven by data saturation. However, there are no standard criteria for calculating the sample size for this type of study. Blome et al. (9) set their sample size in the process guided by information power. We assume the sample size should be large enough to reveal at leastn= 2... | PMC10064342 | Public Health; Study Protocol | null | 37,006,562 | Fluctuations of health states in dementia diseases and their impact on the assessment of health today using the EQ-5D-5L: Protocol of a mixed-methods study | Weber N, Xie F, Kohlmann T, Mohr W, Platen M, Rädke A, Kilimann I, Engel L, Michalowsky B. | Front Public Health. 2023 Mar 16;11:1031978. doi: 10.3389/fpubh.2023.1031978. eCollection 2023. | Weber N | Front Public Health | 2,023 | 2023/04/03 | PMC10064342 | null | 10.3389/fpubh.2023.1031978 | oa_comm/txt/all/PMC10064342.txt | ff444f34bc9f1c8d1f84c594f28332ea | Front Public Health. 2023 Mar 16; 11:1031978 | 2023-04-01 23:19:31 | CC BY | no |
['PMC10064342'] | [''] | ['B13', 'B14', 'B15', 'B16', 'B17', 'B18', 'B19', 'B20', 'B21', 'F2', 'T1'] | At baseline, day seven and day 14, the EQ-5D-5L (13,14) will be administeredviastandardized face-to-face interviews by dementia-specific qualified nurses at patients' or caregivers' homes. Both patients (self-rating) and caregivers (proxy-rating) will be asked to complete the EQ-5D-5L (in separate rooms). Also, patient... | PMC10064342 | Public Health; Study Protocol | null | 37,006,562 | Fluctuations of health states in dementia diseases and their impact on the assessment of health today using the EQ-5D-5L: Protocol of a mixed-methods study | Weber N, Xie F, Kohlmann T, Mohr W, Platen M, Rädke A, Kilimann I, Engel L, Michalowsky B. | Front Public Health. 2023 Mar 16;11:1031978. doi: 10.3389/fpubh.2023.1031978. eCollection 2023. | Weber N | Front Public Health | 2,023 | 2023/04/03 | PMC10064342 | null | 10.3389/fpubh.2023.1031978 | oa_comm/txt/all/PMC10064342.txt | ff444f34bc9f1c8d1f84c594f28332ea | Front Public Health. 2023 Mar 16; 11:1031978 | 2023-04-01 23:19:31 | CC BY | no |
['PMC10064342'] | [''] | ['B13', 'B13', 'B13', 'B14', 'B15', 'B16', 'B17', 'B18', 'B19', 'B20', 'B21'] | The EQ-5D-5L (13) is one of the most used and well-validated generic patient-reported outcome measures that assess patients' HRQoL today. The EQ-5D-5L comprises both the EQ visual analog scale (VAS), ranging from 0 (worst imaginable health) to 100 (best imaginable health) and a descriptive system comprising five dimens... | PMC10064342 | Public Health; Study Protocol | null | 37,006,562 | Fluctuations of health states in dementia diseases and their impact on the assessment of health today using the EQ-5D-5L: Protocol of a mixed-methods study | Weber N, Xie F, Kohlmann T, Mohr W, Platen M, Rädke A, Kilimann I, Engel L, Michalowsky B. | Front Public Health. 2023 Mar 16;11:1031978. doi: 10.3389/fpubh.2023.1031978. eCollection 2023. | Weber N | Front Public Health | 2,023 | 2023/04/03 | PMC10064342 | null | 10.3389/fpubh.2023.1031978 | oa_comm/txt/all/PMC10064342.txt | ff444f34bc9f1c8d1f84c594f28332ea | Front Public Health. 2023 Mar 16; 11:1031978 | 2023-04-01 23:19:31 | CC BY | no |
['PMC10064342'] | [''] | [] | The primary outcomes of this study are (i) the occurrence, frequency and intensity of health state fluctuations documented in the 14-day diary and by using the change in health states from day 1 to day 7 and day 7 to day 14 using the EQ-5D-5L index, the EQ-5D dimensions and the EQ-VAS, (ii) affected HRQoL dimensions, (... | PMC10064342 | Public Health; Study Protocol | null | 37,006,562 | Fluctuations of health states in dementia diseases and their impact on the assessment of health today using the EQ-5D-5L: Protocol of a mixed-methods study | Weber N, Xie F, Kohlmann T, Mohr W, Platen M, Rädke A, Kilimann I, Engel L, Michalowsky B. | Front Public Health. 2023 Mar 16;11:1031978. doi: 10.3389/fpubh.2023.1031978. eCollection 2023. | Weber N | Front Public Health | 2,023 | 2023/04/03 | PMC10064342 | null | 10.3389/fpubh.2023.1031978 | oa_comm/txt/all/PMC10064342.txt | ff444f34bc9f1c8d1f84c594f28332ea | Front Public Health. 2023 Mar 16; 11:1031978 | 2023-04-01 23:19:31 | CC BY | no |
