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36374874 | 33197716 | 36512043 | Graph Transformer Geometric Learning of Brain Networks Using Multimodal MR Images for Brain Age Estimation. | Accurate brain age prediction with lightweight deep neural networks. | Cardiac MRI in patients with COVID-19 infection. | Brain age is considered as an important biomarker for detecting aging-related diseases such as Alzheimer's Disease (AD). Magnetic resonance imaging (MRI) have been widely investigated with deep neural networks for brain age estimation. However, most existing methods cannot make full use of multimodal MRIs due to the di... | Deep learning has huge potential for accurate disease prediction with neuroimaging data, but the prediction performance is often limited by training-dataset size and computing memory requirements. To address this, we propose a deep convolutional neural network model, Simple Fully Convolutional Network (SFCN), for accur... | COVID-19 infection is a systemic disease with various cardiovascular symptoms and complications. Cardiac MRI with late gadolinium enhancement is the modality of choice for the assessment of myocardial involvement. T1 and T2 mapping can increase diagnostic accuracy and improve further management. Our study aimed to eval... | Graph Transformer Geometric Learning of Brain Networks Using Multimodal MR Images for Brain Age Estimation. Brain age is considered as an important biomarker for detecting aging-related diseases such as Alzheimer's Disease (AD). Magnetic resonance imaging (MRI) have been widely investigated with deep neural networks fo... | Accurate brain age prediction with lightweight deep neural networks. Deep learning has huge potential for accurate disease prediction with neuroimaging data, but the prediction performance is often limited by training-dataset size and computing memory requirements. To address this, we propose a deep convolutional neura... | Cardiac MRI in patients with COVID-19 infection. COVID-19 infection is a systemic disease with various cardiovascular symptoms and complications. Cardiac MRI with late gadolinium enhancement is the modality of choice for the assessment of myocardial involvement. T1 and T2 mapping can increase diagnostic accuracy and im... |
33839631 | 30616875 | 33451816 | Innumerable hemorrhagic brain metastases from a neuroendocrine tumor grade-1 with prolonged natural history. | Surgical treatment of an asymptomatic giant supratentorial cavernous hemangioma. Case report. | Large-Volume Hyperthermia for Safe and Cost-Effective Targeted Drug Delivery Using a Clinical Ultrasound-Guided Focused Ultrasound Device. | Neuroendocrine tumors (NET) are rare tumors with a low incidence of brain metastasis, especially in grade 1 NET. The most common source of brain metastasis is the lung. We present an unusual case of NET grade 1 with multiple hemorrhagic brain metastases.</AbstractText A 46-year-old woman, who initially presented with a... | A case is reported of a 19-year old patient with a supratentorial giant cavernous malformation (GCM). This was an incidental finding in the context of acute head trauma. Brain computed tomography (CT) scan and magnetic resonance imaging (MRI) revealed a giant supratentorial right mass. Surgical excision was performed, ... | Lyso-thermosensitive liposomes (LTSLs) are specifically designed to release chemotherapy agents under conditions of mild hyperthermia. Preclinical studies have indicated that magnetic resonance (MR)-guided focused ultrasound (FUS) systems can generate well-controlled volumetric hyperthermia using real-time thermometry.... | Innumerable hemorrhagic brain metastases from a neuroendocrine tumor grade-1 with prolonged natural history. Neuroendocrine tumors (NET) are rare tumors with a low incidence of brain metastasis, especially in grade 1 NET. The most common source of brain metastasis is the lung. We present an unusual case of NET grade 1 ... | Surgical treatment of an asymptomatic giant supratentorial cavernous hemangioma. Case report. A case is reported of a 19-year old patient with a supratentorial giant cavernous malformation (GCM). This was an incidental finding in the context of acute head trauma. Brain computed tomography (CT) scan and magnetic resonan... | Large-Volume Hyperthermia for Safe and Cost-Effective Targeted Drug Delivery Using a Clinical Ultrasound-Guided Focused Ultrasound Device. Lyso-thermosensitive liposomes (LTSLs) are specifically designed to release chemotherapy agents under conditions of mild hyperthermia. Preclinical studies have indicated that magnet... |
36411785 | 34476184 | 36343534 | Feasibility study of 2D Dixon-Magnetic Resonance Fingerprinting (MRF) of breast cancer. | Repeatability of MR fingerprinting in normal cervix and utility in cervical carcinoma. | Comparison of response properties of the electrically stimulated auditory nerve reported in human listeners and in animal models. | Application of MRF to evaluate the feasibility of 2D Dixon blurring-corrected MRF (2DDb-cMRF) to differentiate breast cancer (BC) from normal fibroglandular tissue (FGT).</AbstractText Prospective study on 14 patients with unilateral BC on 1.5 T system/axial T2w-TSE sequence, 2DDb-cMRF, B1 map, dynamic contrast-en... | Magnetic resonance fingerprinting (MRF) is a fast-imaging acquisition technique that generates quantitative and co-registered parametric maps. The aim of this feasibility study was to evaluate the agreement between MRF and phantom reference values, scan-rescan repeatability of MRF in normal cervix, and its ability to d... | Cochlear implants (CIs) provide acoustic information to implanted patients by electrically stimulating nearby auditory nerve fibers (ANFs) which then transmit the information to higher-level neural structures for further processing and interpretation. Computational models that simulate ANF responses to CI stimuli enabl... | Feasibility study of 2D Dixon-Magnetic Resonance Fingerprinting (MRF) of breast cancer. Application of MRF to evaluate the feasibility of 2D Dixon blurring-corrected MRF (2DDb-cMRF) to differentiate breast cancer (BC) from normal fibroglandular tissue (FGT).</AbstractText Prospective study on 14 patients with unilatera... | Repeatability of MR fingerprinting in normal cervix and utility in cervical carcinoma. Magnetic resonance fingerprinting (MRF) is a fast-imaging acquisition technique that generates quantitative and co-registered parametric maps. The aim of this feasibility study was to evaluate the agreement between MRF and phantom re... | Comparison of response properties of the electrically stimulated auditory nerve reported in human listeners and in animal models. Cochlear implants (CIs) provide acoustic information to implanted patients by electrically stimulating nearby auditory nerve fibers (ANFs) which then transmit the information to higher-level... |
37987558 | 28710580 | 38393608 | Assessment of myocardial injuries in ischaemic and non-ischaemic cardiomyopathies using magnetic resonance T1-rho mapping. | Assessment of acute kidney injury with T1 mapping MRI following solid organ transplantation. | Post-stroke Chinese pure alexia: linguistic features and neuropsychological profiles. | To identify clinical correlates of myocardial T1ρ and to examine how myocardial T1ρ values change under various clinical scenarios.</AbstractText A total of 66 patients (26% female, median age 57 years [Q1-Q3, 44-65 years]) with known structural heart disease and 44 controls (50% female, median age 47 years... | To evaluate T1 mapping as a non-invasive, functional MRI biomarker in patients shortly after solid organ transplantation to detect acute postsurgical kidney damage and to correlate T1 times with renal function.</AbstractText 101 patients within 2 weeks after solid organ transplantation (49 kidney transplantation, ... | Very few cases of Chinese pure alexia have been reported to date. We aim to summarize the linguistic features and neuropsychological profiles of Chinese pure alexia through a case series study.</AbstractText 11 consecutive patients with post-stroke Chinese pure alexia and 11 healthy controls were included. The Aphasia ... | Assessment of myocardial injuries in ischaemic and non-ischaemic cardiomyopathies using magnetic resonance T1-rho mapping. To identify clinical correlates of myocardial T1ρ and to examine how myocardial T1ρ values change under various clinical scenarios.</AbstractText A total of 66 patients (26% female, med... | Assessment of acute kidney injury with T1 mapping MRI following solid organ transplantation. To evaluate T1 mapping as a non-invasive, functional MRI biomarker in patients shortly after solid organ transplantation to detect acute postsurgical kidney damage and to correlate T1 times with renal function.</AbstractText 10... | Post-stroke Chinese pure alexia: linguistic features and neuropsychological profiles. Very few cases of Chinese pure alexia have been reported to date. We aim to summarize the linguistic features and neuropsychological profiles of Chinese pure alexia through a case series study.</AbstractText 11 consecutive patients wi... |
30470988 | 23418584 | 31203463 | Homophone Advantage in Sentence Acceptability Judgment: An Experiment with Japanese Kanji Words and Articulatory Suppression Technique. | The effects of aging on conflict detection. | Skeletal Muscle Wasting and Its Relationship With Osteoarthritis: a Mini-Review of Mechanisms and Current Interventions. | The purpose of this study was to examine the role and nature of phonology in silent reading of Japanese sentences. An experiment was conducted using a Japanese sentence acceptability judgment task. One important finding was that participants more rapidly rejected homophonic sentences in which one two-kanji compound wor... | Several cognitive changes characterize normal aging; one change regards inhibitory processing and includes both conflict monitoring and response suppression. We attempted to segregate these two aspects within a Go/No-go task, investigating three age categories. Accuracy, response times and event-related potentials (ERP... | Osteoarthritis (OA) is a subset of joint disorders resulting in degeneration of synovial joints. This leads to pain, disability and loss of independence. Knee and hip OA are extremely prevalent, and their occurrence increases with ageing. Similarly, loss of muscle mass and function, sarcopenia, occurs during ageing.</A... | Homophone Advantage in Sentence Acceptability Judgment: An Experiment with Japanese Kanji Words and Articulatory Suppression Technique. The purpose of this study was to examine the role and nature of phonology in silent reading of Japanese sentences. An experiment was conducted using a Japanese sentence acceptability j... | The effects of aging on conflict detection. Several cognitive changes characterize normal aging; one change regards inhibitory processing and includes both conflict monitoring and response suppression. We attempted to segregate these two aspects within a Go/No-go task, investigating three age categories. Accuracy, resp... | Skeletal Muscle Wasting and Its Relationship With Osteoarthritis: a Mini-Review of Mechanisms and Current Interventions. Osteoarthritis (OA) is a subset of joint disorders resulting in degeneration of synovial joints. This leads to pain, disability and loss of independence. Knee and hip OA are extremely prevalent, and ... |
35851275 | 24875392 | 35720298 | Meta-analytic evidence that mindfulness training alters resting state default mode network connectivity. | Test-retest reliabilities of resting-state FMRI measurements in human brain functional connectomics: a systems neuroscience perspective. | Upper Gastrointestinal Tract IrAEs: A Case Report About Sintilimab-Induced Acute Erosive Hemorrhagic Gastritis. | This meta-analysis sought to expand upon neurobiological models of mindfulness through investigation of inherent brain network connectivity outcomes, indexed via resting state functional connectivity (rsFC). We conducted a systematic review and meta-analysis of rsFC as an outcome of mindfulness training (MT) relative t... | Resting-state functional magnetic resonance imaging (RFMRI) enables researchers to monitor fluctuations in the spontaneous brain activities of thousands of regions in the human brain simultaneously, representing a popular tool for macro-scale functional connectomics to characterize normal brain function, mind-brain ass... | Immune checkpoint inhibitors (ICIs) have now become the standard therapy for malignancies like non-small cell lung cancer and classical Hodgkin's lymphoma. ICIs are associated with unique immune-related adverse events (irAEs) caused by dysregulated immune activation. Treatment of lower gastrointestinal (GI) tract irAEs... | Meta-analytic evidence that mindfulness training alters resting state default mode network connectivity. This meta-analysis sought to expand upon neurobiological models of mindfulness through investigation of inherent brain network connectivity outcomes, indexed via resting state functional connectivity (rsFC). We cond... | Test-retest reliabilities of resting-state FMRI measurements in human brain functional connectomics: a systems neuroscience perspective. Resting-state functional magnetic resonance imaging (RFMRI) enables researchers to monitor fluctuations in the spontaneous brain activities of thousands of regions in the human brain ... | Upper Gastrointestinal Tract IrAEs: A Case Report About Sintilimab-Induced Acute Erosive Hemorrhagic Gastritis. Immune checkpoint inhibitors (ICIs) have now become the standard therapy for malignancies like non-small cell lung cancer and classical Hodgkin's lymphoma. ICIs are associated with unique immune-related adver... |
29371852 | 23288627 | 28523468 | Devising a Method to Study if Wernicke's Aphasia Patients are Aware That They Do Not Comprehend Language or Speak It Understandably. | Defining language networks from resting-state fMRI for surgical planning--a feasibility study. | Development of a novel radiotherapy motion phantom using a stepper motor driver circuit and evaluation using optical surface scanning. | Wernicke's Aphasia (WA) is characterized by an individual speaking fluent gibberish without the ability to understand anything that is said to them or anything they attempt to read. It is caused by damage to the left posterior temporoparietal cortex, also known as Wernicke's area. An additional intriguing symptom of WA... | Presurgical language mapping for patients with lesions close to language areas is critical to neurosurgical decision-making for preservation of language function. As a clinical noninvasive imaging technique, functional MRI (fMRI) is used to identify language areas by measuring blood-oxygen-level dependent (BOLD) signal... | Recent developments in radiotherapy have focused on the management of patient motion during treatment. Studies have shown that significant gains in treatment quality can be made by 'gating' certain treatments, simultaneously keeping target coverage, and increasing separation to nearby organs at risk (OAR). Motion phant... | Devising a Method to Study if Wernicke's Aphasia Patients are Aware That They Do Not Comprehend Language or Speak It Understandably. Wernicke's Aphasia (WA) is characterized by an individual speaking fluent gibberish without the ability to understand anything that is said to them or anything they attempt to read. It is... | Defining language networks from resting-state fMRI for surgical planning--a feasibility study. Presurgical language mapping for patients with lesions close to language areas is critical to neurosurgical decision-making for preservation of language function. As a clinical noninvasive imaging technique, functional MRI (f... | Development of a novel radiotherapy motion phantom using a stepper motor driver circuit and evaluation using optical surface scanning. Recent developments in radiotherapy have focused on the management of patient motion during treatment. Studies have shown that significant gains in treatment quality can be made by 'gat... |
38845969 | 35304554 | 39253727 | Methodology exploration and reproducibility evaluation of TAI and TSI for quantitative ultrasound assessment of hepatic steatosis. | T1 reduction rate with Gd-EOB-DTPA determines liver function on both 1.5 T and 3 T MRI. | Potential roles of voltage-gated ion channel disruption in Tuberous Sclerosis Complex. | New quantitative ultrasound techniques can be used to quantify hepatic steatosis, including tissue attenuation imaging (TAI), tissue scatter -distribution imaging (TSI), and the hepatorenal index (HRI). However, the measurement norms and the effects of fasting on these measurements remain unclear. The present study per... | Magnetic resonance T1 mapping before and after Gd-EOB-DTPA administration allows quantification of the T1 reduction rate as a non-invasive surrogate marker of liver function. A major limitation of T1 relaxation time measurement is its dependency on MRI field strengths. Since T1 reduction rate is calculated as the relat... | Tuberous Sclerosis Complex (TSC) is a lynchpin disorder, as it results in overactive mammalian target of rapamycin (mTOR) signaling, which has been implicated in a multitude of disease states. TSC is an autosomal dominant disease where 90% of affected individuals develop epilepsy. Epilepsy results from aberrant neurona... | Methodology exploration and reproducibility evaluation of TAI and TSI for quantitative ultrasound assessment of hepatic steatosis. New quantitative ultrasound techniques can be used to quantify hepatic steatosis, including tissue attenuation imaging (TAI), tissue scatter -distribution imaging (TSI), and the hepatorenal... | T1 reduction rate with Gd-EOB-DTPA determines liver function on both 1.5 T and 3 T MRI. Magnetic resonance T1 mapping before and after Gd-EOB-DTPA administration allows quantification of the T1 reduction rate as a non-invasive surrogate marker of liver function. A major limitation of T1 relaxation time measurement is i... | Potential roles of voltage-gated ion channel disruption in Tuberous Sclerosis Complex. Tuberous Sclerosis Complex (TSC) is a lynchpin disorder, as it results in overactive mammalian target of rapamycin (mTOR) signaling, which has been implicated in a multitude of disease states. TSC is an autosomal dominant disease whe... |
32765286 | 35075810 | 31847650 | Acute Low Dose of Trazodone Recovers Glutamate Release Efficiency and mGlu2/3 Autoreceptor Impairments in the Spinal Cord of Rats Suffering From Chronic Sciatic Ligation. | Serotonin receptors in epilepsy: Novel treatment targets? | Spinal cord stimulation modulates complexity of neural activities in patients with disorders of consciousness. | We investigated whether chronic sciatic ligation modifies the glutamate release in spinal cord nerve endings (synaptosomes) as well as the expression and the function of presynaptic release-regulating mGlu2/3 autoreceptors and 5-HT<sub | Despite the availability of over 30 antiseizure medications (ASMs), there is no "one size fits it all," so there is a continuing search for novel ASMs. There are divergent data demonstrating that modulation of distinct serotonin (5-hydroxytryptamine, 5-HT) receptors subtypes could be beneficial in the treatment of epil... | <b | Acute Low Dose of Trazodone Recovers Glutamate Release Efficiency and mGlu2/3 Autoreceptor Impairments in the Spinal Cord of Rats Suffering From Chronic Sciatic Ligation. We investigated whether chronic sciatic ligation modifies the glutamate release in spinal cord nerve endings (synaptosomes) as well as the expression... | Serotonin receptors in epilepsy: Novel treatment targets? Despite the availability of over 30 antiseizure medications (ASMs), there is no "one size fits it all," so there is a continuing search for novel ASMs. There are divergent data demonstrating that modulation of distinct serotonin (5-hydroxytryptamine, 5-HT) recep... | Spinal cord stimulation modulates complexity of neural activities in patients with disorders of consciousness. <b |
40210657 | 28148640 | 39589160 | Children engage neural reward structures for creative musical improvisation. | The role of the hippocampus in navigation is memory. | Copper homeostasis and neurodegenerative diseases. | Children spontaneously engage in creative behaviors. However, little is known about the biological underpinnings of creativity in children. We identified neural substrates associated with musical improvisation in children aged 9-11. Participants played a non-ferromagnetic piano keyboard in a functional magnetic resonan... | There is considerable research on the neurobiological mechanisms within the hippocampal system that support spatial navigation. In this article I review the literature on navigational strategies in humans and animals, observations on hippocampal function in navigation, and studies of hippocampal neural activity in anim... | Copper, one of the most prolific transition metals in the body, is required for normal brain physiological activity and allows various functions to work normally through its range of concentrations. Copper homeostasis is meticulously maintained through a complex network of copper-dependent proteins, including copper tr... | Children engage neural reward structures for creative musical improvisation. Children spontaneously engage in creative behaviors. However, little is known about the biological underpinnings of creativity in children. We identified neural substrates associated with musical improvisation in children aged 9-11. Participan... | The role of the hippocampus in navigation is memory. There is considerable research on the neurobiological mechanisms within the hippocampal system that support spatial navigation. In this article I review the literature on navigational strategies in humans and animals, observations on hippocampal function in navigatio... | Copper homeostasis and neurodegenerative diseases. Copper, one of the most prolific transition metals in the body, is required for normal brain physiological activity and allows various functions to work normally through its range of concentrations. Copper homeostasis is meticulously maintained through a complex networ... |
32525133 | 30287460 | 32576849 | A Novel Metallic Artifact Reduction Technique When Using a Computed Tomography-Guided Percutaneous Metallic Antenna to Ablate Malignant Pulmonary Nodules: A Qualitative and Quantitative Assessment. | Subtraction CTA: An Alternative Imaging Option for the Follow-Up of Flow-Diverter-Treated Aneurysms? | The Contribution of Oculomotor Functions to Rates of Visual Information Processing in Younger and Older Adults. | BACKGROUND Metallic microwave ablation (MWA) antenna-related artifacts are usually created in conventional CT images, and these artifacts can influence the effect of ablation. The aim of this study was to evaluate a new type of metal artifact reduction (MAR+) technique in CT-guided MWA for lung cancer. MATERIAL AND MET... | This was a pilot study to explore the diagnostic accuracy and safety of subtraction CTA combined with a single-energy metal artifact reduction algorithm (SEMAR) compared to DSA for the evaluation of intracranial aneurysm occlusion after flow diverter treatment.</AbstractText We included patients treated with a flow div... | Oculomotor functions are established surrogate measures of visual attention shifting and rate of information processing, however, the temporal characteristics of saccades and fixations have seldom been compared in healthy educated samples of younger and older adults. Thus, the current study aimed to compare duration of... | A Novel Metallic Artifact Reduction Technique When Using a Computed Tomography-Guided Percutaneous Metallic Antenna to Ablate Malignant Pulmonary Nodules: A Qualitative and Quantitative Assessment. BACKGROUND Metallic microwave ablation (MWA) antenna-related artifacts are usually created in conventional CT images, and ... | Subtraction CTA: An Alternative Imaging Option for the Follow-Up of Flow-Diverter-Treated Aneurysms? This was a pilot study to explore the diagnostic accuracy and safety of subtraction CTA combined with a single-energy metal artifact reduction algorithm (SEMAR) compared to DSA for the evaluation of intracranial aneurys... | The Contribution of Oculomotor Functions to Rates of Visual Information Processing in Younger and Older Adults. Oculomotor functions are established surrogate measures of visual attention shifting and rate of information processing, however, the temporal characteristics of saccades and fixations have seldom been compar... |
26257617 | 22928717 | 25689583 | Conditioned place preference successfully established in typically developing children. | Annual Research Review: Resilient functioning in maltreated children--past, present, and future perspectives. | Orally administrated Lactobacillus pentosus var. plantarum C29 ameliorates age-dependent colitis by inhibiting the nuclear factor-kappa B signaling pathway via the regulation of lipopolysaccharide production by gut microbiota. | Affective processing, known to influence attention, motivation, and emotional regulation is poorly understood in young children, especially for those with neurodevelopmental disorders characterized by language impairments. Here we faithfully adapt a well-established animal paradigm used for affective processing, condit... | Through a process of probabilistic epigenesis, child maltreatment progressively contributes to compromised adaptation on a variety of developmental domains central to successful adjustment. These developmental failures pose significant risk for the emergence of psychopathology across the life course. In addition to the... | To evaluate the anti-inflammaging effect of lactic acid bacteria (LAB) on age-dependent inflammation, we first screened and selected a tumor necrosis factor (TNF)-α and reactive oxygen species (ROS)-inhibitory LAB, Lactobacillus pentosus var. plantarum C29, among the LABs isolated from fermented vegetables using ... | Conditioned place preference successfully established in typically developing children. Affective processing, known to influence attention, motivation, and emotional regulation is poorly understood in young children, especially for those with neurodevelopmental disorders characterized by language impairments. Here we f... | Annual Research Review: Resilient functioning in maltreated children--past, present, and future perspectives. Through a process of probabilistic epigenesis, child maltreatment progressively contributes to compromised adaptation on a variety of developmental domains central to successful adjustment. These developmental ... | Orally administrated Lactobacillus pentosus var. plantarum C29 ameliorates age-dependent colitis by inhibiting the nuclear factor-kappa B signaling pathway via the regulation of lipopolysaccharide production by gut microbiota. To evaluate the anti-inflammaging effect of lactic acid bacteria (LAB) on age-dependent infla... |
22373615 | 37192344 | 22356744 | Perspective: Upcoming paradigm shifts for psychiatry in clinical care, research, and education. | Optogenetic stimulation of the superior colliculus suppresses genetic absence seizures. | Growth, photosynthesis and antioxidant responses of endophyte infected and non-infected rice under lead stress conditions. | Psychiatry is facing a crisis fueled by a fragmented and inefficient system of care delivery and a disconnection between the state of research and the state of psychiatry education and practice. Many factors contribute to the current state of psychiatric care. Psychiatry is a shortage specialty, and this will become wo... | While anti-seizure medications are effective for many patients, nearly one-third of individuals have seizures that are refractory to pharmacotherapy. Prior studies using evoked preclinical seizure models have shown that pharmacological activation or excitatory optogenetic stimulation of the deep and intermediate layers... | An endophytic fungus was tested in rice (Oryza sativa L.) exposed to four levels of lead (Pb) stress (0, 50, 100 and 200 μM) to assess effects on plant growth, photosynthesis and antioxidant enzyme activity. Under Pb stress conditions, endophyte-infected seedlings had greater shoot length but lower root length co... | Perspective: Upcoming paradigm shifts for psychiatry in clinical care, research, and education. Psychiatry is facing a crisis fueled by a fragmented and inefficient system of care delivery and a disconnection between the state of research and the state of psychiatry education and practice. Many factors contribute to th... | Optogenetic stimulation of the superior colliculus suppresses genetic absence seizures. While anti-seizure medications are effective for many patients, nearly one-third of individuals have seizures that are refractory to pharmacotherapy. Prior studies using evoked preclinical seizure models have shown that pharmacologi... | Growth, photosynthesis and antioxidant responses of endophyte infected and non-infected rice under lead stress conditions. An endophytic fungus was tested in rice (Oryza sativa L.) exposed to four levels of lead (Pb) stress (0, 50, 100 and 200 μM) to assess effects on plant growth, photosynthesis and antioxidant ... |
31210734 | 28119135 | 31649200 | Dissecting Static and Dynamic Functional Connectivity: Example From the Autism Spectrum. | Relative latency and temporal variability of hemodynamic responses at the human primary visual cortex. | Broadly protective human antibodies that target the active site of influenza virus neuraminidase. | The ability to measure the intrinsic functional architecture of the brain has grown exponentially over the last 2 decades. Measures of intrinsic connectivity within the brain, typically measured using resting-state functional magnetic resonance imaging (MRI), have evolved from primarily "static" approaches, to include ... | The blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) signal is a robust surrogate for local neuronal activity. However, it has been shown to vary substantially across subjects, brain regions, and repetitive measurements. This variability represents a limit to the precision of the BOLD response and the ability ... | Better vaccines against influenza virus are urgently needed to provide broader protection against diverse strains, subtypes, and types. Such efforts are assisted by the identification of novel broadly neutralizing epitopes targeted by protective antibodies. Influenza vaccine development has largely focused on the hemag... | Dissecting Static and Dynamic Functional Connectivity: Example From the Autism Spectrum. The ability to measure the intrinsic functional architecture of the brain has grown exponentially over the last 2 decades. Measures of intrinsic connectivity within the brain, typically measured using resting-state functional magne... | Relative latency and temporal variability of hemodynamic responses at the human primary visual cortex. The blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) signal is a robust surrogate for local neuronal activity. However, it has been shown to vary substantially across subjects, brain regions, and repetitive m... | Broadly protective human antibodies that target the active site of influenza virus neuraminidase. Better vaccines against influenza virus are urgently needed to provide broader protection against diverse strains, subtypes, and types. Such efforts are assisted by the identification of novel broadly neutralizing epitopes... |
37451091 | 30365023 | 36437188 | Higher education level as a protective factor against executive dysfunction in patients with epilepsy in Mataram, Indonesia. | Loneliness and Risk of Dementia. | The chicken and egg problem of grid cells and place cells. | Since the concept of cognitive reserve is applicable in epilepsy-associated cognitive impairment, the role of cognitive reserve components as a protective factor against epilepsy-associated executive dysfunction needs further investigation. This study aimed at investigating the association between cognitive reserve com... | The present study tests whether loneliness is associated with risk of dementia in the largest sample to date and further examines whether the association is independent of social isolation, a related but independent component of social integration, and whether it varies by demographic factors and genetic vulnerability.... | Place cells and grid cells are major building blocks of the hippocampal cognitive map. The prominent forward model postulates that grid-cell modules are generated by a continuous attractor network; that a velocity signal evoked during locomotion moves entorhinal activity bumps; and that place-cell activity constitutes ... | Higher education level as a protective factor against executive dysfunction in patients with epilepsy in Mataram, Indonesia. Since the concept of cognitive reserve is applicable in epilepsy-associated cognitive impairment, the role of cognitive reserve components as a protective factor against epilepsy-associated execu... | Loneliness and Risk of Dementia. The present study tests whether loneliness is associated with risk of dementia in the largest sample to date and further examines whether the association is independent of social isolation, a related but independent component of social integration, and whether it varies by demographic f... | The chicken and egg problem of grid cells and place cells. Place cells and grid cells are major building blocks of the hippocampal cognitive map. The prominent forward model postulates that grid-cell modules are generated by a continuous attractor network; that a velocity signal evoked during locomotion moves entorhina... |
19529979 | 16342275 | 19416835 | Evaluation of utility of asymmetric index for count-based oxygen extraction fraction on dual-tracer autoradiographic method for chronic unilateral brain infarction. | Highly constrained backprojection for time-resolved MRI. | Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways. | For diagnosing patients with ischemic cerebrovascular disease, non-invasive count-based method with (15)O(2) and H (2) (15) O positron-emission tomography (PET) data is widely used to measure asymmetric increases in oxygen extraction fraction (OEF). For shortening study time, we have proposed dual-tracer autoradiograph... | Recent work in k-t BLAST and undersampled projection angiography has emphasized the value of using training data sets obtained during the acquisition of a series of images. These techniques have used iterative algorithms guided by the training set information to reconstruct time frames sampled at well below the Nyquist... | Vitamin deficiency affects up to 50% of the world's population, disproportionately impacting on developing countries where populations endure monotonous, cereal-rich diets. Transgenic plants offer an effective way to increase the vitamin content of staple crops, but thus far it has only been possible to enhance individ... | Evaluation of utility of asymmetric index for count-based oxygen extraction fraction on dual-tracer autoradiographic method for chronic unilateral brain infarction. For diagnosing patients with ischemic cerebrovascular disease, non-invasive count-based method with (15)O(2) and H (2) (15) O positron-emission tomography ... | Highly constrained backprojection for time-resolved MRI. Recent work in k-t BLAST and undersampled projection angiography has emphasized the value of using training data sets obtained during the acquisition of a series of images. These techniques have used iterative algorithms guided by the training set information to ... | Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways. Vitamin deficiency affects up to 50% of the world's population, disproportionately impacting on developing countries where populations endure monotonous, cereal-rich diets. Transgenic p... |
40381124 | 35682902 | 40209050 | Limettin and PD98059 Mitigated Alzheimer's Disease Like Pathology Induced by Streptozotocin in Mouse Model: Role of p-ERK1/2/p-GSK-3β/p-CREB/BDNF Pathway. | Physical Activity Rewires the Human Brain against Neurodegeneration. | What do patients with traumatic brachial plexus injuries need for social and emotional support? A qualitative analysis. | Sporadic Alzheimer's disease (SAD) represents one of the major memory deficits that is characterized by tau hyperphosphorylation and amyloid beta (Aβ) deposition in the brain. Both are considered AD hallmarks which are mediated through neuroinflammation, oxidative stress, and cholinergic circuit interruption. Thi... | Physical activity may offset cognitive decline and dementia, but the molecular mechanisms by which it promotes neuroprotection remain elusive. In the absence of disease-modifying therapies, understanding the molecular effects of physical activity in the brain may be useful for identifying novel targets for disease mana... | Patients with adult traumatic brachial plexus injury (BPI) face numerous challenges, both directly and indirectly related to their physical disability, during their adjustment to life after injury. Our goal was to identify domains of care in which a patient navigator could improve delivery of care for BPI patients as t... | Limettin and PD98059 Mitigated Alzheimer's Disease Like Pathology Induced by Streptozotocin in Mouse Model: Role of p-ERK1/2/p-GSK-3β/p-CREB/BDNF Pathway. Sporadic Alzheimer's disease (SAD) represents one of the major memory deficits that is characterized by tau hyperphosphorylation and amyloid beta (Aβ) depositi... | Physical Activity Rewires the Human Brain against Neurodegeneration. Physical activity may offset cognitive decline and dementia, but the molecular mechanisms by which it promotes neuroprotection remain elusive. In the absence of disease-modifying therapies, understanding the molecular effects of physical activity in t... | What do patients with traumatic brachial plexus injuries need for social and emotional support? A qualitative analysis. Patients with adult traumatic brachial plexus injury (BPI) face numerous challenges, both directly and indirectly related to their physical disability, during their adjustment to life after injury. Ou... |
40289813 | 36801466 | 39755228 | Renal Epithelioid Angiomyolipoma: Prognostic Implications of Targeted Immunohistochemical and Molecular Markers in Conjunction with Clinicopathologic Features. | Determinants of Progression and Mortality in Lymphangioleiomyomatosis. | Explaining neuronal membrane potentials: The Goldman equation vs. Lee's TELC hypothesis. | Epithelioid angiomyolipoma (eAML) is an uncommon subtype of angiomyolipoma, a subset of which can demonstrate malignant behavior. While some studies have proposed histopathologic features predictive of aggressive behavior in eAML, there is limited data on the use of immunohistochemistry (IHC) and/or next-generation seq... | Lymphangioleiomyomatosis is a progressive diffuse cystic lung disease with approximately 85% survival at 10 years. The determinants of disease progression and mortality after the introduction of sirolimus therapy and vascular endothelial growth factor D (VEGF-D) as a biomarker have not been well defined.</Abstract... | In two recent papers (Curr Trends Neurol 17: 83-98, 2023; J Neurophysiol 124: 1029-1044, 2020), James Lee has argued that his Transmembrane Electrostatically-Localized Cations (TELC) hypothesis offers a model of neuron transmembrane potentials that is superior to Hodgkin-Huxley classic cable theory and the Goldman-Hodg... | Renal Epithelioid Angiomyolipoma: Prognostic Implications of Targeted Immunohistochemical and Molecular Markers in Conjunction with Clinicopathologic Features. Epithelioid angiomyolipoma (eAML) is an uncommon subtype of angiomyolipoma, a subset of which can demonstrate malignant behavior. While some studies have propos... | Determinants of Progression and Mortality in Lymphangioleiomyomatosis. Lymphangioleiomyomatosis is a progressive diffuse cystic lung disease with approximately 85% survival at 10 years. The determinants of disease progression and mortality after the introduction of sirolimus therapy and vascular endothelial growth... | Explaining neuronal membrane potentials: The Goldman equation vs. Lee's TELC hypothesis. In two recent papers (Curr Trends Neurol 17: 83-98, 2023; J Neurophysiol 124: 1029-1044, 2020), James Lee has argued that his Transmembrane Electrostatically-Localized Cations (TELC) hypothesis offers a model of neuron transmembran... |
39212585 | 33837273 | 39060234 | Pharmacological Treatment of Tourette Disorder in Children. | Whole-exome sequencing identifies genes associated with Tourette's disorder in multiplex families. | Functional architecture of intracellular oscillations in hippocampal dendrites. | <i | Tourette's Disorder (TD) is a neurodevelopmental disorder (NDD) that affects about 0.7% of the population and is one of the most heritable NDDs. Nevertheless, because of its polygenic nature and genetic heterogeneity, the genetic etiology of TD is not well understood. In this study, we combined the segregation informat... | Fast electrical signaling in dendrites is central to neural computations that support adaptive behaviors. Conventional techniques lack temporal and spatial resolution and the ability to track underlying membrane potential dynamics present across the complex three-dimensional dendritic arbor in vivo. Here, we perform fa... | Pharmacological Treatment of Tourette Disorder in Children. <i | Whole-exome sequencing identifies genes associated with Tourette's disorder in multiplex families. Tourette's Disorder (TD) is a neurodevelopmental disorder (NDD) that affects about 0.7% of the population and is one of the most heritable NDDs. Nevertheless, because of its polygenic nature and genetic heterogeneity, the... | Functional architecture of intracellular oscillations in hippocampal dendrites. Fast electrical signaling in dendrites is central to neural computations that support adaptive behaviors. Conventional techniques lack temporal and spatial resolution and the ability to track underlying membrane potential dynamics present a... |
40662180 | 11699120 | 40394205 | The emotional and motivational costs of poorly delivered academic feedback. | The emotional dog and its rational tail: a social intuitionist approach to moral judgment. | Attention-enhanced StrongSORT for robust vehicle tracking in complex environments. | This study uses psychological reactance theory and self-determination theory to explore whether disrespectful or disorganized feedback affects student motivation and classroom engagement.</AbstractText A sample of 148 undergraduates read one of four vignettes describing professor feedback that varied by tone (respectfu... | Research on moral judgment has been dominated by rationalist models, in which moral judgment is thought to be caused by moral reasoning. The author gives 4 reasons for considering the hypothesis that moral reasoning does not cause moral judgment; rather, moral reasoning is usually a post hoc construction, generated aft... | While multi-object tracking is critical for autonomous driving systems, traditional algorithms exhibit three fundamental limitations in complex scenarios: (1) blurred feature representation under occlusion and re-identification scenarios causing identity switches, (2) insufficient sensitivity to scale-variant targets d... | The emotional and motivational costs of poorly delivered academic feedback. This study uses psychological reactance theory and self-determination theory to explore whether disrespectful or disorganized feedback affects student motivation and classroom engagement.</AbstractText A sample of 148 undergraduates read one of... | The emotional dog and its rational tail: a social intuitionist approach to moral judgment. Research on moral judgment has been dominated by rationalist models, in which moral judgment is thought to be caused by moral reasoning. The author gives 4 reasons for considering the hypothesis that moral reasoning does not caus... | Attention-enhanced StrongSORT for robust vehicle tracking in complex environments. While multi-object tracking is critical for autonomous driving systems, traditional algorithms exhibit three fundamental limitations in complex scenarios: (1) blurred feature representation under occlusion and re-identification scenarios... |
40614156 | 36267854 | 40725956 | Mutualistic Multi-Network Noisy Label Learning (MMNNLL) Method and Its Application to Transdiagnostic Classification of Bipolar Disorder and Schizophrenia. | Effects of exercise on mortality rates of individuals with severe mental illness. | The clinical effective of Baduanjin rehabilitation training on limb motor function, daily life, and quality of life in elderly patients with hemiplegia after stroke. | The subjective nature of diagnosing mental disorders complicates achieving accurate diagnoses. The complex relationship among disorders further exacerbates this issue, particularly in clinical practice where conditions like bipolar disorder (BP) and schizophrenia (SZ) can present similar clinical symptoms and cognitive... | Persons with severe mental illness have a 10-to-20-year shorter life span than the general public. Excess morbidity and mortality in this patient population has been described as a major public health challenge worldwide. Despite robust extant literature on the role of exercise in reducing morbidity and mortality, espe... | This study explores the clinical effects of Baduanjin rehabilitation training on limb motor function, daily living ability, and quality of life in elderly patients with hemiplegia after stroke. Clinical data of 185 elderly patients with hemiplegia after stroke in our hospital from January 2020 to December 2023 were ret... | Mutualistic Multi-Network Noisy Label Learning (MMNNLL) Method and Its Application to Transdiagnostic Classification of Bipolar Disorder and Schizophrenia. The subjective nature of diagnosing mental disorders complicates achieving accurate diagnoses. The complex relationship among disorders further exacerbates this iss... | Effects of exercise on mortality rates of individuals with severe mental illness. Persons with severe mental illness have a 10-to-20-year shorter life span than the general public. Excess morbidity and mortality in this patient population has been described as a major public health challenge worldwide. Despite robust e... | The clinical effective of Baduanjin rehabilitation training on limb motor function, daily life, and quality of life in elderly patients with hemiplegia after stroke. This study explores the clinical effects of Baduanjin rehabilitation training on limb motor function, daily living ability, and quality of life in elderly... |
37150568 | 27918798 | 38004481 | Piloting Peer Support to Decrease Secondary Traumatic Stress, Compassion Fatigue, and Burnout Among Air Medical Crewmembers. | Controlled Interventions to Reduce Burnout in Physicians: A Systematic Review and Meta-analysis. | Study of lncRNAs in Pediatric Neurological Diseases: Methods, Analysis of the State-of-Art and Possible Therapeutic Implications. | The current research was performed to assess professional quality of life; identify factors associated with secondary traumatic stress, burnout, and compassion satisfaction; and evaluate the effectiveness of a peer support pilot intervention among air medical crewmembers.</AbstractText Quantitative research methods wer... | Burnout is prevalent in physicians and can have a negative influence on performance, career continuation, and patient care. Existing evidence does not allow clear recommendations for the management of burnout in physicians.</AbstractText To evaluate the effectiveness of interventions to reduce burnout in physicians and... | Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, and their roles in pediatric neurological diseases are increasingly being explored. This review provides an overview of lncRNA implications in the central nervous system, both in its physiological state and when a pathologi... | Piloting Peer Support to Decrease Secondary Traumatic Stress, Compassion Fatigue, and Burnout Among Air Medical Crewmembers. The current research was performed to assess professional quality of life; identify factors associated with secondary traumatic stress, burnout, and compassion satisfaction; and evaluate the effe... | Controlled Interventions to Reduce Burnout in Physicians: A Systematic Review and Meta-analysis. Burnout is prevalent in physicians and can have a negative influence on performance, career continuation, and patient care. Existing evidence does not allow clear recommendations for the management of burnout in physicians.... | Study of lncRNAs in Pediatric Neurological Diseases: Methods, Analysis of the State-of-Art and Possible Therapeutic Implications. Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, and their roles in pediatric neurological diseases are increasingly being explored. This revi... |
35413649 | 21514250 | 35870168 | Diffusion tensor tractography of the fornix in cerebral amyloid angiopathy, mild cognitive impairment and Alzheimer's disease. | The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. | Interaction of KCNA5, CX43, and CX40 proteins in the atrial muscle of patients with atrial fibrillation. | Cerebral amyloid angiopathy (CAA) is a common neuropathological finding and clinical entity that occurs independently and with co-existent Alzheimer's disease (AD) and small vessel disease. We compared diffusion tensor imaging (DTI) metrics of the fornix, the primary efferent tract of the hippocampus between CAA, AD an... | The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of revising the 1984 criteria for Alzheimer's disease (AD) dementia. The workgroup sought to ensure that the revised criteria would be flexible enough to be used by both general healthcare providers without access to neuro... | The objective of the study was to investigate the expression levels of potassium voltage-gated channel subfamily A member 5 (KCNA5), connexin 43 (Cx43), and connexin 40 (Cx40) in the left atrial appendage of patients with atrial fibrillation (AF) and the interactions between them. We gathered tissue samples from patien... | Diffusion tensor tractography of the fornix in cerebral amyloid angiopathy, mild cognitive impairment and Alzheimer's disease. Cerebral amyloid angiopathy (CAA) is a common neuropathological finding and clinical entity that occurs independently and with co-existent Alzheimer's disease (AD) and small vessel disease. We ... | The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of revising the 1984 criteria ... | Interaction of KCNA5, CX43, and CX40 proteins in the atrial muscle of patients with atrial fibrillation. The objective of the study was to investigate the expression levels of potassium voltage-gated channel subfamily A member 5 (KCNA5), connexin 43 (Cx43), and connexin 40 (Cx40) in the left atrial appendage of patient... |
37798693 | 36875238 | 36520154 | Machine learning applied to fMRI patterns of brain activation in response to mutilation pictures predicts PTSD symptoms. | Perspective taking in the human brain: complementary evidence from neuroimaging studies with media-based naturalistic stimuli and artificial controlled paradigms. | Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice. | The present study aimed to apply multivariate pattern recognition methods to predict posttraumatic stress symptoms from whole-brain activation patterns during two contexts where the aversiveness of unpleasant pictures was manipulated by the presence or absence of safety cues.</AbstractText Trauma-exposed participants w... | Perception and interpretation of various types of events and information in life crucially depend on one's perspective. A specific perspective can be explicitly adopted, for example, <i | Bombesin receptor-activated protein (BRAP) and its homologous protein in mice, which is encoded by <i | Machine learning applied to fMRI patterns of brain activation in response to mutilation pictures predicts PTSD symptoms. The present study aimed to apply multivariate pattern recognition methods to predict posttraumatic stress symptoms from whole-brain activation patterns during two contexts where the aversiveness of u... | Perspective taking in the human brain: complementary evidence from neuroimaging studies with media-based naturalistic stimuli and artificial controlled paradigms. Perception and interpretation of various types of events and information in life crucially depend on one's perspective. A specific perspective can be explici... | Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice. Bombesin receptor-activated protein (BRAP) and its homologous protein in mice, which is encoded by <i |
35560820 | 31272740 | 36384583 | Cardiac involvement in patients recovering from Delta Variant of COVID-19: a prospective multi-parametric MRI study. | Early effects of kidney transplantation on the heart - A cardiac magnetic resonance multi-parametric study. | Access to oral health care for children with fetal alcohol spectrum disorder: a cross-sectional study. | The cardiac injury and sequelae of Delta Variant of coronavirus disease 2019 (COVID-19) remain unknown. This study aimed to evaluate the presence of cardiac involvement in patients recovering from Delta Variant of COVID-19 based on multi-parametric cardiac magnetic resonance imaging (MRI).</AbstractText We prospectivel... | Increased native myocardial T1 times in chronic kidney disease (CKD) may be due to diffuse interstitial myocardial fibrosis (DIF) or due to interstitial edema/inflammation. Concerns relating to nephrogenic systemic fibrosis with gadolinium-based contrast agents (GBCA) limit their use in end-stage kidney disease (ESKD) ... | Individuals with developmental disabilities, including Fetal Alcohol Spectrum Disorder (FASD), often suffer from poorer oral health than the general population as they experience challenges with accessing care. However, few studies have investigated access to oral health care specific to children diagnosed with FASD. T... | Cardiac involvement in patients recovering from Delta Variant of COVID-19: a prospective multi-parametric MRI study. The cardiac injury and sequelae of Delta Variant of coronavirus disease 2019 (COVID-19) remain unknown. This study aimed to evaluate the presence of cardiac involvement in patients recovering from Delta ... | Early effects of kidney transplantation on the heart - A cardiac magnetic resonance multi-parametric study. Increased native myocardial T1 times in chronic kidney disease (CKD) may be due to diffuse interstitial myocardial fibrosis (DIF) or due to interstitial edema/inflammation. Concerns relating to nephrogenic system... | Access to oral health care for children with fetal alcohol spectrum disorder: a cross-sectional study. Individuals with developmental disabilities, including Fetal Alcohol Spectrum Disorder (FASD), often suffer from poorer oral health than the general population as they experience challenges with accessing care. Howeve... |