['PMC10064342'] | [''] | ['B24', 'B25'] | Data management will be conducted according to the guidelines and recommendations for ensuring Good Epidemiological Practice (GEP) (24). Study nurses will collect the socio-demographic and clinical data and the EQ-5D-5L using paper-pencil questionnaires during face-to-face visits with the patients and the caregivers. T... | PMC10064342 | Public Health; Study Protocol | null | 37,006,562 | Fluctuations of health states in dementia diseases and their impact on the assessment of health today using the EQ-5D-5L: Protocol of a mixed-methods study | Weber N, Xie F, Kohlmann T, Mohr W, Platen M, Rädke A, Kilimann I, Engel L, Michalowsky B. | Front Public Health. 2023 Mar 16;11:1031978. doi: 10.3389/fpubh.2023.1031978. eCollection 2023. | Weber N | Front Public Health | 2,023 | 2023/04/03 | PMC10064342 | null | 10.3389/fpubh.2023.1031978 | oa_comm/txt/all/PMC10064342.txt | ff444f34bc9f1c8d1f84c594f28332ea | Front Public Health. 2023 Mar 16; 11:1031978 | 2023-04-01 23:19:31 | CC BY | no |
['PMC10064342'] | [''] | ['B26'] | Patient and caregiver characteristics will be demonstrated descriptively. Descriptive statistics will also describe health state fluctuations' occurrence, frequency, and intensity. The occurrence will be operationalized dichotomously: no fluctuations reported vs. at least one fluctuation reported. The frequency will be... | PMC10064342 | Public Health; Study Protocol | null | 37,006,562 | Fluctuations of health states in dementia diseases and their impact on the assessment of health today using the EQ-5D-5L: Protocol of a mixed-methods study | Weber N, Xie F, Kohlmann T, Mohr W, Platen M, Rädke A, Kilimann I, Engel L, Michalowsky B. | Front Public Health. 2023 Mar 16;11:1031978. doi: 10.3389/fpubh.2023.1031978. eCollection 2023. | Weber N | Front Public Health | 2,023 | 2023/04/03 | PMC10064342 | null | 10.3389/fpubh.2023.1031978 | oa_comm/txt/all/PMC10064342.txt | ff444f34bc9f1c8d1f84c594f28332ea | Front Public Health. 2023 Mar 16; 11:1031978 | 2023-04-01 23:19:31 | CC BY | no |
['PMC10064342'] | [''] | ['B27'] | The qualitative interviews will be transcribed, coded using NVivo (version 12, Germany) and analyzed thematically (27). A thematic analysis consists of the following stages: (i) familiarization, (ii) identifying a thematic framework, (iii) indexing, (iv) charting, and (v) mapping and interpretation. This approach is ge... | PMC10064342 | Public Health; Study Protocol | null | 37,006,562 | Fluctuations of health states in dementia diseases and their impact on the assessment of health today using the EQ-5D-5L: Protocol of a mixed-methods study | Weber N, Xie F, Kohlmann T, Mohr W, Platen M, Rädke A, Kilimann I, Engel L, Michalowsky B. | Front Public Health. 2023 Mar 16;11:1031978. doi: 10.3389/fpubh.2023.1031978. eCollection 2023. | Weber N | Front Public Health | 2,023 | 2023/04/03 | PMC10064342 | null | 10.3389/fpubh.2023.1031978 | oa_comm/txt/all/PMC10064342.txt | ff444f34bc9f1c8d1f84c594f28332ea | Front Public Health. 2023 Mar 16; 11:1031978 | 2023-04-01 23:19:31 | CC BY | no |