32979458 | 6493608 | 32006555 | Responses evoked by electrical stimulation of the brainstem reticular formation in the jaw-opening and hypoglossal motor nerves of an arterially perfused rat preparation. | Peculiarities of cerebellar excitation of facial nucleus motoneurons. | HDAC6 inhibitors: Translating genetic and molecular insights into a therapy for axonal CMT. | The interneuronal system in the brainstem reticular formation plays an important role in elaborate muscle coordination during various orofacial motor behaviors. In this study, we examined the distribution in the brainstem reticular formation of the sites that induce monosynaptic motor activity in the mylohyoid (jaw-ope... | Excitatory postsynaptic potentials (EPSPs) of facial nucleus motoneurons evoked by stimulation of the cerebellar nuclei, were studied in anesthetized cats. It is shown that the stimulation of nucleus interpositus and dentatus evoked mono-, oligo- and polysynaptic EPSPs in facial motoneurons. From the experiments with l... | Histone deacetylase 6 (HDAC6) plays a central role in various processes that are key for neuronal survival. In this review, we summarize the current evidence related to disease pathways in the axonal form of Charcot-Marie-Tooth disease (CMT) and highlight the role of HDAC6 in these pathways. We hypothesize that HDAC6 m... | Responses evoked by electrical stimulation of the brainstem reticular formation in the jaw-opening and hypoglossal motor nerves of an arterially perfused rat preparation. The interneuronal system in the brainstem reticular formation plays an important role in elaborate muscle coordination during various orofacial motor... | Peculiarities of cerebellar excitation of facial nucleus motoneurons. Excitatory postsynaptic potentials (EPSPs) of facial nucleus motoneurons evoked by stimulation of the cerebellar nuclei, were studied in anesthetized cats. It is shown that the stimulation of nucleus interpositus and dentatus evoked mono-, oligo- and... | HDAC6 inhibitors: Translating genetic and molecular insights into a therapy for axonal CMT. Histone deacetylase 6 (HDAC6) plays a central role in various processes that are key for neuronal survival. In this review, we summarize the current evidence related to disease pathways in the axonal form of Charcot-Marie-Tooth ... |
21422523 | 17884583 | 21304242 | Disconnection of frontal and parietal areas contributes to impaired attention in very early Alzheimer's disease. | Comparing hemodynamic models with DCM. | Hypoxemia during moderate sedation for gastrointestinal endoscopy: causes and associations. | In Alzheimer's disease (AD), the loss of cerebral connectivity has been evidenced by numerous studies. There is growing evidence of attention related failures already in prodromal stages of AD; however, connectivity changes within attention networks have been rarely reported. Here we focused on effective connectivity o... | The classical model of blood oxygen level-dependent (BOLD) responses by Buxton et al. [Buxton, R.B., Wong, E.C., Frank, L.R., 1998. Dynamics of blood flow and oxygenation changes during brain activation: the Balloon model. Magn. Reson. Med. 39, 855-864] has been very important in providing a biophysically plausible fra... | Although prolonged hypoxemia (henceforth referred to as hypoxemia) is not uncommon during moderate sedation for endoscopy, there are only sparse data regarding its relationship with medications, endoscopic intubations and ventilation patterns. We aimed to study these relationships.</AbstractText 123 patients enrolled i... | Disconnection of frontal and parietal areas contributes to impaired attention in very early Alzheimer's disease. In Alzheimer's disease (AD), the loss of cerebral connectivity has been evidenced by numerous studies. There is growing evidence of attention related failures already in prodromal stages of AD; however, conn... | Comparing hemodynamic models with DCM. The classical model of blood oxygen level-dependent (BOLD) responses by Buxton et al. [Buxton, R.B., Wong, E.C., Frank, L.R., 1998. Dynamics of blood flow and oxygenation changes during brain activation: the Balloon model. Magn. Reson. Med. 39, 855-864] has been very important in ... | Hypoxemia during moderate sedation for gastrointestinal endoscopy: causes and associations. Although prolonged hypoxemia (henceforth referred to as hypoxemia) is not uncommon during moderate sedation for endoscopy, there are only sparse data regarding its relationship with medications, endoscopic intubations and ventil... |
40637595 | 36893722 | 40754650 | Real-world retention of newer ASMs, including lacosamide and brivaracetam as first or second therapies in adult-onset epilepsy. | Real-world, long-term evaluation of the tolerability and therapy retention of Epidiolex® (cannabidiol) in patients with refractory epilepsy. | Evaluating Musculoskeletal Physiotherapist's Self-Perceived Knowledge and Understanding of the Assessment, Diagnosis and Management of Degenerative Cervical Myelopathy: A Cross-Sectional Survey. | Newer antiseizure medications (ASMs), such as lacosamide and brivaracetam, have promising retention in clinical trials but real-world data on their effectiveness when used as first or second treatments is missing. Because newer ASMs are often reserved for severe cases, such knowledge accumulates slowly. We utilized nat... | Epidiolex® (CBD) is FDA-approved for seizures associated with Lennox-Gastaut syndrome (LGS), Dravet syndrome (DS), and tuberous sclerosis complex (TSC). Phase III studies suggest that certain adverse effects (AEs), possibly linked to pharmacokinetic/pharmacodynamic (PK/PD) interactions may be therapy-limiting. We ... | Degenerative cervical myelopathy (DCM) is often inadequately managed, leading to serious long-term consequences for patients. Limited awareness of DCM among healthcare professionals may contribute to this problem.</AbstractText This study aimed to assess UK-based musculoskeletal (MSK) physiotherapists' knowledge and co... | Real-world retention of newer ASMs, including lacosamide and brivaracetam as first or second therapies in adult-onset epilepsy. Newer antiseizure medications (ASMs), such as lacosamide and brivaracetam, have promising retention in clinical trials but real-world data on their effectiveness when used as first or second t... | Real-world, long-term evaluation of the tolerability and therapy retention of Epidiolex® (cannabidiol) in patients with refractory epilepsy. Epidiolex® (CBD) is FDA-approved for seizures associated with Lennox-Gastaut syndrome (LGS), Dravet syndrome (DS), and tuberous sclerosis complex (TSC). Phase III studies sug... | Evaluating Musculoskeletal Physiotherapist's Self-Perceived Knowledge and Understanding of the Assessment, Diagnosis and Management of Degenerative Cervical Myelopathy: A Cross-Sectional Survey. Degenerative cervical myelopathy (DCM) is often inadequately managed, leading to serious long-term consequences for patients.... |
23248590 | 20456660 | 22448217 | Perception-action in children with ASD. | The involvement of emotion recognition in affective theory of mind. | Dynamic 5-HT2C receptor editing in a mouse model of obesity. | How do disturbances to perception and action relate to the deficiencies expressed by children with autism? The ability to predict what is going to happen next is crucial for the construction of all actions and children develop these predictive abilities early in development. Children with autism, however, are deficient... | This study was conducted to explore the relationship between emotion recognition and affective Theory of Mind (ToM). Forty subjects performed a facial emotion recognition and an emotional intention recognition task (affective ToM) in an event-related fMRI study. Conjunction analysis revealed overlapping activation duri... | The central serotonergic signalling system has been shown to play an important role in appetite control and the regulation of food intake. Serotonin exerts its anorectic effects mainly through the 5-HT(1B), 5-HT(2C) and 5-HT(6) receptors and these are therefore receiving increasing attention as principal pharmacotherap... | Perception-action in children with ASD. How do disturbances to perception and action relate to the deficiencies expressed by children with autism? The ability to predict what is going to happen next is crucial for the construction of all actions and children develop these predictive abilities early in development. Chil... | The involvement of emotion recognition in affective theory of mind. This study was conducted to explore the relationship between emotion recognition and affective Theory of Mind (ToM). Forty subjects performed a facial emotion recognition and an emotional intention recognition task (affective ToM) in an event-related f... | Dynamic 5-HT2C receptor editing in a mouse model of obesity. The central serotonergic signalling system has been shown to play an important role in appetite control and the regulation of food intake. Serotonin exerts its anorectic effects mainly through the 5-HT(1B), 5-HT(2C) and 5-HT(6) receptors and these are therefo... |
37422763 | 30291974 | 37473791 | Distinct ventral stream and prefrontal cortex representational dynamics during sustained conscious visual perception. | Mapping the human brain's cortical-subcortical functional network organization. | Effects of inhaled corticosteroids on brain volumetry, depression and anxiety-like behaviors in a rat model of asthma. | Instances of sustained stationary sensory input are ubiquitous. However, previous work focused almost exclusively on transient onset responses. This presents a critical challenge for neural theories of consciousness, which should account for the full temporal extent of experience. To address this question, we use intra... | Understanding complex systems such as the human brain requires characterization of the system's architecture across multiple levels of organization - from neurons, to local circuits, to brain regions, and ultimately large-scale brain networks. Here we focus on characterizing the human brain's large-scale network organi... | Brain functional deficits have been reported in asthma patients which can result in behavioral disorders like depression and anxiety. These deficits may be associated with factors like resistance to treatment, incorrect self-evaluation, and inadequate self-control. However, changes in the brain volume in allergic asthm... | Distinct ventral stream and prefrontal cortex representational dynamics during sustained conscious visual perception. Instances of sustained stationary sensory input are ubiquitous. However, previous work focused almost exclusively on transient onset responses. This presents a critical challenge for neural theories of ... | Mapping the human brain's cortical-subcortical functional network organization. Understanding complex systems such as the human brain requires characterization of the system's architecture across multiple levels of organization - from neurons, to local circuits, to brain regions, and ultimately large-scale brain networ... | Effects of inhaled corticosteroids on brain volumetry, depression and anxiety-like behaviors in a rat model of asthma. Brain functional deficits have been reported in asthma patients which can result in behavioral disorders like depression and anxiety. These deficits may be associated with factors like resistance to tr... |
39483919 | 38155477 | 39145525 | More similarity than difference: comparison of within- and between-sex variance in early adolescent brain structure. | Association between structural brain MRI abnormalities and epilepsy in older adults. | Astrocytic centrin-2 expression in entorhinal cortex correlates with Alzheimer's disease severity. | Adolescent neuroimaging studies of sex differences in the human brain predominantly examine mean differences between males and females. This focus on between-groups differences without probing relative distributions and similarities may contribute to both conflation and overestimation of sex differences and sexual dimo... | To determine the association between brain MRI abnormalities and incident epilepsy in older adults.</AbstractText Men and women (ages 45-64 years) from the Atherosclerosis Risk in Communities study were followed up from 1987 to 2018 with brain MRI performed between 2011 and 2013. We identified cases of incident ... | Astrogliosis is a condition shared by acute and chronic neurological diseases and includes morphological, proteomic, and functional rearrangements of astroglia. In Alzheimer's disease (AD), reactive astrocytes frame amyloid deposits and exhibit structural changes associated with the overexpression of specific proteins,... | More similarity than difference: comparison of within- and between-sex variance in early adolescent brain structure. Adolescent neuroimaging studies of sex differences in the human brain predominantly examine mean differences between males and females. This focus on between-groups differences without probing relative d... | Association between structural brain MRI abnormalities and epilepsy in older adults. To determine the association between brain MRI abnormalities and incident epilepsy in older adults.</AbstractText Men and women (ages 45-64 years) from the Atherosclerosis Risk in Communities study were followed up from 1987 to ... | Astrocytic centrin-2 expression in entorhinal cortex correlates with Alzheimer's disease severity. Astrogliosis is a condition shared by acute and chronic neurological diseases and includes morphological, proteomic, and functional rearrangements of astroglia. In Alzheimer's disease (AD), reactive astrocytes frame amylo... |
40657200 | 28426964 | 40304470 | Anti-Inflammatory Treatment of Subarachnoid Hemorrhage by Self-Assembled Silymarin Nanoparticles. | iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. | The impact of temperature and insect-specific viruses on the transmission of alphaviruses by Aedes japonicus japonicus. | Subarachnoid hemorrhage (SAH) is a common hemorrhagic cerebrovascular disease with high disability rate and high mortality. Early brain injury (EBI) is the main cause of high mortality and delayed neurological dysfunction in patients with SAH. Neuroinflammation is the important pathological processes of EBI.We prepared... | Microglia play critical roles in brain development, homeostasis, and neurological disorders. Here, we report that human microglial-like cells (iMGLs) can be differentiated from iPSCs to study their function in neurological diseases, like Alzheimer's disease (AD). We find that iMGLs develop in vitro similarly to mi... | Arthropod-borne virus (arbovirus) infections are increasing globally, and invasive mosquito species are spreading. Since the end of the last century, <i The spread of invasive mosquito species like <i | Anti-Inflammatory Treatment of Subarachnoid Hemorrhage by Self-Assembled Silymarin Nanoparticles. Subarachnoid hemorrhage (SAH) is a common hemorrhagic cerebrovascular disease with high disability rate and high mortality. Early brain injury (EBI) is the main cause of high mortality and delayed neurological dysfunction ... | iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Microglia play critical roles in brain development, homeostasis, and neurological disorders. Here, we report that human microglial-like cells (iMGLs) can be differentiated from iPSCs to study their function in neurological diseases, like Alzheimer'... | The impact of temperature and insect-specific viruses on the transmission of alphaviruses by Aedes japonicus japonicus. Arthropod-borne virus (arbovirus) infections are increasing globally, and invasive mosquito species are spreading. Since the end of the last century, <i The spread of invasive mosquito species like <i |
39855672 | 27636179 | 40469522 | Efficacy and safety of mechanical thrombectomy in patients with acute ischemic stroke and left ventricular assist device: review of the literature and meta-analysis. | Image-guided endoscopic surgery for spontaneous supratentorial intracerebral hematoma. | ggClusterNet 2: An R package for microbial co-occurrence networks and associated indicator correlation patterns. | Left ventricular assist devices (LVADs) are used as definitive therapy or as a bridge to heart transplant in patients with advanced heart failure. Thromboembolic complications such as acute ischemic stroke (AIS) are common among patients with LVAD support. This study aims to evaluate the current evidence on the efficac... | OBJECTIVE Endoscopic removal of intracerebral hematomas is becoming increasingly common, but there is no standard technique. The authors explored the use of a simple image-guided endoscopic method for removal of spontaneous supratentorial hematomas. METHODS Virtual reality technology based on a hospital picture archivi... | Since its initial release in 2022, <i | Efficacy and safety of mechanical thrombectomy in patients with acute ischemic stroke and left ventricular assist device: review of the literature and meta-analysis. Left ventricular assist devices (LVADs) are used as definitive therapy or as a bridge to heart transplant in patients with advanced heart failure. Thrombo... | Image-guided endoscopic surgery for spontaneous supratentorial intracerebral hematoma. OBJECTIVE Endoscopic removal of intracerebral hematomas is becoming increasingly common, but there is no standard technique. The authors explored the use of a simple image-guided endoscopic method for removal of spontaneous supratent... | ggClusterNet 2: An R package for microbial co-occurrence networks and associated indicator correlation patterns. Since its initial release in 2022, <i |
38007285 | 28501096 | 38537123 | Clinical Interpretation of Intravoxel Incoherent Motion Perfusion Imaging in the Brain. | Combined diffusion-weighted imaging and dynamic contrast-enhanced MRI for differentiating radiologically indeterminate malignant from benign orbital masses. | Excitatory cerebellar transcranial direct current stimulation boosts the leverage of prior knowledge for predicting actions. | Intravoxel incoherent motion (IVIM) perfusion imaging extracts information on blood motion in biological tissue from diffusion-weighted MR images. The method is attractive from a clinical stand point, because it measures in essence local quantitative perfusion, without intravenous contrast injection. Currently, the cli... | To evaluate the performance of the combination of diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) for differentiating radiologically indeterminate malignant from benign orbital masses.</AbstractText Sixty-five patients with orbital masses (36 benign and 29 malignant) underwe... | The cerebellum causally supports social processing by generating internal models of social events based on statistical learning of behavioral regularities. However, whether the cerebellum is only involved in forming or also in using internal models for the prediction of forthcoming actions is still unclear. We used cer... | Clinical Interpretation of Intravoxel Incoherent Motion Perfusion Imaging in the Brain. Intravoxel incoherent motion (IVIM) perfusion imaging extracts information on blood motion in biological tissue from diffusion-weighted MR images. The method is attractive from a clinical stand point, because it measures in essence ... | Combined diffusion-weighted imaging and dynamic contrast-enhanced MRI for differentiating radiologically indeterminate malignant from benign orbital masses. To evaluate the performance of the combination of diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) for differentiating ... | Excitatory cerebellar transcranial direct current stimulation boosts the leverage of prior knowledge for predicting actions. The cerebellum causally supports social processing by generating internal models of social events based on statistical learning of behavioral regularities. However, whether the cerebellum is only... |
38165369 | 21890158 | 39128571 | Characteristics and Prognosis of Tumor-Related Epilepsy During Tumor Evolution in Patients With IDH Wild-Type Glioblastoma. | Brain tumor epilepsy: a reappraisal and six remaining issues to be debated. | Alpha-synuclein fine-tunes neuronal response to pro-inflammatory cytokines. | Tumor-related epilepsy is a well-known symptom of glioblastoma. However, the particular characteristics of epileptic seizures related to glioblastoma, <i We performed an observational, retrospective single-center study at one tertiary referral neuro-oncology surgical center (2000-2020). We included adult patients treat... | Epilepsy associated with brain tumors presents with specific features deserving medical attention. Although commonly reported in patients with brain tumor, either as revealing mode or as a remote complication, limited knowledge is available regarding their epidemiology, clinical evolution, surgical outcome, physiopatho... | Pro-inflammatory cytokines are emerging as neuroinflammatory mediators in Parkinson's disease (PD) due to their ability to act through neuronal cytokine receptors. Critical questions persist regarding the role of cytokines in neuronal dysfunction and their contribution to PD pathology. Specifically, the potential syner... | Characteristics and Prognosis of Tumor-Related Epilepsy During Tumor Evolution in Patients With IDH Wild-Type Glioblastoma. Tumor-related epilepsy is a well-known symptom of glioblastoma. However, the particular characteristics of epileptic seizures related to glioblastoma, <i We performed an observational, retrospecti... | Brain tumor epilepsy: a reappraisal and six remaining issues to be debated. Epilepsy associated with brain tumors presents with specific features deserving medical attention. Although commonly reported in patients with brain tumor, either as revealing mode or as a remote complication, limited knowledge is available reg... | Alpha-synuclein fine-tunes neuronal response to pro-inflammatory cytokines. Pro-inflammatory cytokines are emerging as neuroinflammatory mediators in Parkinson's disease (PD) due to their ability to act through neuronal cytokine receptors. Critical questions persist regarding the role of cytokines in neuronal dysfuncti... |
40546462 | 38112964 | 40263772 | Gut Microbiota as a Key Modulator of Chronic Disease: Implications for Diabetes, Autoimmunity, and Cancer. | Neuroprotective effect of curcumin against experimental autoimmune encephalomyelitis-induced cognitive and physical impairments in mice: an insight into the role of the AMPK/SIRT1 pathway. | Reduced Cacna1c Expression Produces Anhedonic Reactions to Palatable Sucrose in Rats: No Interactions With Juvenile or Adult Stress. | The gut microbiota (GM) represents an intricate, dynamic, and complex ecosystem. It plays a key role in health and disease. The GM interacts with the host and modulates various physiological functions, including metabolism, immune regulation, and neurological function. This narrative review comprehensive... | Multiple sclerosis (MS) is an incurable chronic neurodegenerative disease where autoimmunity, oxidative stress, and neuroinflammation collaboration predispose myelin sheath destruction. Interestingly, curcumin, a natural polyphenol, showed a neuroprotective effect in numerous neurodegenerative diseases, including MS. N... | Genetic variation in CACNA1C, which encodes the alpha-1 subunit of Ca<sub | Gut Microbiota as a Key Modulator of Chronic Disease: Implications for Diabetes, Autoimmunity, and Cancer. The gut microbiota (GM) represents an intricate, dynamic, and complex ecosystem. It plays a key role in health and disease. The GM interacts with the host and modulates various physiological functio... | Neuroprotective effect of curcumin against experimental autoimmune encephalomyelitis-induced cognitive and physical impairments in mice: an insight into the role of the AMPK/SIRT1 pathway. Multiple sclerosis (MS) is an incurable chronic neurodegenerative disease where autoimmunity, oxidative stress, and neuroinflammati... | Reduced Cacna1c Expression Produces Anhedonic Reactions to Palatable Sucrose in Rats: No Interactions With Juvenile or Adult Stress. Genetic variation in CACNA1C, which encodes the alpha-1 subunit of Ca<sub |
35821766 | 33613274 | 33502474 | Impairments in the Default Mode and Executive Networks in Methamphetamine Users During Short-Term Abstinence. | Alterations in Dynamic Functional Connectivity in Individuals With Subjective Cognitive Decline. | Humanized Transgenic Mice Are Resistant to Chronic Wasting Disease Prions From Norwegian Reindeer and Moose. | Methamphetamine use may cause severe neurotoxicity and cognitive impairment, leading to addiction, overdose, and high rates of relapse. However, few studies have systematically focused on functional impairments detected by neuroimaging in methamphetamine abstainers (MAs) during short-term abstinence. This study aimed t... | <b | Chronic wasting disease (CWD) is the transmissible spongiform encephalopathy or prion disease affecting cervids. In 2016, the first cases of CWD were reported in Europe in Norwegian wild reindeer and moose. The origin and zoonotic potential of these new prion isolates remain unknown. In this study to investigate zoonot... | Impairments in the Default Mode and Executive Networks in Methamphetamine Users During Short-Term Abstinence. Methamphetamine use may cause severe neurotoxicity and cognitive impairment, leading to addiction, overdose, and high rates of relapse. However, few studies have systematically focused on functional impairments... | Alterations in Dynamic Functional Connectivity in Individuals With Subjective Cognitive Decline. <b | Humanized Transgenic Mice Are Resistant to Chronic Wasting Disease Prions From Norwegian Reindeer and Moose. Chronic wasting disease (CWD) is the transmissible spongiform encephalopathy or prion disease affecting cervids. In 2016, the first cases of CWD were reported in Europe in Norwegian wild reindeer and moose. The ... |