['PMC10064342'] | [''] | ['B2', 'B9'] | To the best of our knowledge, this will be the first study evaluating the health state fluctuations in dementia diseases using a daily diary to document the change in today's health compared to the day before over 14 days. This study may reveal important insights into the frequency and intensity of health state fluctua... | PMC10064342 | Public Health; Study Protocol | null | 37,006,562 | Fluctuations of health states in dementia diseases and their impact on the assessment of health today using the EQ-5D-5L: Protocol of a mixed-methods study | Weber N, Xie F, Kohlmann T, Mohr W, Platen M, Rädke A, Kilimann I, Engel L, Michalowsky B. | Front Public Health. 2023 Mar 16;11:1031978. doi: 10.3389/fpubh.2023.1031978. eCollection 2023. | Weber N | Front Public Health | 2,023 | 2023/04/03 | PMC10064342 | null | 10.3389/fpubh.2023.1031978 | oa_comm/txt/all/PMC10064342.txt | ff444f34bc9f1c8d1f84c594f28332ea | Front Public Health. 2023 Mar 16; 11:1031978 | 2023-04-01 23:19:31 | CC BY | no |
['PMC10064342'] | [''] | ['B28', 'B29', 'B30'] | Due to the COVID-19 situation in Germany, it has to be noticed that recruitment took place under challenging and changing conditions. Especially aged adults are affected by the COVID-19 diseases and the imposed measures to protect against the spread of the disease (28). These circumstances affect the data assessments a... | PMC10064342 | Public Health; Study Protocol | null | 37,006,562 | Fluctuations of health states in dementia diseases and their impact on the assessment of health today using the EQ-5D-5L: Protocol of a mixed-methods study | Weber N, Xie F, Kohlmann T, Mohr W, Platen M, Rädke A, Kilimann I, Engel L, Michalowsky B. | Front Public Health. 2023 Mar 16;11:1031978. doi: 10.3389/fpubh.2023.1031978. eCollection 2023. | Weber N | Front Public Health | 2,023 | 2023/04/03 | PMC10064342 | null | 10.3389/fpubh.2023.1031978 | oa_comm/txt/all/PMC10064342.txt | ff444f34bc9f1c8d1f84c594f28332ea | Front Public Health. 2023 Mar 16; 11:1031978 | 2023-04-01 23:19:31 | CC BY | no |
['PMC10064342'] | [''] | [] | Protocol Version 08-30-2022: Recruitment for the pilot phase began on the 15thof December 2021 and will probably be completed by the end of January 2022. The roll-out of the final data assessment is planned for February 2022 and is estimated to be finalized by December 2023. | PMC10064342 | Public Health; Study Protocol | null | 37,006,562 | Fluctuations of health states in dementia diseases and their impact on the assessment of health today using the EQ-5D-5L: Protocol of a mixed-methods study | Weber N, Xie F, Kohlmann T, Mohr W, Platen M, Rädke A, Kilimann I, Engel L, Michalowsky B. | Front Public Health. 2023 Mar 16;11:1031978. doi: 10.3389/fpubh.2023.1031978. eCollection 2023. | Weber N | Front Public Health | 2,023 | 2023/04/03 | PMC10064342 | null | 10.3389/fpubh.2023.1031978 | oa_comm/txt/all/PMC10064342.txt | ff444f34bc9f1c8d1f84c594f28332ea | Front Public Health. 2023 Mar 16; 11:1031978 | 2023-04-01 23:19:31 | CC BY | no |
['PMC10064342'] | [''] | [] | The studies involving human participants were reviewed and approved by University Medicine Greifswald (Registry numbers BB128/21 and BB128/21a). The patients/participants provided their written informed consent to participate in this study. | PMC10064342 | Public Health; Study Protocol | null | 37,006,562 | Fluctuations of health states in dementia diseases and their impact on the assessment of health today using the EQ-5D-5L: Protocol of a mixed-methods study | Weber N, Xie F, Kohlmann T, Mohr W, Platen M, Rädke A, Kilimann I, Engel L, Michalowsky B. | Front Public Health. 2023 Mar 16;11:1031978. doi: 10.3389/fpubh.2023.1031978. eCollection 2023. | Weber N | Front Public Health | 2,023 | 2023/04/03 | PMC10064342 | null | 10.3389/fpubh.2023.1031978 | oa_comm/txt/all/PMC10064342.txt | ff444f34bc9f1c8d1f84c594f28332ea | Front Public Health. 2023 Mar 16; 11:1031978 | 2023-04-01 23:19:31 | CC BY | no |
['PMC10064342'] | [''] | [] | The trial was conceptualized by BM, FX, LE, and TK. BM has contributed substantially to the concept of the study and to the draft of the study protocol and will supervise the quantitative analyses. NW is responsible for study processes and trial coordination. LE will be responsible for the qualitative analyses. NW and ... | PMC10064342 | Public Health; Study Protocol | null | 37,006,562 | Fluctuations of health states in dementia diseases and their impact on the assessment of health today using the EQ-5D-5L: Protocol of a mixed-methods study | Weber N, Xie F, Kohlmann T, Mohr W, Platen M, Rädke A, Kilimann I, Engel L, Michalowsky B. | Front Public Health. 2023 Mar 16;11:1031978. doi: 10.3389/fpubh.2023.1031978. eCollection 2023. | Weber N | Front Public Health | 2,023 | 2023/04/03 | PMC10064342 | null | 10.3389/fpubh.2023.1031978 | oa_comm/txt/all/PMC10064342.txt | ff444f34bc9f1c8d1f84c594f28332ea | Front Public Health. 2023 Mar 16; 11:1031978 | 2023-04-01 23:19:31 | CC BY | no |
['PMC6872045'] | ['31751360'] | ['pone.0224961.ref001', 'pone.0224961.ref002', 'pone.0224961.ref003', 'pone.0224961.ref001', 'pone.0224961.ref004', 'pone.0224961.ref005', 'pone.0224961.ref006', 'pone.0224961.ref012', 'pone.0224961.ref013', 'pone.0224961.ref016', 'pone.0224961.ref017', 'pone.0224961.ref018', 'pone.0224961.ref019', 'pone.0224961.ref020... | The estimated prevalence of inflammatory bowel disease (IBD), consisting of Crohn’s Disease (CD), ulcerative colitis (UC) and indeterminate colitis (IC) [1], is 0.2% in the western world [2]. Hence, it is not surprising that physicians are often faced with the diagnostic challenge to differentiate patients with IBD fro... | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | ['pone.0224961.ref019', 'pone.0224961.ref020', 'pone.0224961.g001'] | This study is a part of the prospective diagnostic ALERT trial (VAlidation of an 8-item-questionnaire predictive for a positive caLprotectin tEst andReal-life implemenTation in primary care to reduce diagnostic delay in IBD), consisting of two independent parts A and B, conducted by gastroenterologists (GEs) (A) and ge... | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | [] | Neg = negative; Pos = positive; IBD = Inflammatory bowel disease. | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | [] | Inclusion criteria: Exclusion criteria: | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | ['pone.0224961.t001', 'pone.0224961.ref020', 'pone.0224961.s001'] | CalproQuest is an 8-item IBD-questionnaire consisting of 4 major and 4 minor questions suggestive for IBD (Table 1). The CalproQuest has been shown to be a feasible instrument for the assessment of IBD in PC [20]. The original questionnaire used in our study (German language) can be seen in supporting information (S1 F... | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | [] | Fecal calprotectin levels were measured at the University Hospital Zurich. Specimens from other study centers were sent to the laboratory by mail. The Calprotectin test is called EliA Calprotectin (Thermo Fisher Scientific, Uppsala, Sweden) and uses the FEIA method (fluorescence enzyme immunoassay) on a fully automated... | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | ['pone.0224961.s002'] | Three time intervals of diagnostic delay were assessed retrospectively in a patient questionnaire (S2 Filein German language): Interval 1: Time from first IBD-related symptoms to first consultation with a physician. Interval 2: Time from the first physician visit to referral to GE: Interval 3: Time from first IBD sympt... | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | [] | Primary outcomes: Secondary finding: | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | ['pone.0224961.ref021', 'pone.0224961.ref022'] | A data set was considered complete if a patient