39926461 | 37237103 | 40341990 | Immunoexcitoxicity as the possible major pathophysiology behind multiple sclerosis and other autoimmune disorders. | The impact of the human thalamus on brain-wide information processing. | Navigating the risks and rewards of scavenging in multipredator, human-impacted landscapes. | Autoimmune disorders are destructive processes considered to be an attack on "self " antigens by the immune system CD-+4 T-cells that are directed toward antigens, in the case of multiple sclerosis (MS), particularly myelin antigens. Yet, there is growing evidence that the major destructive events in MS, as well as oth... | The thalamus is a small, bilateral structure in the diencephalon that integrates signals from many areas of the CNS. This critical anatomical position allows the thalamus to influence whole-brain activity and adaptive behaviour. However, traditional research paradigms have struggled to attribute specific functions to t... | Large carnivores can influence smaller scavengers through both positive and negative interactions (e.g., carrion provisioning and intraguild killing) and ultimately shape scavenging efficiency. However, we know little about this trade-off in anthropogenic landscapes where humans kill carnivores and provide carrion subs... | Immunoexcitoxicity as the possible major pathophysiology behind multiple sclerosis and other autoimmune disorders. Autoimmune disorders are destructive processes considered to be an attack on "self " antigens by the immune system CD-+4 T-cells that are directed toward antigens, in the case of multiple sclerosis (MS), p... | The impact of the human thalamus on brain-wide information processing. The thalamus is a small, bilateral structure in the diencephalon that integrates signals from many areas of the CNS. This critical anatomical position allows the thalamus to influence whole-brain activity and adaptive behaviour. However, traditional... | Navigating the risks and rewards of scavenging in multipredator, human-impacted landscapes. Large carnivores can influence smaller scavengers through both positive and negative interactions (e.g., carrion provisioning and intraguild killing) and ultimately shape scavenging efficiency. However, we know little about this... |
37933745 | 28642283 | 38473363 | Progressive Brain Atrophy in Multiple System Atrophy: A Longitudinal, Multicenter, Magnetic Resonance Imaging Study. | Selective Inhibition of Trigeminovascular Neurons by Fremanezumab: A Humanized Monoclonal Anti-CGRP Antibody. | Pixelwise Gradient Model with GAN for Virtual Contrast Enhancement in MRI Imaging. | To determine the rates of brain atrophy progression in vivo in patients with multiple system atrophy (MSA).</AbstractText Surrogate biomarkers of disease progression are a major unmet need in MSA. Small-scale longitudinal studies in patients with MSA using magnetic resonance imaging (MRI) to assess progression of brain... | A large body of evidence supports an important role for calcitonin gene-related peptide (CGRP) in migraine pathophysiology. This evidence gave rise to a global effort to develop a new generation of therapeutics that inhibit the interaction of CGRP with its receptor in migraineurs. Recently, a new class of such drugs, h... | <b | Progressive Brain Atrophy in Multiple System Atrophy: A Longitudinal, Multicenter, Magnetic Resonance Imaging Study. To determine the rates of brain atrophy progression in vivo in patients with multiple system atrophy (MSA).</AbstractText Surrogate biomarkers of disease progression are a major unmet need in MSA. Small-... | Selective Inhibition of Trigeminovascular Neurons by Fremanezumab: A Humanized Monoclonal Anti-CGRP Antibody. A large body of evidence supports an important role for calcitonin gene-related peptide (CGRP) in migraine pathophysiology. This evidence gave rise to a global effort to develop a new generation of therapeutics... | Pixelwise Gradient Model with GAN for Virtual Contrast Enhancement in MRI Imaging. <b |
21820518 | 16306418 | 22822175 | Network modulation during complex syntactic processing. | Separate face and body selectivity on the fusiform gyrus. | Transdiagnostic treatment of bipolar disorder and comorbid anxiety with the unified protocol: a clinical replication series. | Complex sentence processing is supported by a left-lateralized neural network including inferior frontal cortex and posterior superior temporal cortex. This study investigates the pattern of connectivity and information flow within this network. We used fMRI BOLD data derived from 12 healthy participants reported in an... | Recent reports of a high response to bodies in the fusiform face area (FFA) challenge the idea that the FFA is exclusively selective for face stimuli. We examined this claim by conducting a functional magnetic resonance imaging experiment at both standard (3.125 x 3.125 x 4.0 mm) and high resolution (1.4 x 1.4 x 2.0 mm... | Bipolar disorder (BD) is a chronic, debilitating disorder with recurrent manic and depressive episodes. More than 75% of bipolar patients have a current or lifetime diagnosis of a comorbid anxiety disorder. Comorbid anxiety in BD is associated with greater illness severity, greater functional impairment, and poorer ill... | Network modulation during complex syntactic processing. Complex sentence processing is supported by a left-lateralized neural network including inferior frontal cortex and posterior superior temporal cortex. This study investigates the pattern of connectivity and information flow within this network. We used fMRI BOLD ... | Separate face and body selectivity on the fusiform gyrus. Recent reports of a high response to bodies in the fusiform face area (FFA) challenge the idea that the FFA is exclusively selective for face stimuli. We examined this claim by conducting a functional magnetic resonance imaging experiment at both standard (3.125... | Transdiagnostic treatment of bipolar disorder and comorbid anxiety with the unified protocol: a clinical replication series. Bipolar disorder (BD) is a chronic, debilitating disorder with recurrent manic and depressive episodes. More than 75% of bipolar patients have a current or lifetime diagnosis of a comorbid anxiet... |
39378968 | 26500511 | 40728555 | Maternal heart exhibits metabolic and redox adaptations post-uncomplicated pregnancy. | Neurogenesis paradoxically decreases both pattern separation and memory interference. | Molecular Characterization of Carbapenemase Genes in Carbapenem-Resistant Klebsiella pneumoniae Isolates. | Pregnancy may be a challenging period for the maternal systems and has been regarded as a stress test, as imperceptible/mild dysfunctions eventually present may be exacerbated during this period. The cardiovascular system is no exception, and several morphological and functional adaptations accompanying pregnancy have ... | The hippocampus has been the focus of memory research for decades. While the functional role of this structure is not fully understood, it is widely recognized as being vital for rapid yet accurate encoding and retrieval of associative memories. Since the discovery of adult hippocampal neurogenesis in the dentate gyrus... | Carbapenemase genes play important role in the formation and dissemination of carbapenem-resistant Klebsiella pneumoniae (CRKP). The aim of this study was to investigate the distribution of carbapenemase genes in clinical CRKP isolates. Eighty-three clinical CRKPs were collected and antimicrobial susceptibility testing... | Maternal heart exhibits metabolic and redox adaptations post-uncomplicated pregnancy. Pregnancy may be a challenging period for the maternal systems and has been regarded as a stress test, as imperceptible/mild dysfunctions eventually present may be exacerbated during this period. The cardiovascular system is no except... | Neurogenesis paradoxically decreases both pattern separation and memory interference. The hippocampus has been the focus of memory research for decades. While the functional role of this structure is not fully understood, it is widely recognized as being vital for rapid yet accurate encoding and retrieval of associativ... | Molecular Characterization of Carbapenemase Genes in Carbapenem-Resistant Klebsiella pneumoniae Isolates. Carbapenemase genes play important role in the formation and dissemination of carbapenem-resistant Klebsiella pneumoniae (CRKP). The aim of this study was to investigate the distribution of carbapenemase genes in c... |
40603121 | 38967126 | 40788849 | [Analysis of rapeutic effect of musculoskeletal ultrasound-guided acupuncture for the treatment of myofascial pain syndrome after rotator cuff suture under shoulder arthroscopy]. | The molecular biology of NF2/Merlin on tumorigenesis and development. | The ghost of infections past: Accounting for heterogeneity in individual infection history improves accuracy in epidemic forecasting. | To compare clinical efficacy of musculoskeletal ultrasound-guided acupuncture treatment and radiation extracorporeal shock wave therapy in myofascial pain syndrome after rotator cuff suture under shoulder arthroscopy.</AbstractText From June 2021 to April 2022, 75 patients with myofascial pain syndrome after rotator cu... | The neurofibromatosis type 2 (NF2) gene, known for encoding the tumor suppressor protein Merlin, is central to the study of tumorigenesis and associated cellular processes. This review comprehensively examines the multifaceted role of NF2/Merlin, detailing its structural characteristics, functional diversity, and invol... | Variation in infection history is an important but often underappreciated driver of individual variability in responses to infections. Such individual heterogeneity in immune responses, stemming from variable previous exposure to pathogens, subsequently influences epidemiological outcomes. By comparing research on inna... | [Analysis of rapeutic effect of musculoskeletal ultrasound-guided acupuncture for the treatment of myofascial pain syndrome after rotator cuff suture under shoulder arthroscopy]. To compare clinical efficacy of musculoskeletal ultrasound-guided acupuncture treatment and radiation extracorporeal shock wave therapy in my... | The molecular biology of NF2/Merlin on tumorigenesis and development. The neurofibromatosis type 2 (NF2) gene, known for encoding the tumor suppressor protein Merlin, is central to the study of tumorigenesis and associated cellular processes. This review comprehensively examines the multifaceted role of NF2/Merlin, det... | The ghost of infections past: Accounting for heterogeneity in individual infection history improves accuracy in epidemic forecasting. Variation in infection history is an important but often underappreciated driver of individual variability in responses to infections. Such individual heterogeneity in immune responses, ... |
37334197 | 16389308 | 36454259 | C. elegans ATG-5 mutants associated with ataxia. | The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies. | Diagnostic accuracy of ultrasound-based multimodal radiomics modeling for fibrosis detection in chronic kidney disease. | Intercellular cleaning via autophagy is crucial for maintaining cellular homeostasis, and impaired autophagy has been associated with the accumulation of protein aggregates that can contribute to neurological diseases. Specifically, the loss-of-function mutation in the human autophagy-related gene 5 (ATG5) at E122D has... | Huntington's disease (HD) is a genetic neurodegenerative disorder. Since identification of the disease-causing gene in 1993, a number of genetically modified animal models of HD have been generated. The first transgenic mouse models, R6/1 and R6/2 lines, were established 8 years ago. The R6/2 mice have been the best ch... | To predict kidney fibrosis in patients with chronic kidney disease using radiomics of two-dimensional ultrasound (B-mode) and Sound Touch Elastography (STE) images in combination with clinical features.</AbstractText The Mindray Resona 7 ultrasonic diagnostic apparatus with SC5-1U convex array probe (bandwidth frequenc... | C. elegans ATG-5 mutants associated with ataxia. Intercellular cleaning via autophagy is crucial for maintaining cellular homeostasis, and impaired autophagy has been associated with the accumulation of protein aggregates that can contribute to neurological diseases. Specifically, the loss-of-function mutation in the h... | The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies. Huntington's disease (HD) is a genetic neurodegenerative disorder. Since identification of the disease-causing gene in 1993, a number of genetically modified animal models of HD have been generated. Th... | Diagnostic accuracy of ultrasound-based multimodal radiomics modeling for fibrosis detection in chronic kidney disease. To predict kidney fibrosis in patients with chronic kidney disease using radiomics of two-dimensional ultrasound (B-mode) and Sound Touch Elastography (STE) images in combination with clinical feature... |
38781152 | 30104762 | 37812733 | Brain health index as a predictor of possible vascular dementia in the Mexican health and aging study 2012-2015. | Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. | Computed tomography dose index determination in dose modulation prospectively involving the third-generation iterative reconstruction and noise index. | To determine the burden of disease among subjects at risk of developing stroke or dementia, brain health indexes (BHI) tend to rely on anatomical features. Recent definitions emphasize the need of a broader perspective that encompasses cardiovascular risk factors (CVRFS) and lifestyle components which can be considered... | A key public health need is to identify individuals at high risk for a given disease to enable enhanced screening or preventive therapies. Because most common diseases have a genetic component, one important approach is to stratify individuals based on inherited DNA variation<sup | Optimizing CT protocols is challenging in the presence of automatic dose modulation because the CT dose index (CTDI<sub Dose modulation data were collected on a GE Revolution 256-slice scanner utilizing a Mercury phantom and selections of the noise index (NI) from 8 to 17, the third generation iterative reconstruction ... | Brain health index as a predictor of possible vascular dementia in the Mexican health and aging study 2012-2015. To determine the burden of disease among subjects at risk of developing stroke or dementia, brain health indexes (BHI) tend to rely on anatomical features. Recent definitions emphasize the need of a broader ... | Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. A key public health need is to identify individuals at high risk for a given disease to enable enhanced screening or preventive therapies. Because most common diseases have a genetic component, one importa... | Computed tomography dose index determination in dose modulation prospectively involving the third-generation iterative reconstruction and noise index. Optimizing CT protocols is challenging in the presence of automatic dose modulation because the CT dose index (CTDI<sub Dose modulation data were collected on a GE Revol... |
39276720 | 30620687 | 37647984 | Prominent loss of striatal dopamine transporter binding in frontotemporal lobar degeneration with the MAPT N279K mutation present as early as at prodromal stage without parkinsonism. | Spinal cord involvement in Lewy body-related α-synucleinopathies. | Insights into plant salt stress signaling and tolerance. | Our research found out, from <sup | <b | Soil salinization is an essential environmental stressor, threatening agricultural yield and ecological security worldwide. Saline soils accumulate excessive soluble salts which are detrimental to most plants by limiting plant growth and productivity. It is of great necessity for plants to efficiently deal with the adv... | Prominent loss of striatal dopamine transporter binding in frontotemporal lobar degeneration with the MAPT N279K mutation present as early as at prodromal stage without parkinsonism. Our research found out, from <sup | Spinal cord involvement in Lewy body-related α-synucleinopathies. <b | Insights into plant salt stress signaling and tolerance. Soil salinization is an essential environmental stressor, threatening agricultural yield and ecological security worldwide. Saline soils accumulate excessive soluble salts which are detrimental to most plants by limiting plant growth and productivity. It is of gr... |
40411939 | 39371035 | 40693647 | Epidemiology of adult brain tumors in the Philippine General Hospital from 2018 to 2022: Initial steps to a national brain tumor registry in a lower-middle income country. | CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2017-2021. | Efficacy of Low-Dose BoNT-A Acupoint Injections in Managing Headache, Vertigo, and Allodynia in Vestibular Migraine. | In the Philippines, there is a lack of epidemiological data on brain tumors due to the absence of a national registry. To bridge this gap, our team has set out to review histopathologically-confirmed brain tumor cases from 2018 to 2022 at the largest neurosurgical center in the country. 766 brain tumor cases were ident... | The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control and Prevention and the National Cancer Institute, is the largest population-based registry focused exclusively on primary brain and other central nervous system (CNS) tumors in the United States (US) an... | BACKGROUND: This study examines low-dose botulinum toxin at acupuncture points for its effects on vestibular symptoms, headaches, depression, anxiety, and stress in vestibular migraine patients. METHODS: This prospective study included patients with vestibular migraine per Barany Society criteria. Fifty units of Onabot... | Epidemiology of adult brain tumors in the Philippine General Hospital from 2018 to 2022: Initial steps to a national brain tumor registry in a lower-middle income country. In the Philippines, there is a lack of epidemiological data on brain tumors due to the absence of a national registry. To bridge this gap, our team ... | CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2017-2021. The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control and Prevention and the National Cancer Institute, is the largest population-... | Efficacy of Low-Dose BoNT-A Acupoint Injections in Managing Headache, Vertigo, and Allodynia in Vestibular Migraine. BACKGROUND: This study examines low-dose botulinum toxin at acupuncture points for its effects on vestibular symptoms, headaches, depression, anxiety, and stress in vestibular migraine patients. METHODS:... |
36924807 | 30394561 | 37718484 | Characterization of motion dependent magnetic field inhomogeneity for DWI in the kidneys. | Evaluating corrections for Eddy-currents and other EPI distortions in diffusion MRI: methodology and a dataset for benchmarking. | Treatment resistance in schizophrenia: a meta-analysis of prevalence and correlates. | Diffusion-weighted imaging (DWI) of the abdomen has increased dramatically for both research and clinical purposes. Motion and static field inhomogeneity related challenges limit image quality of abdominopelvic imaging with the most conventional echo-planar imaging (EPI) pulse sequence. While reversed phase encoded ima... | To propose a methodology for assessment of algorithms that correct distortions due to motion, eddy-currents, and echo planar imaging in diffusion weighted images (DWIs).</AbstractText The proposed method evaluates correction performance by measuring variability across datasets of the same object acquired with images ha... | To determine the prevalence and correlates of treatment-resistant schizophrenia (TRS) through a systematic review and meta-analysis.</AbstractText Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria, an electronic search was performed in PubMed and Embase through May 17, 2022.... | Characterization of motion dependent magnetic field inhomogeneity for DWI in the kidneys. Diffusion-weighted imaging (DWI) of the abdomen has increased dramatically for both research and clinical purposes. Motion and static field inhomogeneity related challenges limit image quality of abdominopelvic imaging with the mo... | Evaluating corrections for Eddy-currents and other EPI distortions in diffusion MRI: methodology and a dataset for benchmarking. To propose a methodology for assessment of algorithms that correct distortions due to motion, eddy-currents, and echo planar imaging in diffusion weighted images (DWIs).</AbstractText The pro... | Treatment resistance in schizophrenia: a meta-analysis of prevalence and correlates. To determine the prevalence and correlates of treatment-resistant schizophrenia (TRS) through a systematic review and meta-analysis.</AbstractText Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) cr... |
24319599 | 19395674 | 24075840 | Making memories: the development of long-term visual knowledge in children with visual agnosia. | The ITP syndrome: pathogenic and clinical diversity. | Solid-state NMR investigations of peptide-lipid interactions of the transmembrane domain of a plant-derived protein, Hcf106. | There are few reports about the effects of perinatal acquired brain lesions on the development of visual perception. These studies demonstrate nonseverely impaired visual-spatial abilities and preserved visual memory. Longitudinal data analyzing the effects of compromised perceptions on long-term visual knowledge in ag... | Immune thrombocytopenia (ITP) is mediated by platelet autoantibodies that accelerate platelet destruction and inhibit their production. Most cases are considered idiopathic, whereas others are secondary to coexisting conditions. Insights from secondary forms suggest that the proclivity to develop platelet-reactive anti... | The chloroplast twin arginine translocation system transports highly folded precursor proteins across the thylakoid using the protonmotive force as its only energy source. Hcf106 and another thylakoid protein, cpTatC compose the precursor receptor complex. Hcf106 is predicted to contain a single amino terminal transmem... | Making memories: the development of long-term visual knowledge in children with visual agnosia. There are few reports about the effects of perinatal acquired brain lesions on the development of visual perception. These studies demonstrate nonseverely impaired visual-spatial abilities and preserved visual memory. Longit... | The ITP syndrome: pathogenic and clinical diversity. Immune thrombocytopenia (ITP) is mediated by platelet autoantibodies that accelerate platelet destruction and inhibit their production. Most cases are considered idiopathic, whereas others are secondary to coexisting conditions. Insights from secondary forms suggest ... | Solid-state NMR investigations of peptide-lipid interactions of the transmembrane domain of a plant-derived protein, Hcf106. The chloroplast twin arginine translocation system transports highly folded precursor proteins across the thylakoid using the protonmotive force as its only energy source. Hcf106 and another thyl... |
16834334 | 11234013 | 16360124 | Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1. | A sodium-channel mutation causes isolated cardiac conduction disease. | Desensitization of 5-HT2A receptor function by chronic administration of selective serotonin reuptake inhibitors. | Kir2.1 channels play a key role in maintaining the correct resting potential in eukaryotic cells. Recently, specific amino acid mutations in the Kir2.1 inwardly rectifying potassium channel have been found to cause Andersen's Syndrome in humans. Here, we have characterized individual Andersen's Syndrome mutants R218Q, ... | Cardiac conduction disorders slow the heart rhythm and cause disability in millions of people worldwide. Inherited mutations in SCN5A, the gene encoding the human cardiac sodium (Na+) channel, have been associated with rapid heart rhythms that occur suddenly and are life-threatening; however, a chief function of the Na... | We have previously shown that chronic treatment with selective serotonin reuptake inhibitors (SSRIs), fluvoxamine and paroxetine, attenuated m-chlorophenylpiperazine (mCPP)-induced hypolocomotion in rats. The effect of these SSRIs on the response to mCPP is thought to be caused by the desensitization of 5-HT2C receptor... | Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1. Kir2.1 channels play a key role in maintaining the correct resting potential in eukaryotic cells. Recently, specific amino acid mutations in the Kir2.1 inwardly rectifying potassium channel have been found to cause ... | A sodium-channel mutation causes isolated cardiac conduction disease. Cardiac conduction disorders slow the heart rhythm and cause disability in millions of people worldwide. Inherited mutations in SCN5A, the gene encoding the human cardiac sodium (Na+) channel, have been associated with rapid heart rhythms that occur ... | Desensitization of 5-HT2A receptor function by chronic administration of selective serotonin reuptake inhibitors. We have previously shown that chronic treatment with selective serotonin reuptake inhibitors (SSRIs), fluvoxamine and paroxetine, attenuated m-chlorophenylpiperazine (mCPP)-induced hypolocomotion in rats. T... |
25345488 | 25934706 | 26471732 | Prolactin and natural killer cells: evaluating the neuroendocrine-immune axis in women with primary infertility and recurrent spontaneous abortion. | 60 YEARS OF NEUROENDOCRINOLOGY: Redefining neuroendocrinology: stress, sex and cognitive and emotional regulation. | Mg(2+) shifts ligand-mediated folding of a riboswitch from induced-fit to conformational selection. | An association between serum prolactin (PRL) and peripheral blood natural killer (NK) cells has been described in healthy women. We explored for the first time the PRL response to the thyrotrophin-releasing hormone (TRH) test and the association between PRL and NK cells in women with reproductive failure.</AbstractText... | The discovery of steroid hormone receptors in brain regions that mediate every aspect of brain function has broadened the definition of 'neuroendocrinology' to include the reciprocal communication between the brain and the body via hormonal and neural pathways. The brain is the central organ of stress and adaptation to... | Bacterial riboswitches couple small-molecule ligand binding to RNA conformational changes that widely regulate gene expression, rendering them potential targets for antibiotic intervention. Despite structural insights, the ligand-mediated folding mechanisms of riboswitches are still poorly understood. Using single-mole... | Prolactin and natural killer cells: evaluating the neuroendocrine-immune axis in women with primary infertility and recurrent spontaneous abortion. An association between serum prolactin (PRL) and peripheral blood natural killer (NK) cells has been described in healthy women. We explored for the first time the PRL resp... | 60 YEARS OF NEUROENDOCRINOLOGY: Redefining neuroendocrinology: stress, sex and cognitive and emotional regulation. The discovery of steroid hormone receptors in brain regions that mediate every aspect of brain function has broadened the definition of 'neuroendocrinology' to include the reciprocal communication between ... | Mg(2+) shifts ligand-mediated folding of a riboswitch from induced-fit to conformational selection. Bacterial riboswitches couple small-molecule ligand binding to RNA conformational changes that widely regulate gene expression, rendering them potential targets for antibiotic intervention. Despite structural insights, t... |