completed both the CalproQuest and the Calprotectin test. The sensitivity and specificity calculation of CalproQuest is based on confidence intervals. P<0.05 is considered statistically significant. The sample size was calculated according to Flahault et al. [21]. Assumin... | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | ['pone.0224961.g001', 'pone.0224961.g001', 'pone.0224961.t002', 'pone.0224961.t002'] | Recruitment of GEs started in October 2014 and ended after completion of the necessary dataset in January 2017. Recruitment was undertaken by means of information events as well as mailings and personal contacts of the involved team. Therefore, no actual non-responder list was compiled. The study flow can be appreciate... | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | ['pone.0224961.g002', 'pone.0224961.g003'] | The sensitivity and specificity of CalproQuest for fecal Calprotectin levels ≥ 50 μg/g was 36% and 57% (n = 156). Positive IBD diagnosis was defined as endoscopic diagnosis of active CD or UC or IC (n = 54). The sensitivity and specificity of the CalproQuest for positive IBD diagnosis was 37% and 67% (Fig 2). Fig 3show... | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | [] | TP = true positive, TN = true negative, FP = false positive, FN = false negative, PPV = Positive Predictive Value = TP/(TP+FP), NPV = Negative Predictive Value = TN/(FN+TN), Sensitivity = TP/ (TP+FN), Specificity = TN/(FP+TN), IBD = Inflammatory bowel disease. | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | [] | No association was found between the sensitivity and specifity of the CalproQuest with different Calprotectin levels or with the endoscopy being performed for the first time or as a follow up endoscopy. | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | [] | The mean time from first IBD related symptoms to first consultation with a physician (Interval 1) was 6 months (SD 16.3). The mean reported time from the first physician visit to referral to a gastroenterologist (Interval 2) was 19 months (SD 58.6). The diagnostic delay (= time from first IBD symptoms to IBD diagnosis ... | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | ['pone.0224961.ref020', 'pone.0224961.ref023', 'pone.0224961.ref024', 'pone.0224961.ref025', 'pone.0224961.ref002', 'pone.0224961.ref003', 'pone.0224961.ref019', 'pone.0224961.ref026', 'pone.0224961.ref027', 'pone.0224961.ref028', 'pone.0224961.ref029', 'pone.0224961.ref030', 'pone.0224961.ref027', 'pone.0224961.ref031... | In this prospective diagnostic study, the sensitivity and specificity of CalproQuest, an 8-item IBD-questionnaire consisting of 4 major and 4 minor questions, for fecal Calprotectin levels ≥ 50 μg/g as well as positive IBD diagnosis were poor. The CalproQuest has been shown to be a feasible instrument for the assessmen... | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | ['pone.0224961.ref001', 'pone.0224961.ref004', 'pone.0224961.ref004', 'pone.0224961.ref036', 'pone.0224961.ref037'] | A clear strength of this study is its clinical relevance: as a secondary finding, the diagnostic delay was confirmed to be substantial and hence comparable with previous studies. [1,4] Since this substantial diagnostic delay is clearly associated with an increased risk of morbidity and mortality [4], studies like this ... | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | [] | In this prospective diagnostic study, the sensitivity and specificity of CalproQuest for fecal Calprotectin levels ≥ 50 μg/g as well as positive IBD diagnosis were poor. Additional prospective studies concerning the ideal cut-off values, validity and cost-effectiveness of a combined use with the Calprotectin test in th... | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | [] | Questionnaire