38952000 | 33547610 | 39771868 | Syndromic Surveillance Tracks COVID-19 Cases in University and County Settings: Retrospective Observational Study. | Meteorological factors, COVID-19 cases, and deaths in top 10 most affected countries: an econometric investigation. | Dynamic Emotion Recognition and Expression Imitation in Neurotypical Adults and Their Associations with Autistic Traits. | Syndromic surveillance represents a potentially inexpensive supplement to test-based COVID-19 surveillance. By strengthening surveillance of COVID-19-like illness (CLI), targeted and rapid interventions can be facilitated that prevent COVID-19 outbreaks without primary reliance on testing.</AbstractText This study aims... | This paper examines the nexus between the Covid-19 confirmed cases, deaths, meteorological factors, including an air pollutant among the world's top 10 infected countries, from 1 February 2020 through 30 June 2020, using advanced econometric techniques to address heterogeneity across the nations. The findings of the st... | Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction and communication. While many studies suggest that individuals with ASD struggle with emotion processing, the association between emotion processing and autistic traits in non-clinical populations is still un... | Syndromic Surveillance Tracks COVID-19 Cases in University and County Settings: Retrospective Observational Study. Syndromic surveillance represents a potentially inexpensive supplement to test-based COVID-19 surveillance. By strengthening surveillance of COVID-19-like illness (CLI), targeted and rapid interventions ca... | Meteorological factors, COVID-19 cases, and deaths in top 10 most affected countries: an econometric investigation. This paper examines the nexus between the Covid-19 confirmed cases, deaths, meteorological factors, including an air pollutant among the world's top 10 infected countries, from 1 February 2020 through 30 ... | Dynamic Emotion Recognition and Expression Imitation in Neurotypical Adults and Their Associations with Autistic Traits. Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction and communication. While many studies suggest that individuals with ASD struggle with e... |
37182185 | 37995674 | 36732369 | Case Report: A novel heterozygous nonsense mutation in KRIT1 cause hereditary cerebral cavernous malformation. | Hemorrhagic Outcome of Brainstem Cavernous Malformations following Radiosurgery: Dose-Response Relationship. | Lead exposure in childhood and historical land use: a geostatistical analysis of soil lead concentrations in South Philadelphia parks. | Cerebral cavernous malformation (CCM) is a vascular malformation of the central nervous system and mainly characterized by enlarged capillary cavities without intervening brain parenchyma. Genetic studies have identified three disease-causing genes (<i | This study aimed to assess the impact of gamma knife radiosurgery on brainstem cavernous malformations (CMs).</AbstractText A total of 85 patients (35 females; median age 41.0 years) who underwent gamma knife radiosurgery for brainstem CMs at our institute between 2006 and 2015 were enrolled in a prospective clinical o... | Elevated soil lead (Pb) concentrations in public parks and outdoor spaces continue to have a significant impact on the public health of urban communities. This study evaluated the geospatial and statistical relationships between soil Pb concentrations, the urban environment, and child blood lead levels (BLLs) in the ne... | Case Report: A novel heterozygous nonsense mutation in KRIT1 cause hereditary cerebral cavernous malformation. Cerebral cavernous malformation (CCM) is a vascular malformation of the central nervous system and mainly characterized by enlarged capillary cavities without intervening brain parenchyma. Genetic studies have... | Hemorrhagic Outcome of Brainstem Cavernous Malformations following Radiosurgery: Dose-Response Relationship. This study aimed to assess the impact of gamma knife radiosurgery on brainstem cavernous malformations (CMs).</AbstractText A total of 85 patients (35 females; median age 41.0 years) who underwent gamma knife ra... | Lead exposure in childhood and historical land use: a geostatistical analysis of soil lead concentrations in South Philadelphia parks. Elevated soil lead (Pb) concentrations in public parks and outdoor spaces continue to have a significant impact on the public health of urban communities. This study evaluated the geosp... |
33314281 | 31332874 | 34494108 | Diffusion-PEPTIDE: Distortion- and blurring-free diffusion imaging with self-navigated motion-correction and relaxometry capabilities. | Data Quality and Optimal Background Correction Order of Respiratory-Gated k-Space Segmented Spoiled Gradient Echo (SGRE) and Echo Planar Imaging (EPI)-Based 4D Flow MRI. | Higher Ultra-Processed Food Consumption Is Associated with Increased Risk of Incident Coronary Artery Disease in the Atherosclerosis Risk in Communities Study. | To implement the time-resolved relaxometry PEPTIDE technique into a diffusion acquisition to provide self-navigated, distortion- and blurring-free diffusion imaging that is robust to motion, while simultaneously providing T<sub The PEPTIDE readout was implemented into a spin-echo diffusion acquisition, enabling reconst... | A reduction in scan time of 4D Flow MRI would facilitate clinical application. A recent study indicates that echo-planar imaging (EPI) 4D Flow MRI allows for a reduction in scan time and better data quality than the recommended k-space segmented spoiled gradient echo (SGRE) sequence. It was argued that the poor data qu... | Higher ultra-processed food intake has been linked with several cardiometabolic and cardiovascular diseases. However, prospective evidence from US populations remains scarce.</AbstractText To test the hypothesis that higher intake of ultra-processed foods is associated with higher risk of coronary artery disease.</Abst... | Diffusion-PEPTIDE: Distortion- and blurring-free diffusion imaging with self-navigated motion-correction and relaxometry capabilities. To implement the time-resolved relaxometry PEPTIDE technique into a diffusion acquisition to provide self-navigated, distortion- and blurring-free diffusion imaging that is robust to mo... | Data Quality and Optimal Background Correction Order of Respiratory-Gated k-Space Segmented Spoiled Gradient Echo (SGRE) and Echo Planar Imaging (EPI)-Based 4D Flow MRI. A reduction in scan time of 4D Flow MRI would facilitate clinical application. A recent study indicates that echo-planar imaging (EPI) 4D Flow MRI all... | Higher Ultra-Processed Food Consumption Is Associated with Increased Risk of Incident Coronary Artery Disease in the Atherosclerosis Risk in Communities Study. Higher ultra-processed food intake has been linked with several cardiometabolic and cardiovascular diseases. However, prospective evidence from US populations r... |
30382380 | 28981354 | 31905629 | Impact of sodium (18)F-fluoride PET/CT, (18)F-fluorocholine PET/CT and whole-body diffusion-weighted MRI on the management of patients with prostate cancer suspicious for metastasis: a prospective multicentre study. | Whole-Body MRI: Current Applications in Oncology. | A Low-Power CMOS Wireless Acoustic Sensing Platform for Remote Surveillance Applications. | To compare the impact of 18F-sodium-fluoride (NaF) PET/CT, 18F-fluorocholine (FCH) PET/CT and diffusion-weighted whole-body MRI (DW-MRI) on the management of patients with prostate cancer (PCa) suspicious for distant metastasis.</AbstractText Prostate cancer patients were prospectively included between December 2011 an... | The purpose of this article is to review current image acquisition and interpretation for whole-body MRI, clinical applications, and the emerging roles in oncologic imaging, especially in the assessment of bone marrow diseases.</AbstractText Whole-body MRI is an emerging technique used for early diagnosis, staging, and... | A low-power wireless acoustic sensing platform for remote surveillance applications based on a 180 nm CMOS technology is proposed in this paper. The audio signal, which is acquired by a microphone, is first amplified and filtered. Then, the analog signal is converted to a digital signal by a 10-bit analog-to-digital co... | Impact of sodium (18)F-fluoride PET/CT, (18)F-fluorocholine PET/CT and whole-body diffusion-weighted MRI on the management of patients with prostate cancer suspicious for metastasis: a prospective multicentre study. To compare the impact of 18F-sodium-fluoride (NaF) PET/CT, 18F-fluorocholine (FCH) PET/CT and diffusion-... | Whole-Body MRI: Current Applications in Oncology. The purpose of this article is to review current image acquisition and interpretation for whole-body MRI, clinical applications, and the emerging roles in oncologic imaging, especially in the assessment of bone marrow diseases.</AbstractText Whole-body MRI is an emergin... | A Low-Power CMOS Wireless Acoustic Sensing Platform for Remote Surveillance Applications. A low-power wireless acoustic sensing platform for remote surveillance applications based on a 180 nm CMOS technology is proposed in this paper. The audio signal, which is acquired by a microphone, is first amplified and filtered.... |
40422416 | 33343039 | 40476782 | A Semantic Generalization of Shannon's Information Theory and Applications. | Active inference on discrete state-spaces: A synthesis. | Dixon-Based Water T1 Mapping for Fat-Corrected Assessment of Hepatic Fibrosis in Chronic Liver Disease. | Does semantic communication require a semantic information theory parallel to Shannon's information theory, or can Shannon's work be generalized for semantic communication? This paper advocates for the latter and introduces a semantic generalization of Shannon's information theory (G theory for short). The core idea is... | Active inference is a normative principle underwriting perception, action, planning, decision-making and learning in biological or artificial agents. From its inception, its associated process theory has grown to incorporate complex generative models, enabling simulation of a wide range of complex behaviours. Due to su... | The diagnostic value of conventional T1 mapping for noninvasive assessment of liver fibrosis is limited in the presence of hepatic steatosis. To evaluate the diagnostic value of water T1 (wT1) with continuous inversion-recovery Look-Locker (CIR-LL) method, integrating spiral readout, Dixon, and dictionary-based process... | A Semantic Generalization of Shannon's Information Theory and Applications. Does semantic communication require a semantic information theory parallel to Shannon's information theory, or can Shannon's work be generalized for semantic communication? This paper advocates for the latter and introduces a semantic generaliz... | Active inference on discrete state-spaces: A synthesis. Active inference is a normative principle underwriting perception, action, planning, decision-making and learning in biological or artificial agents. From its inception, its associated process theory has grown to incorporate complex generative models, enabling sim... | Dixon-Based Water T1 Mapping for Fat-Corrected Assessment of Hepatic Fibrosis in Chronic Liver Disease. The diagnostic value of conventional T1 mapping for noninvasive assessment of liver fibrosis is limited in the presence of hepatic steatosis. To evaluate the diagnostic value of water T1 (wT1) with continuous inversi... |
39859050 | 37968392 | 40371542 | Differentiating Apical and Basal Left Ventricular Aneurysms Using Sphericity Index: A Clinical Study. | CD201(+) fascia progenitors choreograph injury repair. | Polyphenisms in the reproductive response of male quail to short days are driven by testosterone-independent uncoupling in the photoperiodic TSH-DIO2/DIO3 pathway. | <i | Optimal tissue recovery and organismal survival are achieved by spatiotemporal tuning of tissue inflammation, contraction and scar formation<sup | The neuroendocrine control of seasonal breeding in vertebrates depends upon a TSH/DIO2-3 pathway located in the medio-basal hypothalamus. In male quail, early data demonstrated that this photoperiodic control is independent of testosterone. At least two strong predictions arise from this. First, testosterone is unlikel... | Differentiating Apical and Basal Left Ventricular Aneurysms Using Sphericity Index: A Clinical Study. <i | CD201(+) fascia progenitors choreograph injury repair. Optimal tissue recovery and organismal survival are achieved by spatiotemporal tuning of tissue inflammation, contraction and scar formation<sup | Polyphenisms in the reproductive response of male quail to short days are driven by testosterone-independent uncoupling in the photoperiodic TSH-DIO2/DIO3 pathway. The neuroendocrine control of seasonal breeding in vertebrates depends upon a TSH/DIO2-3 pathway located in the medio-basal hypothalamus. In male quail, ear... |
34322861 | 30242519 | 33831597 | gammaCore for Cluster Headaches: A NICE Medical Technologies Guidance. | Migraine and cluster headache - the common link. | Proteomic analysis of Caenorhabditis elegans wound model reveals novel molecular players involved in repair. | Cluster headaches are excruciating attacks of pain that can last between 15 min and 3 h. Cluster headaches can be episodic, where patients have long pain-free intervals between attacks, or chronic, where they do not. As part of the Medical Technologies Evaluation Programme, the UK National Institute for Health and Care... | Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP mo... | Wound repair is a multistep process which involves coordination of multiple molecular players from different cell types and pathways. Though the cellular processes that are taking place in order to repair damage is already known, molecular players involved in crucial pathways are still scarce. In this regard, the prese... | gammaCore for Cluster Headaches: A NICE Medical Technologies Guidance. Cluster headaches are excruciating attacks of pain that can last between 15 min and 3 h. Cluster headaches can be episodic, where patients have long pain-free intervals between attacks, or chronic, where they do not. As part of the Medical Technolog... | Migraine and cluster headache - the common link. Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. ... | Proteomic analysis of Caenorhabditis elegans wound model reveals novel molecular players involved in repair. Wound repair is a multistep process which involves coordination of multiple molecular players from different cell types and pathways. Though the cellular processes that are taking place in order to repair damage... |
15120171 | 15122676 | 15300207 | Cardiac phosphorus-31 two-dimensional chemical shift imaging in patients with hereditary hemochromatosis. | Quantitative description of proton exchange processes between water and endogenous and exogenous agents for WEX, CEST, and APT experiments. | Murine hindlimb reperfusion injury can be initiated by a self-reactive monoclonal IgM. | Hemochromatosis is a hereditary iron overload syndrome characterized by increased iron storage, followed by liver cirrhosis and is often associated with restrictive cardiomyopathy. The purpose of this study was to detect alterations of cardiac high-energy phosphate metabolism in patients with hereditary hemochromatosis... | The proton exchange processes between water and solutes containing exchangeable protons have recently become of interest for monitoring pH effects, detecting cellular mobile proteins and peptides, and enhancing the detection sensitivity of various low-concentration endogenous and exogenous species. In this work, the an... | Murine hindlimb reperfusion injury (I/R), is initiated by activation of the classical pathway of complement. Complement receptor-2 knockout mice (Cr2-/-) are protected from I/R injury due to defective B-1 cells with a resulting deficient natural immunoglobulin M (IgM) repertoire. Cr2-/- and wild type (WT) mice were stu... | Cardiac phosphorus-31 two-dimensional chemical shift imaging in patients with hereditary hemochromatosis. Hemochromatosis is a hereditary iron overload syndrome characterized by increased iron storage, followed by liver cirrhosis and is often associated with restrictive cardiomyopathy. The purpose of this study was to ... | Quantitative description of proton exchange processes between water and endogenous and exogenous agents for WEX, CEST, and APT experiments. The proton exchange processes between water and solutes containing exchangeable protons have recently become of interest for monitoring pH effects, detecting cellular mobile protei... | Murine hindlimb reperfusion injury can be initiated by a self-reactive monoclonal IgM. Murine hindlimb reperfusion injury (I/R), is initiated by activation of the classical pathway of complement. Complement receptor-2 knockout mice (Cr2-/-) are protected from I/R injury due to defective B-1 cells with a resulting defic... |
22182778 | 19458219 | 22809782 | Prolonged exposure to NMDAR antagonist induces cell-type specific changes of glutamatergic receptors in rat prefrontal cortex. | Synaptic scaling requires the GluR2 subunit of the AMPA receptor. | Validity of the American College of Rheumatology criteria for the diagnosis of giant cell arteritis. | N-methyl-d-aspartic acid (NMDA) receptors are critical for both normal brain functions and the pathogenesis of schizophrenia. We investigated the functional changes of glutamatergic receptors in the pyramidal cells and fast-spiking (FS) interneurons in the adolescent rat prefrontal cortex in MK-801 model of schizophren... | Two functionally distinct forms of synaptic plasticity, Hebbian long-term potentiation (LTP) and homeostatic synaptic scaling, are thought to cooperate to promote information storage and circuit refinement. Both arise through changes in the synaptic accumulation of AMPA receptors (AMPARs), but whether they use similar ... | To assess the clinical utility of the American College of Rheumatology criteria for the diagnosis of giant cell arteritis (GCA) in patients with positive and negative temporal artery biopsies.</AbstractText Retrospective case series of all patients undergoing temporal artery biopsy.</AbstractText Retrospective chart re... | Prolonged exposure to NMDAR antagonist induces cell-type specific changes of glutamatergic receptors in rat prefrontal cortex. N-methyl-d-aspartic acid (NMDA) receptors are critical for both normal brain functions and the pathogenesis of schizophrenia. We investigated the functional changes of glutamatergic receptors i... | Synaptic scaling requires the GluR2 subunit of the AMPA receptor. Two functionally distinct forms of synaptic plasticity, Hebbian long-term potentiation (LTP) and homeostatic synaptic scaling, are thought to cooperate to promote information storage and circuit refinement. Both arise through changes in the synaptic accu... | Validity of the American College of Rheumatology criteria for the diagnosis of giant cell arteritis. To assess the clinical utility of the American College of Rheumatology criteria for the diagnosis of giant cell arteritis (GCA) in patients with positive and negative temporal artery biopsies.</AbstractText Retrospectiv... |
39005951 | 30648799 | 38649908 | Evidence for Two Types of Task Conflict in a Color-Digit Stroop Task. | Disentangling the Mechanisms of Symbolic Number Processing in Adults' Mathematics and Arithmetic Achievement. | Interruptible demyelination in avian riboflavin deficient neuropathy. | In the present study, we conducted a Stroop-like task in which the participants were required to decide whether the presented stimulus, which could be either a colored digit or a colored rectangle, consisted of more or less than five colors. Like other Stroop-like tasks, the stimuli could be congruent (the stimulus was... | A growing body of research has shown that symbolic number processing relates to individual differences in mathematics. However, it remains unclear which mechanisms of symbolic number processing are crucial-accessing underlying magnitude representation of symbols (i.e., symbol-magnitude associations), processing relativ... | The evolution of demyelination in individual internodes remains unclear although it has been noticed the paranodal demyelination precedes internodal demyelination in neuropathies with diverse aetiologies. For therapeutic purpose, it is fundamental to know whether the demyelinating procedure in affected internodes can b... | Evidence for Two Types of Task Conflict in a Color-Digit Stroop Task. In the present study, we conducted a Stroop-like task in which the participants were required to decide whether the presented stimulus, which could be either a colored digit or a colored rectangle, consisted of more or less than five colors. Like oth... | Disentangling the Mechanisms of Symbolic Number Processing in Adults' Mathematics and Arithmetic Achievement. A growing body of research has shown that symbolic number processing relates to individual differences in mathematics. However, it remains unclear which mechanisms of symbolic number processing are crucial-acce... | Interruptible demyelination in avian riboflavin deficient neuropathy. The evolution of demyelination in individual internodes remains unclear although it has been noticed the paranodal demyelination precedes internodal demyelination in neuropathies with diverse aetiologies. For therapeutic purpose, it is fundamental to... |
40464173 | 39568474 | 38659785 | Computer-Aided Decision Support Systems of Alzheimer's Disease Diagnosis - A Systematic Review. | FLEX-SMOTE: Synthetic over-sampling technique that flexibly adjusts to different minority class distributions. | Imaging of brain electric field networks with spatially resolved EEG. | The incidence of Alzheimer's disease is rising with the increasing elderly population worldwide. While no cure exists, early diagnosis can significantly slow disease progression. Computer-aided diagnostic systems are becoming critical tools for assisting in the early detection of Alzheimer's disease. In this systematic... | Class imbalance is a challenge that affects the prediction rate on a minority class. To remedy this problem, various SMOTEs (synthetic minority over-sampling techniques) have been designed to populate synthetic minority instances. Some SMOTEs operate on the border of a minority class, while others concentrate on the cl... | We present a method for spatially resolving the electric field potential throughout the entire volume of the human brain from electroencephalography (EEG) data. The method is <i | Computer-Aided Decision Support Systems of Alzheimer's Disease Diagnosis - A Systematic Review. The incidence of Alzheimer's disease is rising with the increasing elderly population worldwide. While no cure exists, early diagnosis can significantly slow disease progression. Computer-aided diagnostic systems are becomin... | FLEX-SMOTE: Synthetic over-sampling technique that flexibly adjusts to different minority class distributions. Class imbalance is a challenge that affects the prediction rate on a minority class. To remedy this problem, various SMOTEs (synthetic minority over-sampling techniques) have been designed to populate syntheti... | Imaging of brain electric field networks with spatially resolved EEG. We present a method for spatially resolving the electric field potential throughout the entire volume of the human brain from electroencephalography (EEG) data. The method is <i |
38102180 | 11990806 | 31068653 | Usefulness of thalamic beta activity for closed-loop therapy in essential tremor. | Comparison of atlas- and magnetic resonance imaging-based stereotactic targeting of the globus pallidus internus in the performance of deep brain stimulation for treatment of dystonia. | Further characterization of the zebrafish model of acrylamide acute neurotoxicity: gait abnormalities and oxidative stress. | A partial loss of effectiveness of deep brain stimulation of the ventral intermediate nucleus of the thalamus (VIM) has been reported in some patients with essential tremor (ET), possibly due to habituation to permanent stimulation. This study focused on the evolution of VIM local-field potentials (LFPs) data over time... | To assess the validity of relying on atlases during stereotactic neurosurgery, the authors compared target coordinates in the globus pallidus internus (GPi) obtained using magnetic resonance (MR) imaging with those determined using an atlas. The targets were used in deep brain stimulation (DBS) for the treatment of gen... | Occupational, accidental, or suicidal exposure to acrylamide (ACR) may result in a neurotoxic syndrome. Development of animal models of acrylamide neurotoxicity is necessary for increasing our mechanistic understanding of this syndrome and developing more effective therapies. A new model for acute ACR neurotoxicity has... | Usefulness of thalamic beta activity for closed-loop therapy in essential tremor. A partial loss of effectiveness of deep brain stimulation of the ventral intermediate nucleus of the thalamus (VIM) has been reported in some patients with essential tremor (ET), possibly due to habituation to permanent stimulation. This ... | Comparison of atlas- and magnetic resonance imaging-based stereotactic targeting of the globus pallidus internus in the performance of deep brain stimulation for treatment of dystonia. To assess the validity of relying on atlases during stereotactic neurosurgery, the authors compared target coordinates in the globus pa... | Further characterization of the zebrafish model of acrylamide acute neurotoxicity: gait abnormalities and oxidative stress. Occupational, accidental, or suicidal exposure to acrylamide (ACR) may result in a neurotoxic syndrome. Development of animal models of acrylamide neurotoxicity is necessary for increasing our mec... |
37053195 | 22450384 | 37134278 | In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson's disease using neuromelanin-sensitive MRI: Replication in two cohorts. | Effects of image distortion correction on voxel-based morphometry. | STING/TBK1 Regulates Inflammation in Macrophages and Titanium Particles-Induced Osteolysis. | Patients with Parkinson's disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson's disease simultaneously with magnetic resonance imaging (MRI). Neuromelanin-sensitive MRI... | We aimed to show that correcting image distortion significantly affects brain volumetry using voxel-based morphometry (VBM) and to assess whether the processing of distortion correction reduces system dependency.</AbstractText We obtained contiguous sagittal T(1)-weighted images of the brain from 22 healthy participant... | Inflammatory response in macrophages on account of prostheses-derived wear particles is the leading cause of artificial joint failure. However, the mechanism by which wear particles initiate macrophage inflammation has not been fully elucidated. Previous research studies have identified TANK-binding kinase 1 (TBK1) and... | In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson's disease using neuromelanin-sensitive MRI: Replication in two cohorts. Patients with Parkinson's disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substanti... | Effects of image distortion correction on voxel-based morphometry. We aimed to show that correcting image distortion significantly affects brain volumetry using voxel-based morphometry (VBM) and to assess whether the processing of distortion correction reduces system dependency.</AbstractText We obtained contiguous sag... | STING/TBK1 Regulates Inflammation in Macrophages and Titanium Particles-Induced Osteolysis. Inflammatory response in macrophages on account of prostheses-derived wear particles is the leading cause of artificial joint failure. However, the mechanism by which wear particles initiate macrophage inflammation has not been ... |