for the early detection of inflammatory bowel disease (German language). (DOCX) | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | [] | Questionnaire on patient history for patients suffering from Cohn’s disease or colitis ulcerosa (German language). (DOCX) | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | [] | Ethics consent. (PDF) | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | [] | Transparent Reporting of Evaluations with Nonrandomized Designs. (DOCX) | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | [] | Raw data. (XLSX) | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC6872045'] | ['31751360'] | [] | Consolidated Standards of Reporting Trials. (DOC) | PMC6872045 | Research Article; Medicine and Health Sciences; Gastroenterology and Hepatology; Inflammatory Bowel Disease; Medicine and Health Sciences; Diagnostic Medicine; Medicine and Health Sciences; Surgical and Invasive Medical Procedures; Endoscopy; Medicine and Health Sciences; Health Care; Primary Care; Medicine and Health ... | null | 31,751,360 | Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study | Chmiel C, Senn O, Hasler S, Rosemann T, Rogler G, Zahnd N, Tandjung R, Scherz N, Sulz MC, Vavricka S. | PLoS One. 2019 Nov 21;14(11):e0224961. doi: 10.1371/journal.pone.0224961. eCollection 2019. | Chmiel C | PLoS One | 2,019 | 2019/11/22 | PMC6872045 | null | 10.1371/journal.pone.0224961 | oa_comm/txt/all/PMC6872045.txt | a816c9a999412c726742466187e65ec7 | PLoS One. 2019 Nov 21; 14(11):e0224961 | 2021-06-19 04:42:00 | CC BY | no |
['PMC7359576'] | ['32660609'] | ['CR1', 'CR2', 'CR3', 'CR6', 'CR7', 'CR8', 'CR10', 'Tab1', 'CR13', 'CR15', 'CR12', 'CR16'] | TheHer-2/neugene was first discovered in 1987 and acts as a prognostic indicator of poor survival of breast cancer (BC) [1]. Trastuzumab, a HER2-targeting monoclonal antibody, improves survival for HER2+ BC owing to its prominent anti-HER2 effect [2]. Given that nearly half of HER2+ metastatic breast cancer (MBC) prese... | PMC7359576 | Study Protocol | null | 32,660,609 | Pyrotinib with trastuzumab and aromatase inhibitors as first-line treatment for HER2 positive and hormone receptor positive metastatic or locally advanced breast cancer: study protocol of a randomized controlled trial | Wang C, Lin Y, Zhou Y, Mao F, Zhu H, Guan J, Zhang X, Shen S, Huang X, Chen C, Yao R, Zhao J, Sun Q. | BMC Cancer. 2020 Jul 13;20(1):653. doi: 10.1186/s12885-020-07143-2. | Wang C | BMC Cancer | 2,020 | 2020/07/15 | PMC7359576 | null | 10.1186/s12885-020-07143-2 | oa_comm/txt/all/PMC7359576.txt | 509144d7d25c91edabdf727bcf33b544 | BMC Cancer. 2020 Jul 13; 20:653 | 2021-06-19 05:50:23 | CC BY | no |
['PMC7359576'] | ['32660609'] | ['Fig1'] | The present study is a multicenter, randomized, open-label, phase II study in HR+/HER2- metastatic breast cancer patients who have not received any prior systemic anti-cancer therapy for advanced disease (first-line setting). Eligible patients will be randomized in a 2:1 ratio to either of these groups: pyrotinib+ tras... | PMC7359576 | Study Protocol | null | 32,660,609 | Pyrotinib with trastuzumab and aromatase inhibitors as first-line treatment for HER2 positive and hormone receptor positive metastatic or locally advanced breast cancer: study protocol of a randomized controlled trial | Wang C, Lin Y, Zhou Y, Mao F, Zhu H, Guan J, Zhang X, Shen S, Huang X, Chen C, Yao R, Zhao J, Sun Q. | BMC Cancer. 2020 Jul 13;20(1):653. doi: 10.1186/s12885-020-07143-2. | Wang C | BMC Cancer | 2,020 | 2020/07/15 | PMC7359576 | null | 10.1186/s12885-020-07143-2 | oa_comm/txt/all/PMC7359576.txt | 509144d7d25c91edabdf727bcf33b544 | BMC Cancer. 2020 Jul 13; 20:653 | 2021-06-19 05:50:23 | CC BY | no |
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