40694026 | 24634081 | 39477489 | Veteran and Brain-Computer Interfaces: The Duty to Care. | Brain images, babies, and bathwater: critiquing critiques of functional neuroimaging. | Impact of Obesity on Short-Term Outcomes Following Catheter Ablation for Atrial Fibrillation in Patients with Heart Failure. | Anticipated by science fiction, the enhanced soldier crystallized in the United States at the dawn of the 21st century within the Pentagon's scientific agency, the Defense Advanced Research Projects Agency (DARPA). Fueled by the fear of being overtaken by the enemy, and then by its own technology, this agency's new vis... | Since the mid-1980s, psychologists and neuroscientists have used brain imaging to test hypotheses about human thought processes and their neural instantiation. In just three decades, functional neuroimaging has been transformed from a crude clinical tool to a widely used research method for understanding the human brai... | This study aimed to evaluate the impact of obesity on in-hospital outcomes of patients with HF undergoing AF catheter ablation. This population-based, retrospective observational study extracted data from the US Nationwide Inpatient Sample (NIS) database 2005-2018. Patients ≥ 20 years with HF and undergoing cath... | Veteran and Brain-Computer Interfaces: The Duty to Care. Anticipated by science fiction, the enhanced soldier crystallized in the United States at the dawn of the 21st century within the Pentagon's scientific agency, the Defense Advanced Research Projects Agency (DARPA). Fueled by the fear of being overtaken by the ene... | Brain images, babies, and bathwater: critiquing critiques of functional neuroimaging. Since the mid-1980s, psychologists and neuroscientists have used brain imaging to test hypotheses about human thought processes and their neural instantiation. In just three decades, functional neuroimaging has been transformed from a... | Impact of Obesity on Short-Term Outcomes Following Catheter Ablation for Atrial Fibrillation in Patients with Heart Failure. This study aimed to evaluate the impact of obesity on in-hospital outcomes of patients with HF undergoing AF catheter ablation. This population-based, retrospective observational study extracted ... |
37538852 | 35066157 | 37883030 | Otoferlin as a multirole Ca(2+) signaling protein: from inner ear synapses to cancer pathways. | Hemodynamic and metabolic correspondence of resting-state voxel-based physiological metrics in healthy adults. | The role of numerical and nonnumerical magnitudes in pigeons' conditional discrimination behavior. | Humans have six members of the ferlin protein family: dysferlin, myoferlin, otoferlin, fer1L4, fer1L5, and fer1L6. These proteins share common features such as multiple Ca<sup | Voxel-based physiological (VBP) variables derived from blood oxygen level dependent (BOLD) fMRI time-course variations include: amplitude of low frequency fluctuations (ALFF), fractional amplitude of low frequency fluctuations (fALFF) and regional homogeneity (ReHo). Although these BOLD-derived variables can detect bet... | Research on approximate numerical estimation suggests that numerical representations can be influenced by nonnumerical magnitudes. Current theories of numerical cognition differ on the nature of this interaction. The present project evaluated the effect of task requirements on the stimulus control exerted by numerical ... | Otoferlin as a multirole Ca(2+) signaling protein: from inner ear synapses to cancer pathways. Humans have six members of the ferlin protein family: dysferlin, myoferlin, otoferlin, fer1L4, fer1L5, and fer1L6. These proteins share common features such as multiple Ca<sup | Hemodynamic and metabolic correspondence of resting-state voxel-based physiological metrics in healthy adults. Voxel-based physiological (VBP) variables derived from blood oxygen level dependent (BOLD) fMRI time-course variations include: amplitude of low frequency fluctuations (ALFF), fractional amplitude of low frequ... | The role of numerical and nonnumerical magnitudes in pigeons' conditional discrimination behavior. Research on approximate numerical estimation suggests that numerical representations can be influenced by nonnumerical magnitudes. Current theories of numerical cognition differ on the nature of this interaction. The pres... |
33490982 | 33582224 | 34400267 | Protocol for pressure-clamped patch-clamp recording at the node of Ranvier of rat myelinated nerves. | Mitochondria and calcium defects correlate with axonal dysfunction in GDAP1-related Charcot-Marie-Tooth mouse model. | Dosimetric Uncertainties Resulting From Interfractional Anatomic Variations for Patients Receiving Pancreas Stereotactic Body Radiation Therapy and Cone Beam Computed Tomography Image Guidance. | The patch-clamp recording technique is indispensable for studying ion channel functions of cells but is challenging to apply to the node of Ranvier, a key site where action potentials are conducted along myelinated nerves. We have developed a pressure-clamped patch-clamp recording method applying to the node of Ranvier... | Ganglioside-induced differentiation associated protein 1 (GDAP1) gene encodes a protein of the mitochondrial outer membrane and of the mitochondrial membrane contacts with the endoplasmic reticulum (MAMs) and lysosomes. Since mutations in GDAP1 cause Charcot-Marie-Tooth, an inherited motor and sensory neuropathy, its f... | To estimate the effects of interfractional anatomic changes on dose to organs at risk (OARs) and tumors, as measured with cone beam computed tomography (CBCT) image guidance for pancreatic stereotactic body radiation therapy.</AbstractText We evaluated 11 patients with pancreatic cancer whom were treated with stereotac... | Protocol for pressure-clamped patch-clamp recording at the node of Ranvier of rat myelinated nerves. The patch-clamp recording technique is indispensable for studying ion channel functions of cells but is challenging to apply to the node of Ranvier, a key site where action potentials are conducted along myelinated nerv... | Mitochondria and calcium defects correlate with axonal dysfunction in GDAP1-related Charcot-Marie-Tooth mouse model. Ganglioside-induced differentiation associated protein 1 (GDAP1) gene encodes a protein of the mitochondrial outer membrane and of the mitochondrial membrane contacts with the endoplasmic reticulum (MAMs... | Dosimetric Uncertainties Resulting From Interfractional Anatomic Variations for Patients Receiving Pancreas Stereotactic Body Radiation Therapy and Cone Beam Computed Tomography Image Guidance. To estimate the effects of interfractional anatomic changes on dose to organs at risk (OARs) and tumors, as measured with cone... |
35903637 | 29278773 | 35203050 | Resting-State Brain Variability in Youth With Attention-Deficit/Hyperactivity Disorder. | An evaluation of the efficacy, reliability, and sensitivity of motion correction strategies for resting-state functional MRI. | Generation of a human iPSC line (UUIGPi015-A) from a patient with Dravet syndrome and a 2.9 Mb deletion spanning SCN1A on chromosome 2. | In this study, we sought to determine the nature of the abnormality in resting-state default mode network (DMN) activation and explore its correlation with functional connectivity in attention-deficit/hyperactivity disorder (ADHD). We obtained resting-state functional magnetic resonance images of youth with ADHD and ty... | Estimates of functional connectivity derived from resting-state functional magnetic resonance imaging (rs-fMRI) are sensitive to artefacts caused by in-scanner head motion. This susceptibility has motivated the development of numerous denoising methods designed to mitigate motion-related artefacts. Here, we compare pop... | Dravet syndrome is an early onset devastating epilepsy syndrome usually caused by heterozygous mutations in SCN1A. We generated a human iPSC line (UUIGPi015-A) from dermal fibroblasts of a patient with Dravet syndrome carrying a deletion on chromosome 2 encompassing SCN1A and 9 flanking genes. Characterization of the i... | Resting-State Brain Variability in Youth With Attention-Deficit/Hyperactivity Disorder. In this study, we sought to determine the nature of the abnormality in resting-state default mode network (DMN) activation and explore its correlation with functional connectivity in attention-deficit/hyperactivity disorder (ADHD). ... | An evaluation of the efficacy, reliability, and sensitivity of motion correction strategies for resting-state functional MRI. Estimates of functional connectivity derived from resting-state functional magnetic resonance imaging (rs-fMRI) are sensitive to artefacts caused by in-scanner head motion. This susceptibility h... | Generation of a human iPSC line (UUIGPi015-A) from a patient with Dravet syndrome and a 2.9 Mb deletion spanning SCN1A on chromosome 2. Dravet syndrome is an early onset devastating epilepsy syndrome usually caused by heterozygous mutations in SCN1A. We generated a human iPSC line (UUIGPi015-A) from dermal fibroblasts ... |
40149575 | 37061720 | 40721529 | The Impact of Visualization on Stroke Rehabilitation in Adults: A Systematic Review of Randomized Controlled Trials on Guided and Motor Imagery. | Recommendations for progression criteria during external randomised pilot trial design, conduct, analysis and reporting. | The LISTEN principles for genetic sequence data governance and database engineering. | <b | External randomised pilot trials aim to assess whether a future definitive Randomised Controlled Trial (RCT) is feasible. Prespecified progression criteria help guide the interpretation of pilot trial findings to decide whether, and how, a definitive RCT should be conducted. This commentary presents a set of proposed r... | Several international legal agreements include an 'access and benefit-sharing' (ABS) mechanism that attaches obligations to the use of genetic sequence data. These agreements are frequently subject to critique on the grounds that ABS is either fundamentally incompatible with the principles of open science, or technical... | The Impact of Visualization on Stroke Rehabilitation in Adults: A Systematic Review of Randomized Controlled Trials on Guided and Motor Imagery. <b | Recommendations for progression criteria during external randomised pilot trial design, conduct, analysis and reporting. External randomised pilot trials aim to assess whether a future definitive Randomised Controlled Trial (RCT) is feasible. Prespecified progression criteria help guide the interpretation of pilot tria... | The LISTEN principles for genetic sequence data governance and database engineering. Several international legal agreements include an 'access and benefit-sharing' (ABS) mechanism that attaches obligations to the use of genetic sequence data. These agreements are frequently subject to critique on the grounds that ABS i... |
38009961 | 25867615 | 38569727 | Prolonged neural encoding of visual information in autism. | Central and peripheral vision loss differentially affects contextual cueing in visual search. | Bulky malignant peripheral nerve sheath tumour of the left thigh in a pregnant woman presenting with a pathological fracture of the proximal femur. | Autism spectrum disorder (ASD) is associated with a hyper-focused visual attentional style, impacting higher-order social and affective domains. The understanding of such peculiarity can benefit from the use of multivariate pattern analysis (MVPA) of high-resolution electroencephalography (EEG) data, which has proved t... | Visual search for targets in repeated displays is more efficient than search for the same targets in random distractor layouts. Previous work has shown that this contextual cueing is severely impaired under central vision loss. Here, we investigated whether central vision loss, simulated with gaze-contingent displays, ... | Malignant peripheral nerve sheath tumour (MPNST) is an aggressive soft tissue sarcoma with a poor prognosis, affecting most commonly the extremities. The lungs constitute the most frequent location for distant metastases. Half of all MPNSTs arise in patients with neurofibromatosis type 1, while approximately 10% are ra... | Prolonged neural encoding of visual information in autism. Autism spectrum disorder (ASD) is associated with a hyper-focused visual attentional style, impacting higher-order social and affective domains. The understanding of such peculiarity can benefit from the use of multivariate pattern analysis (MVPA) of high-resol... | Central and peripheral vision loss differentially affects contextual cueing in visual search. Visual search for targets in repeated displays is more efficient than search for the same targets in random distractor layouts. Previous work has shown that this contextual cueing is severely impaired under central vision loss... | Bulky malignant peripheral nerve sheath tumour of the left thigh in a pregnant woman presenting with a pathological fracture of the proximal femur. Malignant peripheral nerve sheath tumour (MPNST) is an aggressive soft tissue sarcoma with a poor prognosis, affecting most commonly the extremities. The lungs constitute t... |
35665225 | 23994479 | 35438398 | Inhibitory Spike-Timing-Dependent Plasticity Can Account for Pathological Strengthening of Pallido-Subthalamic Synapses in Parkinson's Disease. | Preconfigured, skewed distribution of firing rates in the hippocampus and entorhinal cortex. | Impact of financial inclusion and globalization on environmental quality: evidence from G20 economies. | Parkinson's disease (PD) is a neurodegenerative brain disorder associated with dysfunction of the basal ganglia (BG) circuitry. Dopamine (DA) depletion in experimental PD models leads to the pathological strengthening of pallido-subthalamic synaptic connections, contributing to the emergence of abnormally synchronized ... | Despite the importance of the discharge frequency in neuronal communication, little is known about the firing-rate patterns of cortical populations. Using large-scale recordings from multiple layers of the entorhinal-hippocampal loop, we found that the firing rates of principal neurons showed a lognormal-like distribut... | Sustainable development and addressing climate change are among the most pressing issues faced by countries around the world. This research investigates the dynamic associations between financial inclusion, globalization and CO<sub | Inhibitory Spike-Timing-Dependent Plasticity Can Account for Pathological Strengthening of Pallido-Subthalamic Synapses in Parkinson's Disease. Parkinson's disease (PD) is a neurodegenerative brain disorder associated with dysfunction of the basal ganglia (BG) circuitry. Dopamine (DA) depletion in experimental PD model... | Preconfigured, skewed distribution of firing rates in the hippocampus and entorhinal cortex. Despite the importance of the discharge frequency in neuronal communication, little is known about the firing-rate patterns of cortical populations. Using large-scale recordings from multiple layers of the entorhinal-hippocampa... | Impact of financial inclusion and globalization on environmental quality: evidence from G20 economies. Sustainable development and addressing climate change are among the most pressing issues faced by countries around the world. This research investigates the dynamic associations between financial inclusion, globalizat... |
34089103 | 29354050 | 36162735 | Intra- and interhemispheric symmetry of subcortical brain structures: a volumetric analysis in the aging human brain. | Brain Network Modularity Predicts Exercise-Related Executive Function Gains in Older Adults. | Phldb2 is essential for regulating hippocampal dendritic spine morphology through drebrin in an adult-type isoform-specific manner. | Here, we address the hemispheric interdependency of subcortical structures in the aging human brain. In particular, we investigated whether subcortical volume variations can be explained by the adjacency of structures in the same hemisphere or are due to the interhemispheric development of mirror subcortical structures... | Recent work suggests that the brain can be conceptualized as a network comprised of groups of sub-networks or modules. The extent of segregation between modules can be quantified with a modularity metric, where networks with high modularity have dense connections within modules and sparser connections between modules. ... | Morphologically dynamic dendritic spines are the major sites of neuronal plasticity in the brain; however, the molecular mechanisms underlying their morphological dynamics have not been fully elucidated. Phldb2 is a protein that contains two predicted coiled-coil domains and the pleckstrin homology domain, whose bindin... | Intra- and interhemispheric symmetry of subcortical brain structures: a volumetric analysis in the aging human brain. Here, we address the hemispheric interdependency of subcortical structures in the aging human brain. In particular, we investigated whether subcortical volume variations can be explained by the adjacenc... | Brain Network Modularity Predicts Exercise-Related Executive Function Gains in Older Adults. Recent work suggests that the brain can be conceptualized as a network comprised of groups of sub-networks or modules. The extent of segregation between modules can be quantified with a modularity metric, where networks with hi... | Phldb2 is essential for regulating hippocampal dendritic spine morphology through drebrin in an adult-type isoform-specific manner. Morphologically dynamic dendritic spines are the major sites of neuronal plasticity in the brain; however, the molecular mechanisms underlying their morphological dynamics have not been fu... |
36182711 | 31649571 | 36069044 | The Flow-Clutch Scale: Translation and validation study of the Chinese version. | Can We Motivate Students to Practice Physical Activities and Sports Through Models-Based Practice? A Systematic Review and Meta-Analysis of Psychosocial Factors Related to Physical Education. | Pilot Study of Associations Among Functional Connectivity and Neurocognition in Survivors of Pediatric Brain Tumor and Healthy Peers. | The integrated model of flow and clutch provides a multistate perspective to the optimal experiences during physical exercises. Based on this model, the Flow-Clutch Scale (FCS) was developed. The current study is the first step to test the psychometric properties of a Chinese version of the FCS (FCS-C).</AbstractText A... | Adults (more than 18 years old) are likely to reproduce the habits that they acquired during childhood and adolescence (from 6 to 16 years old). For that reason, teachers and parents have the responsibility to promote an active and healthy lifestyle in children and adolescents. Even though every school subject should p... | This pilot study examined the associations among functional connectivity in the salience, central executive, and default mode networks, and neurocognition in pediatric brain tumor survivors and healthy children. Thirteen pediatric brain tumor survivors (9 boys, M = 12.76 years) and 10 healthy children (6 ... | The Flow-Clutch Scale: Translation and validation study of the Chinese version. The integrated model of flow and clutch provides a multistate perspective to the optimal experiences during physical exercises. Based on this model, the Flow-Clutch Scale (FCS) was developed. The current study is the first step to test the ... | Can We Motivate Students to Practice Physical Activities and Sports Through Models-Based Practice? A Systematic Review and Meta-Analysis of Psychosocial Factors Related to Physical Education. Adults (more than 18 years old) are likely to reproduce the habits that they acquired during childhood and adolescence (from 6 t... | Pilot Study of Associations Among Functional Connectivity and Neurocognition in Survivors of Pediatric Brain Tumor and Healthy Peers. This pilot study examined the associations among functional connectivity in the salience, central executive, and default mode networks, and neurocognition in pediatric brain tumor surviv... |
33989467 | 32733110 | 33619879 | How to Evaluate Patients and Educate Them About Self-Examinations for Tardive Dyskinesia Between Appointments. | Assesment of Risk Factors for Tardive Dyskinesia. | External validation and comparison of current scoring systems in retrograde intrarenal surgery: Multi-institutional study with 949 patients. | Patients taking dopamine-blocking agents such as antipsychotics are at risk for developing tardive dyskinesia. In this webcast, Drs McEvoy and Nierenberg discuss symptoms of tardive dyskinesia, how to observe patients (whether in person or via telemedicine), and how to educate patients and families about TD.</AbstractT... | Aim of the study is to evaluate sociodemographic and clinical features that may be associated with the development of Tardive dyskinesia (TD).</AbstractText 80 patients attending an outpatient psychiatry clinic in Istanbul, Turkey were divided into TD (n = 50) and control groups (CG) (n = 30). Sociodemographic and clin... | To externally validate and compare Resorlu-Unsal stone score (RUSS), modified Seoul National University Renal Stone Complexity Score(S-ReSC), Ito's nomogram, and Retrograde Intra-Renal Surgery (R.I.R.S.) scoring systems for predicting capabilities of both the stone-free status and complications in a multi-institutional... | How to Evaluate Patients and Educate Them About Self-Examinations for Tardive Dyskinesia Between Appointments. Patients taking dopamine-blocking agents such as antipsychotics are at risk for developing tardive dyskinesia. In this webcast, Drs McEvoy and Nierenberg discuss symptoms of tardive dyskinesia, how to observe ... | Assesment of Risk Factors for Tardive Dyskinesia. Aim of the study is to evaluate sociodemographic and clinical features that may be associated with the development of Tardive dyskinesia (TD).</AbstractText 80 patients attending an outpatient psychiatry clinic in Istanbul, Turkey were divided into TD (n = 50) and contr... | External validation and comparison of current scoring systems in retrograde intrarenal surgery: Multi-institutional study with 949 patients. To externally validate and compare Resorlu-Unsal stone score (RUSS), modified Seoul National University Renal Stone Complexity Score(S-ReSC), Ito's nomogram, and Retrograde Intra-... |
39199438 | 17610823 | 39173841 | Multiple Types of Developmental Dyslexias in a Shallow Orthography: Principles for Diagnostic Screening in Italian. | Hierarchical coding of letter strings in the ventral stream: dissecting the inner organization of the visual word-form system. | Acute exercise might not affect subsequent appetite responses to a fixed meal in adolescents with obesity: The SMASH exploratory study. | A new dyslexia screening test for Italian, <i | Visual word recognition has been proposed to rely on a hierarchy of increasingly complex neuronal detectors, from individual letters to bigrams and morphemes. We used fMRI to test whether such a hierarchy is present in the left occipitotemporal cortex, at the site of the visual word-form area, and with an anterior-to-p... | While an intensity-dependent post-exercise decrease in energy intake (EI) has been described in adolescents with obesity, studies invariably used ad libitum meals, limiting then any conclusions regarding the effect of exercise on post-meal appetitive responses that can be also impacted by the ad libitum nature of the m... | Multiple Types of Developmental Dyslexias in a Shallow Orthography: Principles for Diagnostic Screening in Italian. A new dyslexia screening test for Italian, <i | Hierarchical coding of letter strings in the ventral stream: dissecting the inner organization of the visual word-form system. Visual word recognition has been proposed to rely on a hierarchy of increasingly complex neuronal detectors, from individual letters to bigrams and morphemes. We used fMRI to test whether such ... | Acute exercise might not affect subsequent appetite responses to a fixed meal in adolescents with obesity: The SMASH exploratory study. While an intensity-dependent post-exercise decrease in energy intake (EI) has been described in adolescents with obesity, studies invariably used ad libitum meals, limiting then any co... |
40213932 | 29862158 | 40415631 | Evolution of Brain Magnetic Resonance Imaging Lesions in Dogs Treated for Meningoencephalomyelitis of Unknown Origin Between Initial Diagnosis and Relapse. | Severe bacterial sepsis results in delayed diagnosis of tuberculous lymphadenitis in a rheumatoid arthritis patient treated with adalimumab. | Centering U.S. Rural, Immigrant Latinx Adolescent Voices Through Narrative Mapping: Exploring a Novel Approach to Communicated Narrative Sense-Making. | The response of meningoencephalitis of unknown origin (MUO) in dogs to immunosuppressive treatment is unpredictable, and relapses frequently occur.</AbstractText Our aim was to describe the evolution of brain magnetic resonance imaging (MRI) lesions in dogs treated for MUO from diagnosis to relapse and to define the di... | Although tumor necrosis factor (TNF)-α inhibitors are effective in patients with rheumatoid arthritis (RA), an increased risk of infections often becomes a serious problem. It is well known that TNF-α inhibitors increase the risk of tuberculosis, but extrapulmonary tuberculosis often induced by them is diff... | In the current study, we explore how rural immigrant Latinx adolescents make sense of and cope with their experiences through narrative mapping. Narrative mapping is an arts-based research method consisting of intrapersonal sensemaking through drawing and interpersonal sensemaking through discussion with others. We the... | Evolution of Brain Magnetic Resonance Imaging Lesions in Dogs Treated for Meningoencephalomyelitis of Unknown Origin Between Initial Diagnosis and Relapse. The response of meningoencephalitis of unknown origin (MUO) in dogs to immunosuppressive treatment is unpredictable, and relapses frequently occur.</AbstractText Ou... | Severe bacterial sepsis results in delayed diagnosis of tuberculous lymphadenitis in a rheumatoid arthritis patient treated with adalimumab. Although tumor necrosis factor (TNF)-α inhibitors are effective in patients with rheumatoid arthritis (RA), an increased risk of infections often becomes a serious problem. ... | Centering U.S. Rural, Immigrant Latinx Adolescent Voices Through Narrative Mapping: Exploring a Novel Approach to Communicated Narrative Sense-Making. In the current study, we explore how rural immigrant Latinx adolescents make sense of and cope with their experiences through narrative mapping. Narrative mapping is an ... |
40464467 | 22086977 | 39466625 | Lamotrigine Enhances Autophagy and Reduces Post-Traumatic Spinal Neural Injury in Mice. | Homeostatic synaptic plasticity: local and global mechanisms for stabilizing neuronal function. | Accumbal serotonin hypofunction and dopamine hyperfunction due to chronic stress and palatable food intake in rats. | Lamotrigine (LTG) is an antiepileptic drug that stabilizes the presynaptic membrane by blocking sodium channels and inhibiting excessive glutamate release. Its neuroprotective effects have been demonstrated in various pathological states. However, the role of LTG in spinal cord injury (SCI) and its relationship with au... | Neural circuits must maintain stable function in the face of many plastic challenges, including changes in synapse number and strength, during learning and development. Recent work has shown that these destabilizing influences are counterbalanced by homeostatic plasticity mechanisms that act to stabilize neuronal and c... | <b | Lamotrigine Enhances Autophagy and Reduces Post-Traumatic Spinal Neural Injury in Mice. Lamotrigine (LTG) is an antiepileptic drug that stabilizes the presynaptic membrane by blocking sodium channels and inhibiting excessive glutamate release. Its neuroprotective effects have been demonstrated in various pathological s... | Homeostatic synaptic plasticity: local and global mechanisms for stabilizing neuronal function. Neural circuits must maintain stable function in the face of many plastic challenges, including changes in synapse number and strength, during learning and development. Recent work has shown that these destabilizing influenc... | Accumbal serotonin hypofunction and dopamine hyperfunction due to chronic stress and palatable food intake in rats. <b |
35911892 | 25043498 | 36179465 | Clinical Spectrum of Tauopathies. | Voxelwise meta-analysis of gray matter abnormalities in dementia with Lewy bodies. | Ultrafast cervcial spine MRI protocol using deep learning-based reconstruction: Diagnostic equivalence to a conventional protocol. | Tauopathies are both clinical and pathological heterogeneous disorders characterized by neuronal and/or glial accumulation of misfolded tau protein. It is now well understood that every pathologic tauopathy may present with various clinical phenotypes based on the primary site of involvement and the spread and distribu... | Increasing neuroimaging studies have revealed brain gray matter (GM) atrophy by voxel-based morphometry (VBM) studies in patients with dementia with Lewy bodies (DLB) relative to healthy controls. However, the spatial localization of GM abnormalities reported in the existing studies is heterogeneous. Here, we aimed to ... | A major drawback of magnetic resonance imaging (MRI) is its limited imaging speed. This study proposed an ultrafast cervical spine MRI protocol (2 min 57 s) using deep learning-based reconstruction (DLR) and compared the diagnostic results to those of conventional MRI protocols (12 min 54 s).</Abstr... | Clinical Spectrum of Tauopathies. Tauopathies are both clinical and pathological heterogeneous disorders characterized by neuronal and/or glial accumulation of misfolded tau protein. It is now well understood that every pathologic tauopathy may present with various clinical phenotypes based on the primary site of invol... | Voxelwise meta-analysis of gray matter abnormalities in dementia with Lewy bodies. Increasing neuroimaging studies have revealed brain gray matter (GM) atrophy by voxel-based morphometry (VBM) studies in patients with dementia with Lewy bodies (DLB) relative to healthy controls. However, the spatial localization of GM ... | Ultrafast cervcial spine MRI protocol using deep learning-based reconstruction: Diagnostic equivalence to a conventional protocol. A major drawback of magnetic resonance imaging (MRI) is its limited imaging speed. This study proposed an ultrafast cervical spine MRI protocol (2 min 57 s) using deep learning-ba... |
39846186 | 33971241 | 39494983 | Infarct core segmentation using U-Net in CT perfusion imaging: a feasibility study. | Diffusion kurtosis imaging for the assessment of renal fibrosis of chronic kidney disease: A preliminary study. | Dopaminergic Axon Tracts Within a Hyaluronic Acid Hydrogel Encasement to Restore the Nigrostriatal Pathway. | BackgroundThe wide variability in thresholds on computed tomography (CT) perfusion parametric maps has led to controversy in the stroke imaging community about the most accurate measurement of core infarction.PurposeTo investigate the feasibility of using U-Net to perform infarct core segmentation in CT perfusion imagi... | To investigate the potential of diffusion kurtosis imaging (DKI) for the assessment of renal fibrosis in chronic kidney disease (CKD), using histopathology as the reference standard.</AbstractText Eighty-nine CKD patients and twenty healthy volunteers were recruited in this study. DKI was performed in all participants ... | Parkinson's disease is characterized by motor deficits emerging from insufficient dopamine in the striatum after degeneration of dopaminergic neurons and their long-projecting axons comprising the nigrostriatal pathway. To address this, a tissue-engineered nigrostriatal pathway (TE-NSP) featuring a tubular hydrogel wit... | Infarct core segmentation using U-Net in CT perfusion imaging: a feasibility study. BackgroundThe wide variability in thresholds on computed tomography (CT) perfusion parametric maps has led to controversy in the stroke imaging community about the most accurate measurement of core infarction.PurposeTo investigate the f... | Diffusion kurtosis imaging for the assessment of renal fibrosis of chronic kidney disease: A preliminary study. To investigate the potential of diffusion kurtosis imaging (DKI) for the assessment of renal fibrosis in chronic kidney disease (CKD), using histopathology as the reference standard.</AbstractText Eighty-nine... | Dopaminergic Axon Tracts Within a Hyaluronic Acid Hydrogel Encasement to Restore the Nigrostriatal Pathway. Parkinson's disease is characterized by motor deficits emerging from insufficient dopamine in the striatum after degeneration of dopaminergic neurons and their long-projecting axons comprising the nigrostriatal p... |
39600178 | 20198109 | 40396896 | Organic NMR crystallography: enabling progress for applications to pharmaceuticals and plant cell walls. | DNP-Hyperpolarized C Magnetic Resonance Metabolic Imaging for Cancer Applications. | A Dyad Approach to Understanding Intimate Partner and Family Distress as Risk Factors for Poor Warfighter Brain Health Following Mild Traumatic Brain Injury in Military Couples. | The application of NMR crystallography to organic molecules is exemplified by two case studies. For the tosylate salt of the active pharmaceutical ingredient, Ritlectinib, solid-state NMR spectra are presented at a <sup | Critical factors in characterizing the aggressiveness and response to therapy for tumors are the availability of noninvasive biomarkers that can be combined with other clinical parameters to tailor treatment regimens to each individual patient. While conventional magnetic resonance (MR) images are widely used to estima... | Using a dyadic approach with military couples, the current study examined family risk factors for chronic neurobehavioral symptoms in service members and veterans (SMVs) following a mild traumatic brain injury (MTBI).</AbstractText Military Treatment Facility.</AbstractText SMV (n = 122) and intimate partner (IPs,... | Organic NMR crystallography: enabling progress for applications to pharmaceuticals and plant cell walls. The application of NMR crystallography to organic molecules is exemplified by two case studies. For the tosylate salt of the active pharmaceutical ingredient, Ritlectinib, solid-state NMR spectra are presented at a ... | DNP-Hyperpolarized C Magnetic Resonance Metabolic Imaging for Cancer Applications. Critical factors in characterizing the aggressiveness and response to therapy for tumors are the availability of noninvasive biomarkers that can be combined with other clinical parameters to tailor treatment regimens to each individual p... | A Dyad Approach to Understanding Intimate Partner and Family Distress as Risk Factors for Poor Warfighter Brain Health Following Mild Traumatic Brain Injury in Military Couples. Using a dyadic approach with military couples, the current study examined family risk factors for chronic neurobehavioral symptoms in service ... |
37802314 | 35549404 | 36754227 | A PrP EGFR signaling axis controls neural stem cell senescence through modulating cellular energy pathways. | The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. | Structural basis of botulinum neurotoxin serotype A1 binding to human SV2A or SV2C receptors. | Mis-folding of the prion protein (PrP) is known to cause neurodegenerative disease; however, the native function of this protein remains poorly defined. PrP has been linked with many cellular functions, including cellular proliferation and senescence. It is also known to influence epidermal growth factor receptor (EGFR... | Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the physiology of human organs. We created a human reference atlas comprising nearly 500,000 cells from 24 different tissues and organs, many from the same donor. This atlas... | Botulinum neurotoxin A1 (BoNT/A1) is the most potent natural poison in human. BoNT/A1 recognize the luminal domain of SV2A (LD-SV2A) and its glycosylation at position N573 (N573g) or the luminal domain of SV2C (LD-SV2C) and its glycosylation at position N559 (N559g) to bind neural membrane. Our computational data sugge... | A PrP EGFR signaling axis controls neural stem cell senescence through modulating cellular energy pathways. Mis-folding of the prion protein (PrP) is known to cause neurodegenerative disease; however, the native function of this protein remains poorly defined. PrP has been linked with many cellular functions, including... | The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the physiology of human organs. We created a human reference atlas comprising nearly 500,00... | Structural basis of botulinum neurotoxin serotype A1 binding to human SV2A or SV2C receptors. Botulinum neurotoxin A1 (BoNT/A1) is the most potent natural poison in human. BoNT/A1 recognize the luminal domain of SV2A (LD-SV2A) and its glycosylation at position N573 (N573g) or the luminal domain of SV2C (LD-SV2C) and it... |
40595725 | 36924923 | 40782980 | Dopaminergic and serotonergic genetic variants predict actions and expectations of cooperation and punishment. | The gut-brain connection: Exploring the influence of the gut microbiota on neuroplasticity and neurodevelopmental disorders. | Antibiotic Resistance, Biofilm Formation, and Virulence Gene Profiling of Multidrug-Resistant Pseudomonas aeruginosa Isolates from a Multi-Speciality Hospital in Sikkim, India. | Genetic variants in dopaminergic and serotonergic pathways have been linked to individual differences in social behavior. In this study, we investigated the relationship between eight allelic variants within these pathways and both behavior and beliefs in 99 participants playing an online Public Goods Game (PGG) with a... | Neuroplasticity refers to the ability of brain circuits to reorganize and change the properties of the network, resulting in alterations in brain function and behavior. It is traditionally believed that neuroplasticity is influenced by external stimuli, learning, and experience. Intriguingly, there is new evidence sugg... | Effective antibiotic stewardship and monitoring of antimicrobial resistance are crucial for mitigating the emergence and spread of opportunistic nosocomial pathogens, such as Pseudomonas aeruginosa. This study aimed to identify antibiotic resistance patterns, the ability to form biofilms, and the presence of virulence-... | Dopaminergic and serotonergic genetic variants predict actions and expectations of cooperation and punishment. Genetic variants in dopaminergic and serotonergic pathways have been linked to individual differences in social behavior. In this study, we investigated the relationship between eight allelic variants within t... | The gut-brain connection: Exploring the influence of the gut microbiota on neuroplasticity and neurodevelopmental disorders. Neuroplasticity refers to the ability of brain circuits to reorganize and change the properties of the network, resulting in alterations in brain function and behavior. It is traditionally believ... | Antibiotic Resistance, Biofilm Formation, and Virulence Gene Profiling of Multidrug-Resistant Pseudomonas aeruginosa Isolates from a Multi-Speciality Hospital in Sikkim, India. Effective antibiotic stewardship and monitoring of antimicrobial resistance are crucial for mitigating the emergence and spread of opportunisti... |
31954173 | 33192479 | 32811699 | Denoising arterial spin labeling perfusion MRI with deep machine learning. | Detection of Cerebrovascular Loss in the Normal Aging C57BL/6 Mouse Brain Using in vivo Contrast-Enhanced Magnetic Resonance Angiography. | Blood microRNA expressions in patients with mild to moderate psoriasis and the relationship between microRNAs and psoriasis activity. | Arterial spin labeling (ASL) perfusion MRI is a noninvasive technique for measuring cerebral blood flow (CBF) in a quantitative manner. A technical challenge in ASL MRI is data processing because of the inherently low signal-to-noise-ratio (SNR). Deep learning (DL) is an emerging machine learning technique that can lea... | Microvascular rarefaction, or the decrease in vascular density, has been described in the cerebrovasculature of aging humans, rats, and, more recently, mice in the presence and absence of age-dependent diseases. Given the wide use of mice in modeling age-dependent human diseases of the cerebrovasculature, visualization... | In recent studies, microRNAs (mi-RNAs) have been shown to play an important role in psoriasis pathogenesis. However, studies evaluating mi-RNAs in the blood of psoriasis patients including a large number of mi-RNA panels are scarce.</AbstractText The authors aimed to assess mi-RNA expressions in blood samples of psoria... | Denoising arterial spin labeling perfusion MRI with deep machine learning. Arterial spin labeling (ASL) perfusion MRI is a noninvasive technique for measuring cerebral blood flow (CBF) in a quantitative manner. A technical challenge in ASL MRI is data processing because of the inherently low signal-to-noise-ratio (SNR)... | Detection of Cerebrovascular Loss in the Normal Aging C57BL/6 Mouse Brain Using in vivo Contrast-Enhanced Magnetic Resonance Angiography. Microvascular rarefaction, or the decrease in vascular density, has been described in the cerebrovasculature of aging humans, rats, and, more recently, mice in the presence and absen... | Blood microRNA expressions in patients with mild to moderate psoriasis and the relationship between microRNAs and psoriasis activity. In recent studies, microRNAs (mi-RNAs) have been shown to play an important role in psoriasis pathogenesis. However, studies evaluating mi-RNAs in the blood of psoriasis patients includi... |
40618043 | 29856543 | 39838948 | Cross-cultural adaptation of the family coping questionnaire and psychometric evaluation among caregivers of schizophrenic patients in China. | What is the risk-benefit ratio of long-term antipsychotic treatment in people with schizophrenia? | Mass production of robust hydrogel electrolytes for high-performance zinc-ion batteries. | Schizophrenia is a significant public health concern in China, imposing a heavy burden on patients' families and the healthcare system. However, there is a lack of a specific questionnaire for family caregivers of schizophrenia patients in China. This study aimed to introduce and culturally adapt the Family Coping Ques... | The long-term benefit-to-risk ratio of sustained antipsychotic treatment for schizophrenia has recently been questioned. In this paper, we critically examine the literature on the long-term efficacy and effectiveness of this treatment. We also review the evidence on the undesired effects, the impact on physical morbidi... | Hydrogel electrolytes are crucial for solving the problems of random zinc dendrite growth, hydrogen evolution reactions, and uncontrollable passivation. However, their complex fabrication processes pose challenges to achieving large-scale production with excellent mechanical properties required to withstand multiple cy... | Cross-cultural adaptation of the family coping questionnaire and psychometric evaluation among caregivers of schizophrenic patients in China. Schizophrenia is a significant public health concern in China, imposing a heavy burden on patients' families and the healthcare system. However, there is a lack of a specific que... | What is the risk-benefit ratio of long-term antipsychotic treatment in people with schizophrenia? The long-term benefit-to-risk ratio of sustained antipsychotic treatment for schizophrenia has recently been questioned. In this paper, we critically examine the literature on the long-term efficacy and effectiveness of th... | Mass production of robust hydrogel electrolytes for high-performance zinc-ion batteries. Hydrogel electrolytes are crucial for solving the problems of random zinc dendrite growth, hydrogen evolution reactions, and uncontrollable passivation. However, their complex fabrication processes pose challenges to achieving larg... |
20955933 | 20546078 | 20028933 | The genetics of child psychiatric disorders: focus on autism and Tourette syndrome. | Research review: the neurobiology and genetics of maltreatment and adversity. | Leiomyoma shrinkage after MRI-guided focused ultrasound treatment: report of 80 patients. | Investigations into the genetics of child psychiatric disorders have finally begun to shed light on molecular and cellular mechanisms of psychopathology. The first strains of success in this notoriously difficult area of inquiry are the result of an increasingly sophisticated appreciation of the allelic architecture of... | The neurobiological mechanisms by which childhood maltreatment heightens vulnerability to psychopathology remain poorly understood. It is likely that a complex interaction between environmental experiences (including poor caregiving) and an individual's genetic make-up influence neurobiological development across infan... | The purpose of this study was to assess the degree of leiomyoma ablation and shrinkage after MRI-guided focused ultrasound treatment performed according to U.S. Food and Drug Administration protocols for commercial trials.</AbstractText A total of 147 symptomatic leiomyomas in 80 women (average age, 46 years; range, 34... | The genetics of child psychiatric disorders: focus on autism and Tourette syndrome. Investigations into the genetics of child psychiatric disorders have finally begun to shed light on molecular and cellular mechanisms of psychopathology. The first strains of success in this notoriously difficult area of inquiry are the... | Research review: the neurobiology and genetics of maltreatment and adversity. The neurobiological mechanisms by which childhood maltreatment heightens vulnerability to psychopathology remain poorly understood. It is likely that a complex interaction between environmental experiences (including poor caregiving) and an i... | Leiomyoma shrinkage after MRI-guided focused ultrasound treatment: report of 80 patients. The purpose of this study was to assess the degree of leiomyoma ablation and shrinkage after MRI-guided focused ultrasound treatment performed according to U.S. Food and Drug Administration protocols for commercial trials.</Abstra... |
28862362 | 23584259 | 29889085 | Controlling the object phase for g-factor reduction in phase-Constrained parallel MRI using spatially selective RF pulses. | Sparsity-promoting calibration for GRAPPA accelerated parallel MRI reconstruction. | T-cell infiltration into the perilesional cortex is long-lasting and associates with poor somatomotor recovery after experimental traumatic brain injury. | Parallel imaging generally entails a reduction in the signal-to-noise ratio of the final image. Phase-constrained methods aim to improve reconstruction quality by using symmetry properties of k-space. Noise amplification in phase-constrained reconstruction depends heavily on the object background phase. The purpose of ... | The amount of calibration data needed to produce images of adequate quality can prevent auto-calibrating parallel imaging reconstruction methods like generalized autocalibrating partially parallel acquisitions (GRAPPA) from achieving a high total acceleration factor. To improve the quality of calibration when the numbe... | T-lymphocyte (T-cell) invasion into the brain parenchyma is a major consequence of traumatic brain injury (TBI). However, the role of T-cells in the post-TBI functional outcome and secondary inflammatory processes is unknown. We explored the dynamics of T-cell infiltration into the cortex after TBI to establish whether... | Controlling the object phase for g-factor reduction in phase-Constrained parallel MRI using spatially selective RF pulses. Parallel imaging generally entails a reduction in the signal-to-noise ratio of the final image. Phase-constrained methods aim to improve reconstruction quality by using symmetry properties of k-spa... | Sparsity-promoting calibration for GRAPPA accelerated parallel MRI reconstruction. The amount of calibration data needed to produce images of adequate quality can prevent auto-calibrating parallel imaging reconstruction methods like generalized autocalibrating partially parallel acquisitions (GRAPPA) from achieving a h... | T-cell infiltration into the perilesional cortex is long-lasting and associates with poor somatomotor recovery after experimental traumatic brain injury. T-lymphocyte (T-cell) invasion into the brain parenchyma is a major consequence of traumatic brain injury (TBI). However, the role of T-cells in the post-TBI function... |
32816570 | 25081016 | 36148712 | Uveal Effusion Associated with Presumed Viral Encephalitis. | Glutamate receptor antibodies in neurological diseases: anti-AMPA-GluR3 antibodies, anti-NMDA-NR1 antibodies, anti-NMDA-NR2A/B antibodies, anti-mGluR1 antibodies or anti-mGluR5 antibodies are present in subpopulations of patients with either: epilepsy, encephalitis, cerebellar ataxia, systemic lupus erythematosus (SLE)... | Non-essential heavy metals and protective effects of selenium against mercury toxicity in endangered Australian sea lion (Neophoca cinerea) pups with hookworm disease. | Uveal effusion is a rare disease that is characterized by exudative detachment of the ciliary body and choroid. Herein, we report a rare case of uveal effusion associated with viral encephalitis, which resolved following the treatment of the viral encephalitis and administration of corticosteroids.</AbstractText A 67-y... | Glutamate is the major excitatory neurotransmitter of the Central Nervous System (CNS), and it is crucially needed for numerous key neuronal functions. Yet, excess glutamate causes massive neuronal death and brain damage by excitotoxicity--detrimental over activation of glutamate receptors. Glutamate-mediated excitotox... | The endangered Australian sea lion, Neophoca cinerea, faces ongoing population decline. Identification of key threats to N. cinerea population recovery, including disease and pollutants, is an objective of the species' recovery plan. Previous studies have identified Uncinaria sanguinis, an intestinal nematode, as a sig... | Uveal Effusion Associated with Presumed Viral Encephalitis. Uveal effusion is a rare disease that is characterized by exudative detachment of the ciliary body and choroid. Herein, we report a rare case of uveal effusion associated with viral encephalitis, which resolved following the treatment of the viral encephalitis... | Glutamate receptor antibodies in neurological diseases: anti-AMPA-GluR3 antibodies, anti-NMDA-NR1 antibodies, anti-NMDA-NR2A/B antibodies, anti-mGluR1 antibodies or anti-mGluR5 antibodies are present in subpopulations of patients with either: epilepsy, encephalitis, cerebellar ataxia, systemic lupus erythematosus (SLE)... | Non-essential heavy metals and protective effects of selenium against mercury toxicity in endangered Australian sea lion (Neophoca cinerea) pups with hookworm disease. The endangered Australian sea lion, Neophoca cinerea, faces ongoing population decline. Identification of key threats to N. cinerea population recovery,... |
28149391 | 21073917 | 26960697 | Spatial control of reflexes, posture and movement in normal conditions and after neurological lesions. | Dynamic task-specific brain network connectivity in children with severe reading difficulties. | Women with premenstrual dysphoric disorder have altered sensitivity to allopregnanolone over the menstrual cycle compared to controls-a pilot study. | Control of reflexes is usually associated with central modulation of their sensitivity (gain) or phase-dependent inhibition and facilitation of their influences on motoneurons (reflex gating). Accumulated empirical findings show that the gain modulation and reflex gating are secondary, emergent properties of central co... | We investigated patterns of sensor-level functional connectivity derived from single-trial whole-head magnetoencephalography data during a pseudoword reading and a letter-sound naming task in children with reading difficulties (RD) and children with no reading impairments (NI). The Phase Lag Index (PLI), a linear and n... | In premenstrual dysphoric disorder (PMDD), a condition that afflicts 3-8 % of women in fertile ages, the cyclic recurrence of debilitating mood symptoms is restricted to the luteal phase of the menstrual cycle. The progesterone metabolite allopregnanolone is produced by the corpus luteum, and circulating levels ar... | Spatial control of reflexes, posture and movement in normal conditions and after neurological lesions. Control of reflexes is usually associated with central modulation of their sensitivity (gain) or phase-dependent inhibition and facilitation of their influences on motoneurons (reflex gating). Accumulated empirical fi... | Dynamic task-specific brain network connectivity in children with severe reading difficulties. We investigated patterns of sensor-level functional connectivity derived from single-trial whole-head magnetoencephalography data during a pseudoword reading and a letter-sound naming task in children with reading difficultie... | Women with premenstrual dysphoric disorder have altered sensitivity to allopregnanolone over the menstrual cycle compared to controls-a pilot study. In premenstrual dysphoric disorder (PMDD), a condition that afflicts 3-8 % of women in fertile ages, the cyclic recurrence of debilitating mood symptoms is restricted... |
39102762 | 35363534 | 39585059 | Manometric Abnormalities in Patients With and Without Chronic Cough. | Neuroimmune Interactions in Peripheral Organs. | The Role of Neuropeptide Y in the Pathogenesis of Alzheimer's Disease: Diagnostic Significance and Neuroprotective Functions. | This study examines the relationship between chronic cough and vagal hypersensitivity by measuring baseline esophageal motility, with interest in the upper esophageal sphincter (UES).</AbstractText Patients undergoing workup for dysphagia were assigned to a chronic cough or control group based on self-reported symptoms... | Interactions between the nervous and immune systems were recognized long ago, but recent studies show that this crosstalk occurs more frequently than was previously appreciated. Moreover, technological advances have enabled the identification of the molecular mediators and receptors that enable the interaction between ... | <b | Manometric Abnormalities in Patients With and Without Chronic Cough. This study examines the relationship between chronic cough and vagal hypersensitivity by measuring baseline esophageal motility, with interest in the upper esophageal sphincter (UES).</AbstractText Patients undergoing workup for dysphagia were assigne... | Neuroimmune Interactions in Peripheral Organs. Interactions between the nervous and immune systems were recognized long ago, but recent studies show that this crosstalk occurs more frequently than was previously appreciated. Moreover, technological advances have enabled the identification of the molecular mediators and... | The Role of Neuropeptide Y in the Pathogenesis of Alzheimer's Disease: Diagnostic Significance and Neuroprotective Functions. <b |
40480833 | 34271020 | 39724736 | Novel ADAR2 variants in children with seizures, intellectual disability and motor delay have reduced RNA editing. | Biology of AMPA receptor interacting proteins - From biogenesis to synaptic plasticity. | Mechanism of S100A9-mediated astrocyte activation via TLR4/NF-κB in Parkinson's disease. | The ADARB1 gene encodes the ADAR2 RNA editing enzyme, which edits the GRIA2 transcript Q/R editing site with almost 100% efficiency in the nervous system. The edited GRIA2R transcript encodes the GLUA2 R subunit isoform of tetrameric AMPA receptors, which is essential to prevent seizures associated with aberrantly elev... | AMPA-type glutamate receptors mediate the majority of excitatory synaptic transmission in the central nervous system. Their signaling properties and abundance at synapses are both crucial determinants of synapse efficacy and plasticity, and are therefore under sophisticated control. Unique to this ionotropic glutamate ... | Astrocyte-mediated neuroinflammation plays a key role in Parkinson's disease (PD) progression. The proinflammatory protein S100A9 is linked to various neurodegenerative diseases, but its involvement in astrocyte activation in PD remains unclear. Here, we investigate the role of S100A9 in astrocyte-mediated neuroinflamm... | Novel ADAR2 variants in children with seizures, intellectual disability and motor delay have reduced RNA editing. The ADARB1 gene encodes the ADAR2 RNA editing enzyme, which edits the GRIA2 transcript Q/R editing site with almost 100% efficiency in the nervous system. The edited GRIA2R transcript encodes the GLUA2 R su... | Biology of AMPA receptor interacting proteins - From biogenesis to synaptic plasticity. AMPA-type glutamate receptors mediate the majority of excitatory synaptic transmission in the central nervous system. Their signaling properties and abundance at synapses are both crucial determinants of synapse efficacy and plastic... | Mechanism of S100A9-mediated astrocyte activation via TLR4/NF-κB in Parkinson's disease. Astrocyte-mediated neuroinflammation plays a key role in Parkinson's disease (PD) progression. The proinflammatory protein S100A9 is linked to various neurodegenerative diseases, but its involvement in astrocyte activation in PD re... |
33033983 | 33223582 | 34098971 | Peak width of skeletonized mean diffusivity (PSMD) and cognitive functions in relapsing-remitting multiple sclerosis. | Transfer of Learning in People Who Are Blind: Enhancement of Spatial-Cognitive Abilities Through Drawing. | Policy options to increase motivation for improving evidence-informed health policy-making in Iran. | Peak width of skeletonized mean diffusivity (PSMD) is a new MRI marker, which has shown clinical relevance in some neurological conditions and, in preliminary data, in multiple sclerosis (MS). We aimed here to investigate, in a group of relapsing-remitting MS (RRMS) patients, the relationship between PSMD and cognitive... | This study assessed whether basic spatial-cognitive abilities can be enhanced in people who are blind through transfer of learning from drawing training.</AbstractText Near-body spatial-cognitive performance was assessed through the Cognitive Test for the Blind (CTB), which assesses a wide range of basic spatial-cognit... | Current incentive programmes are not sufficient to motivate researchers and policy-makers to use research evidence in policy-making. We conducted a mixed-methods design to identify context-based policy options for strengthening motivations among health researchers and policy-makers to support evidence-informed health p... | Peak width of skeletonized mean diffusivity (PSMD) and cognitive functions in relapsing-remitting multiple sclerosis. Peak width of skeletonized mean diffusivity (PSMD) is a new MRI marker, which has shown clinical relevance in some neurological conditions and, in preliminary data, in multiple sclerosis (MS). We aimed ... | Transfer of Learning in People Who Are Blind: Enhancement of Spatial-Cognitive Abilities Through Drawing. This study assessed whether basic spatial-cognitive abilities can be enhanced in people who are blind through transfer of learning from drawing training.</AbstractText Near-body spatial-cognitive performance was as... | Policy options to increase motivation for improving evidence-informed health policy-making in Iran. Current incentive programmes are not sufficient to motivate researchers and policy-makers to use research evidence in policy-making. We conducted a mixed-methods design to identify context-based policy options for streng... |
31288026 | 15930389 | 30455322 | Neural architecture of human language: Hierarchical structure building is independent from working memory. | Shifts of effective connectivity within a language network during rhyming and spelling. | Blood Pressure Goals in Patients with CKD: A Review of Evidence and Guidelines. | Using functional magnetic resonance imaging (fMRI), we show that the neural substrate of language does not overlap with that for verbal working memory when we carefully define verbal working memory in sentence processing. Object-Subject-Verb (OSV) sentences in Japanese were contrasted with canonical Subject-Object-Verb... | We used functional magnetic resonance imaging to examine task-specific modulations of effective connectivity within a left-hemisphere language network during spelling and rhyming judgments on visually presented words. We identified sites showing task-specific activations for rhyming in the lateral temporal cortex (LTC)... | Hypertension affects the vast majority of patients with CKD and increases the risk of cardiovascular disease, ESKD, and death. Over the past decade, a number of hypertension guidelines have been published with varying recommendations for BP goals in patients with CKD. Most recently, the American College of Cardiology/A... | Neural architecture of human language: Hierarchical structure building is independent from working memory. Using functional magnetic resonance imaging (fMRI), we show that the neural substrate of language does not overlap with that for verbal working memory when we carefully define verbal working memory in sentence pro... | Shifts of effective connectivity within a language network during rhyming and spelling. We used functional magnetic resonance imaging to examine task-specific modulations of effective connectivity within a left-hemisphere language network during spelling and rhyming judgments on visually presented words. We identified ... | Blood Pressure Goals in Patients with CKD: A Review of Evidence and Guidelines. Hypertension affects the vast majority of patients with CKD and increases the risk of cardiovascular disease, ESKD, and death. Over the past decade, a number of hypertension guidelines have been published with varying recommendations for BP... |
38360144 | 27251213 | 39023368 | Continuous electrical stimulation of superior laryngeal nerve inhibits initiation of swallowing in anesthetized rats. | Vagal neurocircuitry and its influence on gastric motility. | Speaker Demographics Modulate Listeners' Neural Correlates of Spoken Word Processing. | Pharyngeal electrical stimulation (PES) applies electrical stimulation to pharyngeal mucosa (PhM) and represents a useful approach to improve swallowing function in patients with dysphagia. To determine the optimal PES modality to treat dysphagia, the mechanism underlying the effects of PES on swallowing function must ... | A large body of research has been dedicated to the effects of gastrointestinal peptides on vagal afferent fibres, yet multiple lines of evidence indicate that gastrointestinal peptides also modulate brainstem vagal neurocircuitry, and that this modulation has a fundamental role in the physiology and pathophysiology of ... | In language comprehension, listeners expect a speaker to be consistent in their word choice for labeling the same object. For instance, if a speaker previously refers to a piece of furniture as a "couch," in subsequent references, listeners would expect the speaker to repeat this label instead of switching to an altern... | Continuous electrical stimulation of superior laryngeal nerve inhibits initiation of swallowing in anesthetized rats. Pharyngeal electrical stimulation (PES) applies electrical stimulation to pharyngeal mucosa (PhM) and represents a useful approach to improve swallowing function in patients with dysphagia. To determine... | Vagal neurocircuitry and its influence on gastric motility. A large body of research has been dedicated to the effects of gastrointestinal peptides on vagal afferent fibres, yet multiple lines of evidence indicate that gastrointestinal peptides also modulate brainstem vagal neurocircuitry, and that this modulation has ... | Speaker Demographics Modulate Listeners' Neural Correlates of Spoken Word Processing. In language comprehension, listeners expect a speaker to be consistent in their word choice for labeling the same object. For instance, if a speaker previously refers to a piece of furniture as a "couch," in subsequent references, lis... |
36796237 | 32900658 | 37779723 | A comparison of how deep brain stimulation in two targets with anti-compulsive efficacy modulates brain activity using fMRI in awake rats. | Temporal Dynamics of Large-Scale Networks Predict Neural Cue Reactivity and Cue-Induced Craving. | Molecular surveillance of dengue virus in field-collected Aedes mosquitoes from Bhopal, central India: evidence of circulation of a new lineage of serotype 2. | Deep brain stimulation (DBS) is an established neuromodulatory intervention against otherwise treatment-refractory obsessive-compulsive disorder (OCD). Several DBS targets, all of which are part of brain networks connecting basal ganglia and prefrontal cortex, alleviate OCD symptoms. Stimulation of these targets is tho... | Cue reactivity, a core characteristic of substance use disorders, commonly recruits brain regions that are key nodes in neurocognitive networks, including the default mode network (DMN) and salience network (SN). Whether resting-state temporal dynamic properties of these networks relate to subsequent cue reactivity and... | Dengue fever is hyperendemic in several Southeast and South Asian countries, including India, with all four serotypes (DENV 1-4) circulating at different periods and in different locations. Sustainable and improved virological and entomological surveillance is the only tool to prevent dengue and other vector-borne dise... | A comparison of how deep brain stimulation in two targets with anti-compulsive efficacy modulates brain activity using fMRI in awake rats. Deep brain stimulation (DBS) is an established neuromodulatory intervention against otherwise treatment-refractory obsessive-compulsive disorder (OCD). Several DBS targets, all of w... | Temporal Dynamics of Large-Scale Networks Predict Neural Cue Reactivity and Cue-Induced Craving. Cue reactivity, a core characteristic of substance use disorders, commonly recruits brain regions that are key nodes in neurocognitive networks, including the default mode network (DMN) and salience network (SN). Whether re... | Molecular surveillance of dengue virus in field-collected Aedes mosquitoes from Bhopal, central India: evidence of circulation of a new lineage of serotype 2. Dengue fever is hyperendemic in several Southeast and South Asian countries, including India, with all four serotypes (DENV 1-4) circulating at different periods... |
35047400 | 24214526 | 34393924 | Amide Proton Transfer Weighted and Intravoxel Incoherent Motion Imaging in Evaluation of Prognostic Factors for Rectal Adenocarcinoma. | Quantification of amide proton transfer effect pre- and post-gadolinium contrast agent administration. | Neuroscience, Empathy, and Violent Crime in an Incarcerated Population: A Narrative Review. | To analyze the value of amide proton transfer (APT) weighted and intravoxel incoherent motion (IVIM) imaging in evaluation of prognostic factors for rectal adenocarcinoma, compared with diffusion weighted imaging (DWI).</AbstractText Preoperative pelvic MRI data of 110 patients with surgical pathologically confirmed di... | To compare quantification of the amide proton transfer (APT) effect pre- and post-gadolinium contrast agent (Gd) administration in order to establish to what extent Gd alters quantification of the APT effect.</AbstractText Four patients with internal carotid stenosis were recruited. APT imaging was acquired pre- and po... | Empathy is a fundamental construct that allows individuals to perceive and understand the cognitive and emotional state of others. Empathy is not only a psychological and sociological concept; it also heavily impacts our daily lives by affecting our decisions and actions. Empathy is connected to and involves specific p... | Amide Proton Transfer Weighted and Intravoxel Incoherent Motion Imaging in Evaluation of Prognostic Factors for Rectal Adenocarcinoma. To analyze the value of amide proton transfer (APT) weighted and intravoxel incoherent motion (IVIM) imaging in evaluation of prognostic factors for rectal adenocarcinoma, compared with... | Quantification of amide proton transfer effect pre- and post-gadolinium contrast agent administration. To compare quantification of the amide proton transfer (APT) effect pre- and post-gadolinium contrast agent (Gd) administration in order to establish to what extent Gd alters quantification of the APT effect.</Abstrac... | Neuroscience, Empathy, and Violent Crime in an Incarcerated Population: A Narrative Review. Empathy is a fundamental construct that allows individuals to perceive and understand the cognitive and emotional state of others. Empathy is not only a psychological and sociological concept; it also heavily impacts our daily l... |
37851553 | 35070225 | 38214229 | Deep Representation Learning With Sample Generation and Augmented Attention Module for Imbalanced ECG Classification. | A Novel Diabetes Healthcare Disease Prediction Framework Using Machine Learning Techniques. | A super minigene with a short promoter and truncated introns recapitulates essential features of transcription and splicing regulation of the SMN1 and SMN2 genes. | Developing an efficient heartbeat monitoring system has become a focal point in numerous healthcare applications. Specifically, in the last few years, heartbeat classification for arrhythmia detection has gained considerable interest from researchers. This paper presents a novel deep representation learning method for ... | Diabetes is a chronic disease that continues to be a significant and global concern since it affects the entire population's health. It is a metabolic disorder that leads to high blood sugar levels and many other problems such as stroke, kidney failure, and heart and nerve problems. Several researchers have attempted t... | Here we report a Survival Motor Neuron 2 (SMN2) super minigene, SMN2Sup, encompassing its own promoter, all exons, their flanking intronic sequences and the entire 3'-untranslated region. We confirm that the pre-mRNA generated from SMN2Sup undergoes splicing to produce a translation-competent mRNA. We demonstrate that ... | Deep Representation Learning With Sample Generation and Augmented Attention Module for Imbalanced ECG Classification. Developing an efficient heartbeat monitoring system has become a focal point in numerous healthcare applications. Specifically, in the last few years, heartbeat classification for arrhythmia detection h... | A Novel Diabetes Healthcare Disease Prediction Framework Using Machine Learning Techniques. Diabetes is a chronic disease that continues to be a significant and global concern since it affects the entire population's health. It is a metabolic disorder that leads to high blood sugar levels and many other problems such a... | A super minigene with a short promoter and truncated introns recapitulates essential features of transcription and splicing regulation of the SMN1 and SMN2 genes. Here we report a Survival Motor Neuron 2 (SMN2) super minigene, SMN2Sup, encompassing its own promoter, all exons, their flanking intronic sequences and the ... |
18404869 | 27374335 | 19049709 | Optimal control of psychological processes: a new computational paradigm. | Learning to Associate Orientation with Color in Early Visual Areas by Associative Decoded fMRI Neurofeedback. | Nephrogenic systemic fibrosis: the first Italian gadolinium-proven case. | In this paper, we use general mathematical-statistical theorems to prove that developmental processes must be studied at the intra-individual level. We demonstrate how to model intra-individual variation using single-participant time series analysis with time-varying parameters. We use advanced signal analysis techniqu... | Associative learning is an essential brain process where the contingency of different items increases after training. Associative learning has been found to occur in many brain regions [1-4]. However, there is no clear evidence that associative learning of visual features occurs in early visual areas, although a number... | Nephrogenic systemic fibrosis (NSF) is a systemic disease, recently described in patients with advanced chronic kidney disease (CKD), characterized by progressive scleromyxedema-like fibrotic involvement mainly of the skin. We describe the case of a 66-year-old woman on chronic hemodialysis for end-stage renal failure,... | Optimal control of psychological processes: a new computational paradigm. In this paper, we use general mathematical-statistical theorems to prove that developmental processes must be studied at the intra-individual level. We demonstrate how to model intra-individual variation using single-participant time series analy... | Learning to Associate Orientation with Color in Early Visual Areas by Associative Decoded fMRI Neurofeedback. Associative learning is an essential brain process where the contingency of different items increases after training. Associative learning has been found to occur in many brain regions [1-4]. However, there is ... | Nephrogenic systemic fibrosis: the first Italian gadolinium-proven case. Nephrogenic systemic fibrosis (NSF) is a systemic disease, recently described in patients with advanced chronic kidney disease (CKD), characterized by progressive scleromyxedema-like fibrotic involvement mainly of the skin. We describe the case of... |
26769224 | 21199535 | 27145112 | Involvement of GABAB Receptor Signaling in Antipsychotic-like Action of the Novel Orthosteric Agonist of the mGlu4 Receptor, LSP4-2022. | The analgesic effects of the GABAB receptor agonist, baclofen, in a rodent model of functional dyspepsia. | Multielectrode Array (MEA) Assay for Profiling Electrophysiological Drug Effects in Human Stem Cell-Derived Cardiomyocytes. | Considering that ligands of metabotropic glutamate and GABA receptors may exert beneficial effects on schizophrenia, we assessed the actions of the first mGlu>4-selective orthosteric agonist, LSP4-2022, in several tests reflecting positive, negative, and cognitive symptoms of schizophrenia. Moreover, we investigated... | The amino acid γ-aminobutyric acid (GABA) is an important modulator of pain but its role in visceral pain syndromes is just beginning to be studied. Our aims were to investigate the effect and mechanism of action of the GABA(B) receptor agonist, baclofen, on gastric hypersensitivity in a validated rat model of fu... | More relevant and reliable preclinical cardiotoxicity tests are required to improve drug safety and reduce the cost of drug development. Human stem cell-derived cardiomyocytes (hSC-CMs) provide a potential model for the development of superior assays for preclinical drug safety screening. One such hSC-CM assay that has... | Involvement of GABAB Receptor Signaling in Antipsychotic-like Action of the Novel Orthosteric Agonist of the mGlu4 Receptor, LSP4-2022. Considering that ligands of metabotropic glutamate and GABA receptors may exert beneficial effects on schizophrenia, we assessed the actions of the first mGlu>4-selective orthosteri... | The analgesic effects of the GABAB receptor agonist, baclofen, in a rodent model of functional dyspepsia. The amino acid γ-aminobutyric acid (GABA) is an important modulator of pain but its role in visceral pain syndromes is just beginning to be studied. Our aims were to investigate the effect and mechanism of ac... | Multielectrode Array (MEA) Assay for Profiling Electrophysiological Drug Effects in Human Stem Cell-Derived Cardiomyocytes. More relevant and reliable preclinical cardiotoxicity tests are required to improve drug safety and reduce the cost of drug development. Human stem cell-derived cardiomyocytes (hSC-CMs) provide a ... |
31617444 | 25310420 | 31941660 | Focused ultrasound thalamotomy for multiple sclerosis-associated tremor. | Cardiovascular MR imaging at 3 T: opportunities, challenges, and solutions. | Optogenetic Activation of β-Endorphin Terminals in the Medial Preoptic Nucleus Regulates Female Sexual Receptivity. | Multiple sclerosis (MS)-related tremor is frequent and can often be refractory to medical treatment, which makes it a potential source of major disability. Functional neurosurgery approaches such as thalamic deep brain stimulation (DBS) or radiofrequency thalamotomy are proven to be effective, but the application of in... | Although 3-T magnetic resonance (MR) imaging is well established in neuroradiology and musculoskeletal imaging, it is in the nascent stages in cardiovascular imaging applications, and there is limited literature on this topic. The primary advantage of 3 T over 1.5 T is a higher signal-to-noise ratio (SNR), which can be... | Estrogen and progesterone (P4) act in neural circuits to elicit lordosis, the stereotypical female sexual receptivity behavior. Estradiol acts through membrane receptors to rapidly activate a limbic-hypothalamic circuit consisting of the arcuate (ARH), medial preoptic (MPN), and ventromedial (VMH) nuclei of the hypotha... | Focused ultrasound thalamotomy for multiple sclerosis-associated tremor. Multiple sclerosis (MS)-related tremor is frequent and can often be refractory to medical treatment, which makes it a potential source of major disability. Functional neurosurgery approaches such as thalamic deep brain stimulation (DBS) or radiofr... | Cardiovascular MR imaging at 3 T: opportunities, challenges, and solutions. Although 3-T magnetic resonance (MR) imaging is well established in neuroradiology and musculoskeletal imaging, it is in the nascent stages in cardiovascular imaging applications, and there is limited literature on this topic. The primary advan... | Optogenetic Activation of β-Endorphin Terminals in the Medial Preoptic Nucleus Regulates Female Sexual Receptivity. Estrogen and progesterone (P4) act in neural circuits to elicit lordosis, the stereotypical female sexual receptivity behavior. Estradiol acts through membrane receptors to rapidly activate a limbic-hypot... |
40751218 | 26404723 | 40710493 | Monosodium glutamate exacerbated the lipopolysaccharide-induced reproductive toxicity of male Wistar rats. | (31)P-MRS of healthy human brain: ATP synthesis, metabolite concentrations, pH, and T1 relaxation times. | Selective Antiproliferative Effects of Marine Oils on Neuroblastoma Cells in 3D Cultures. | Monosodium glutamate (MSG) is a common food additive that has been linked to oxidative stress and reproductive dysfunction. Lipopolysaccharide (LPS), a bacterial endotoxin, is known to induce systemic inflammation, leading to oxidative damage and hormonal disruption. This study investigated whether MSG exacerbates LPS-... | The conventional method for measuring brain ATP synthesis is (31)P saturation transfer (ST), a technique typically dependent on prolonged pre-saturation with γ-ATP. In this study, ATP synthesis rate in resting human brain is evaluated using EBIT (exchange kinetics by band inversion transfer), a technique based on... | Dietary marine lipids enriched in <i | Monosodium glutamate exacerbated the lipopolysaccharide-induced reproductive toxicity of male Wistar rats. Monosodium glutamate (MSG) is a common food additive that has been linked to oxidative stress and reproductive dysfunction. Lipopolysaccharide (LPS), a bacterial endotoxin, is known to induce systemic inflammation... | (31)P-MRS of healthy human brain: ATP synthesis, metabolite concentrations, pH, and T1 relaxation times. The conventional method for measuring brain ATP synthesis is (31)P saturation transfer (ST), a technique typically dependent on prolonged pre-saturation with γ-ATP. In this study, ATP synthesis rate in resting... | Selective Antiproliferative Effects of Marine Oils on Neuroblastoma Cells in 3D Cultures. Dietary marine lipids enriched in <i |
30239439 | 28168521 | 30150657 | Microstructural Alterations in the Brains of Adults With Prelingual Sensorineural Hearing Loss: a Diffusion Kurtosis Imaging Study. | Does apolipoprotein A1 predict microstructural changes in subgenual cingulum in early Parkinson? | Deciding for others as a neutral party recruits risk-neutral perspective-taking: Model-based behavioral and fMRI experiments. | To investigate the alterations in microstructural gray matter (GM) and white matter (WM) in adults with prelingual sensorineural hearing loss (SNHL) using diffusion kurtosis imaging (DKI) and explore whether the clinical data are associated with the whole brain structure changes in SNHL subjects.</AbstractText Prospect... | Higher plasma cholesterol levels are associated with lower Parkinson's disease (PD) risk. Apolipoprotein A-1 (ApoA-1) is a surface marker of brain HDL-like particles associated with the time of PD onset. Clinical correlates of serum Apolipoprotein A1 levels with structural brain connectivity in PD-related disorders
... | Risky decision making for others is ubiquitous in our societies. Whereas financial decision making for oneself induces strong concern about the worst outcome (maximin concern) as well as the expected value, behavioral and neural characteristics of decision making for others are less well understood. We conducted behavi... | Microstructural Alterations in the Brains of Adults With Prelingual Sensorineural Hearing Loss: a Diffusion Kurtosis Imaging Study. To investigate the alterations in microstructural gray matter (GM) and white matter (WM) in adults with prelingual sensorineural hearing loss (SNHL) using diffusion kurtosis imaging (DKI) ... | Does apolipoprotein A1 predict microstructural changes in subgenual cingulum in early Parkinson? Higher plasma cholesterol levels are associated with lower Parkinson's disease (PD) risk. Apolipoprotein A-1 (ApoA-1) is a surface marker of brain HDL-like particles associated with the time of PD onset. Clinical correlates... | Deciding for others as a neutral party recruits risk-neutral perspective-taking: Model-based behavioral and fMRI experiments. Risky decision making for others is ubiquitous in our societies. Whereas financial decision making for oneself induces strong concern about the worst outcome (maximin concern) as well as the exp... |
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